THPO

 

Full name: thrombopoietin Alias Symbol: TPO|MPLLG
Type: protein-coding gene Cytoband: 3q27.1
Entrez ID: 7066 HGNC ID: HGNC:11795 Ensembl Gene: ENSG00000090534 OMIM ID: 600044
Drug and gene relationship at DGIdb

 

THPO involved pathways:

KEGG pathway Description View
hsa04630Jak-STAT signaling pathway

 

Expression of THPO:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 THPO 7066 211831_s_at -0.1841 0.4640
GSE20347 THPO 7066 211831_s_at -0.1522 0.0233
GSE23400 THPO 7066 211831_s_at -0.2532 0.0000
GSE26886 THPO 7066 211831_s_at -0.1953 0.1389
GSE29001 THPO 7066 211831_s_at -0.3172 0.0106
GSE38129 THPO 7066 211831_s_at -0.1865 0.0041
GSE45670 THPO 7066 211831_s_at 0.0365 0.7044
GSE53622 THPO 7066 60745 -0.2635 0.0266
GSE53624 THPO 7066 60666 -1.1158 0.0000
GSE63941 THPO 7066 211831_s_at 0.2482 0.1415
GSE77861 THPO 7066 211831_s_at -0.2463 0.0542
GSE97050 THPO 7066 A_24_P377124 -0.0918 0.7546
SRP159526 THPO 7066 RNAseq 1.2602 0.0345
SRP219564 THPO 7066 RNAseq 0.1020 0.8704
TCGA THPO 7066 RNAseq -0.5555 0.1944

Upregulated datasets: 1; Downregulated datasets: 1.  


 

Survival by THPO expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of THPO:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 THPO 7066 25 0 5
GSE20123 THPO 7066 25 0 5
GSE43470 THPO 7066 25 0 18
GSE46452 THPO 7066 19 1 39
GSE47630 THPO 7066 27 2 11
GSE54993 THPO 7066 1 19 50
GSE54994 THPO 7066 41 0 12
GSE60625 THPO 7066 0 6 5
GSE74703 THPO 7066 21 0 15
GSE74704 THPO 7066 17 0 3
TCGA THPO 7066 77 0 19

Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.  


 

Somatic mutations of THPO:

 

Generating mutation plots.

 

Highly correlated genes for THPO:

 

Showing top 20/807 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
THPOATP6AP1L0.778487303
THPOKCNA60.770419303
THPOHMGCLL10.765258303
THPONCR30.761773303
THPOSP70.752714303
THPOBARHL20.739313303
THPOAICDA0.73782303
THPOHMGB40.734677303
THPOCCDC1570.73195404
THPOCALML60.73176303
THPOZNF810.71309303
THPOL3MBTL10.702504303
THPOCLEC18C0.700218303
THPOTNP10.698415504
THPOLIME10.696749303
THPOSRD5A20.693245403
THPOSLC1A70.689537605
THPOSTXBP60.689123303
THPOABCC60.687456303
THPOKATNAL20.686119303

For details and further investigation, click here