| Full name: cyclic nucleotide gated channel subunit alpha 3 | Alias Symbol: CCNC1|CCNCa|CNG3 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 1261 | HGNC ID: HGNC:2150 | Ensembl Gene: ENSG00000144191 | OMIM ID: 600053 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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CNGA3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04740 | Olfactory transduction |
Expression of CNGA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNGA3 | 1261 | 207261_at | -0.6389 | 0.3838 | |
| GSE20347 | CNGA3 | 1261 | 207261_at | 0.0119 | 0.8950 | |
| GSE23400 | CNGA3 | 1261 | 207261_at | -0.1881 | 0.0004 | |
| GSE26886 | CNGA3 | 1261 | 207261_at | -0.0379 | 0.6658 | |
| GSE29001 | CNGA3 | 1261 | 207261_at | -0.1149 | 0.4699 | |
| GSE38129 | CNGA3 | 1261 | 207261_at | -0.2974 | 0.0215 | |
| GSE45670 | CNGA3 | 1261 | 207261_at | -1.0011 | 0.0002 | |
| GSE53622 | CNGA3 | 1261 | 8628 | -0.5290 | 0.0001 | |
| GSE53624 | CNGA3 | 1261 | 8628 | -0.2824 | 0.0000 | |
| GSE63941 | CNGA3 | 1261 | 207261_at | -0.8763 | 0.0016 | |
| GSE77861 | CNGA3 | 1261 | 207261_at | -0.0920 | 0.2928 | |
| GSE97050 | CNGA3 | 1261 | A_33_P3291939 | -0.4950 | 0.3997 | |
| TCGA | CNGA3 | 1261 | RNAseq | -2.2216 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CNGA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNGA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNGA3 | 1261 | 6 | 2 | 22 | |
| GSE20123 | CNGA3 | 1261 | 6 | 2 | 22 | |
| GSE43470 | CNGA3 | 1261 | 3 | 2 | 38 | |
| GSE46452 | CNGA3 | 1261 | 2 | 3 | 54 | |
| GSE47630 | CNGA3 | 1261 | 7 | 0 | 33 | |
| GSE54993 | CNGA3 | 1261 | 0 | 6 | 64 | |
| GSE54994 | CNGA3 | 1261 | 10 | 0 | 43 | |
| GSE60625 | CNGA3 | 1261 | 0 | 3 | 8 | |
| GSE74703 | CNGA3 | 1261 | 3 | 2 | 31 | |
| GSE74704 | CNGA3 | 1261 | 4 | 1 | 15 | |
| TCGA | CNGA3 | 1261 | 34 | 4 | 58 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of CNGA3:
Generating mutation plots.
Highly correlated genes for CNGA3:
Showing top 20/737 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNGA3 | GALNT15 | 0.77901 | 3 | 0 | 3 |
| CNGA3 | KLHL41 | 0.748451 | 3 | 0 | 3 |
| CNGA3 | DACT3 | 0.743107 | 6 | 0 | 6 |
| CNGA3 | ABCA9 | 0.742335 | 3 | 0 | 3 |
| CNGA3 | LINC00702 | 0.738871 | 3 | 0 | 3 |
| CNGA3 | STK33 | 0.733005 | 4 | 0 | 3 |
| CNGA3 | LINC00968 | 0.730987 | 3 | 0 | 3 |
| CNGA3 | MGARP | 0.726722 | 3 | 0 | 3 |
| CNGA3 | RSPO1 | 0.721301 | 3 | 0 | 3 |
| CNGA3 | RASL12 | 0.721254 | 7 | 0 | 7 |
| CNGA3 | TAF1 | 0.718091 | 3 | 0 | 3 |
| CNGA3 | GKAP1 | 0.714681 | 3 | 0 | 3 |
| CNGA3 | PLA2G5 | 0.714004 | 8 | 0 | 8 |
| CNGA3 | MYL1 | 0.712819 | 3 | 0 | 3 |
| CNGA3 | SCARA5 | 0.70666 | 3 | 0 | 3 |
| CNGA3 | SMIM10 | 0.70477 | 4 | 0 | 4 |
| CNGA3 | SEMA3A | 0.702788 | 5 | 0 | 5 |
| CNGA3 | SPATA4 | 0.695048 | 3 | 0 | 3 |
| CNGA3 | MOB2 | 0.692491 | 3 | 0 | 3 |
| CNGA3 | IL17D | 0.690651 | 4 | 0 | 4 |
For details and further investigation, click here
