| Full name: caspase 12 (gene/pseudogene) | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 100506742 | HGNC ID: HGNC:19004 | Ensembl Gene: ENSG00000204403 | OMIM ID: 608633 |
| Drug and gene relationship at DGIdb | |||
CASP12 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa05161 | Hepatitis B |
Expression of CASP12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASP12 | 100506742 | 1564736_a_at | -0.2102 | 0.4047 | |
| GSE26886 | CASP12 | 100506742 | 1564736_a_at | 0.0128 | 0.9070 | |
| GSE45670 | CASP12 | 100506742 | 1564736_a_at | -0.1109 | 0.2489 | |
| GSE53622 | CASP12 | 100506742 | 12996 | -0.2061 | 0.0035 | |
| GSE53624 | CASP12 | 100506742 | 13006 | -0.7377 | 0.0000 | |
| GSE63941 | CASP12 | 100506742 | 1564736_a_at | -0.2593 | 0.1235 | |
| GSE77861 | CASP12 | 100506742 | 1564736_a_at | -0.1206 | 0.1198 | |
| GSE97050 | CASP12 | 100506742 | A_23_P13102 | -0.2573 | 0.3976 | |
| TCGA | CASP12 | 100506742 | RNAseq | -1.9762 | 0.0023 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CASP12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASP12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASP12 | 100506742 | 1 | 11 | 18 | |
| GSE20123 | CASP12 | 100506742 | 1 | 11 | 18 | |
| GSE43470 | CASP12 | 100506742 | 3 | 6 | 34 | |
| GSE46452 | CASP12 | 100506742 | 3 | 26 | 30 | |
| GSE47630 | CASP12 | 100506742 | 2 | 19 | 19 | |
| GSE54993 | CASP12 | 100506742 | 9 | 1 | 60 | |
| GSE54994 | CASP12 | 100506742 | 4 | 19 | 30 | |
| GSE60625 | CASP12 | 100506742 | 0 | 3 | 8 | |
| GSE74703 | CASP12 | 100506742 | 2 | 4 | 30 | |
| GSE74704 | CASP12 | 100506742 | 1 | 7 | 12 | |
| TCGA | CASP12 | 100506742 | 9 | 44 | 43 |
Total number of gains: 35; Total number of losses: 151; Total Number of normals: 302.
Somatic mutations of CASP12:
Generating mutation plots.
Highly correlated genes for CASP12:
Showing top 20/61 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASP12 | CNGA4 | 0.720098 | 3 | 0 | 3 |
| CASP12 | ZNF630 | 0.681427 | 4 | 0 | 3 |
| CASP12 | PLCD4 | 0.676446 | 4 | 0 | 3 |
| CASP12 | ATP6AP1L | 0.676361 | 3 | 0 | 3 |
| CASP12 | GPR88 | 0.661235 | 3 | 0 | 3 |
| CASP12 | IGSF9B | 0.655777 | 3 | 0 | 3 |
| CASP12 | CYP2E1 | 0.641685 | 3 | 0 | 3 |
| CASP12 | KRT32 | 0.64065 | 4 | 0 | 3 |
| CASP12 | HTR3A | 0.63735 | 3 | 0 | 3 |
| CASP12 | SLC17A4 | 0.624059 | 3 | 0 | 3 |
| CASP12 | THPO | 0.619113 | 5 | 0 | 3 |
| CASP12 | DCX | 0.617139 | 4 | 0 | 3 |
| CASP12 | SNX24 | 0.606944 | 3 | 0 | 3 |
| CASP12 | RDM1 | 0.600276 | 3 | 0 | 3 |
| CASP12 | WDR87 | 0.597997 | 4 | 0 | 3 |
| CASP12 | TAS2R3 | 0.597557 | 4 | 0 | 3 |
| CASP12 | SLITRK1 | 0.595015 | 3 | 0 | 3 |
| CASP12 | CNGA3 | 0.592315 | 4 | 0 | 3 |
| CASP12 | FOXP1 | 0.58983 | 5 | 0 | 3 |
| CASP12 | ZNF843 | 0.588699 | 3 | 0 | 3 |
For details and further investigation, click here
