UBTF

 

Full name: upstream binding transcription factor Alias Symbol: UBF|NOR-90|UBF1|UBF2
Type: protein-coding gene Cytoband: 17q21.31
Entrez ID: 7343 HGNC ID: HGNC:12511 Ensembl Gene: ENSG00000108312 OMIM ID: 600673
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of UBTF:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 UBTF 7343 225982_at 0.1992 0.6832
GSE20347 UBTF 7343 202692_s_at 0.2707 0.0072
GSE23400 UBTF 7343 202692_s_at 0.1510 0.0010
GSE26886 UBTF 7343 225982_at -0.0745 0.6927
GSE29001 UBTF 7343 202692_s_at 0.1534 0.5911
GSE38129 UBTF 7343 202692_s_at 0.1039 0.3056
GSE45670 UBTF 7343 225982_at -0.0231 0.8662
GSE53622 UBTF 7343 19531 -0.1349 0.1940
GSE53624 UBTF 7343 19531 -0.1321 0.0584
GSE63941 UBTF 7343 225982_at 0.4176 0.1882
GSE77861 UBTF 7343 225982_at 0.0853 0.5958
GSE97050 UBTF 7343 A_24_P349616 0.2649 0.2636
SRP007169 UBTF 7343 RNAseq 0.9768 0.0256
SRP008496 UBTF 7343 RNAseq 0.9318 0.0024
SRP064894 UBTF 7343 RNAseq 0.2852 0.0396
SRP133303 UBTF 7343 RNAseq 0.0435 0.7233
SRP159526 UBTF 7343 RNAseq 0.2353 0.2565
SRP193095 UBTF 7343 RNAseq 0.1079 0.1339
SRP219564 UBTF 7343 RNAseq -0.0817 0.7475
TCGA UBTF 7343 RNAseq 0.0667 0.1232

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by UBTF expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of UBTF:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 UBTF 7343 5 2 23
GSE20123 UBTF 7343 5 2 23
GSE43470 UBTF 7343 1 2 40
GSE46452 UBTF 7343 32 0 27
GSE47630 UBTF 7343 9 0 31
GSE54993 UBTF 7343 3 4 63
GSE54994 UBTF 7343 8 5 40
GSE60625 UBTF 7343 4 0 7
GSE74703 UBTF 7343 1 1 34
GSE74704 UBTF 7343 3 1 16
TCGA UBTF 7343 23 7 66

Total number of gains: 94; Total number of losses: 24; Total Number of normals: 370.  

 

Somatic mutations of UBTF:

 

Generating mutation plots.

 

Highly correlated genes for UBTF:

 

Showing top 20/106 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
UBTFPTRH10.757262303
UBTFCTSD0.701762303
UBTFHMGXB30.697012303
UBTFZNF1800.635685303
UBTFBRD10.625779404
UBTFTIMELESS0.624342303
UBTFKDF10.618167403
UBTFMTG10.611377403
UBTFSAFB0.610962605
UBTFRPS290.610852403
UBTFSTK250.609587403
UBTFSTK110.603311503
UBTFCDC70.602569404
UBTFZWINT0.597993403
UBTFSTEAP30.597605303
UBTFTLE30.596571605
UBTFSLC45A30.594434403
UBTFLSM70.593206403
UBTFSURF20.590537403
UBTFINTS50.590208503

For details and further investigation, click here