| Full name: thrombopoietin | Alias Symbol: TPO|MPLLG | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 7066 | HGNC ID: HGNC:11795 | Ensembl Gene: ENSG00000090534 | OMIM ID: 600044 |
| Drug and gene relationship at DGIdb | |||
THPO involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of THPO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THPO | 7066 | 211831_s_at | -0.1841 | 0.4640 | |
| GSE20347 | THPO | 7066 | 211831_s_at | -0.1522 | 0.0233 | |
| GSE23400 | THPO | 7066 | 211831_s_at | -0.2532 | 0.0000 | |
| GSE26886 | THPO | 7066 | 211831_s_at | -0.1953 | 0.1389 | |
| GSE29001 | THPO | 7066 | 211831_s_at | -0.3172 | 0.0106 | |
| GSE38129 | THPO | 7066 | 211831_s_at | -0.1865 | 0.0041 | |
| GSE45670 | THPO | 7066 | 211831_s_at | 0.0365 | 0.7044 | |
| GSE53622 | THPO | 7066 | 60745 | -0.2635 | 0.0266 | |
| GSE53624 | THPO | 7066 | 60666 | -1.1158 | 0.0000 | |
| GSE63941 | THPO | 7066 | 211831_s_at | 0.2482 | 0.1415 | |
| GSE77861 | THPO | 7066 | 211831_s_at | -0.2463 | 0.0542 | |
| GSE97050 | THPO | 7066 | A_24_P377124 | -0.0918 | 0.7546 | |
| SRP159526 | THPO | 7066 | RNAseq | 1.2602 | 0.0345 | |
| SRP219564 | THPO | 7066 | RNAseq | 0.1020 | 0.8704 | |
| TCGA | THPO | 7066 | RNAseq | -0.5555 | 0.1944 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by THPO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THPO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THPO | 7066 | 25 | 0 | 5 | |
| GSE20123 | THPO | 7066 | 25 | 0 | 5 | |
| GSE43470 | THPO | 7066 | 25 | 0 | 18 | |
| GSE46452 | THPO | 7066 | 19 | 1 | 39 | |
| GSE47630 | THPO | 7066 | 27 | 2 | 11 | |
| GSE54993 | THPO | 7066 | 1 | 19 | 50 | |
| GSE54994 | THPO | 7066 | 41 | 0 | 12 | |
| GSE60625 | THPO | 7066 | 0 | 6 | 5 | |
| GSE74703 | THPO | 7066 | 21 | 0 | 15 | |
| GSE74704 | THPO | 7066 | 17 | 0 | 3 | |
| TCGA | THPO | 7066 | 77 | 0 | 19 |
Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.
Somatic mutations of THPO:
Generating mutation plots.
Highly correlated genes for THPO:
Showing top 20/807 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THPO | ATP6AP1L | 0.778487 | 3 | 0 | 3 |
| THPO | KCNA6 | 0.770419 | 3 | 0 | 3 |
| THPO | HMGCLL1 | 0.765258 | 3 | 0 | 3 |
| THPO | NCR3 | 0.761773 | 3 | 0 | 3 |
| THPO | SP7 | 0.752714 | 3 | 0 | 3 |
| THPO | BARHL2 | 0.739313 | 3 | 0 | 3 |
| THPO | AICDA | 0.73782 | 3 | 0 | 3 |
| THPO | HMGB4 | 0.734677 | 3 | 0 | 3 |
| THPO | CCDC157 | 0.73195 | 4 | 0 | 4 |
| THPO | CALML6 | 0.73176 | 3 | 0 | 3 |
| THPO | ZNF81 | 0.71309 | 3 | 0 | 3 |
| THPO | L3MBTL1 | 0.702504 | 3 | 0 | 3 |
| THPO | CLEC18C | 0.700218 | 3 | 0 | 3 |
| THPO | TNP1 | 0.698415 | 5 | 0 | 4 |
| THPO | LIME1 | 0.696749 | 3 | 0 | 3 |
| THPO | SRD5A2 | 0.693245 | 4 | 0 | 3 |
| THPO | SLC1A7 | 0.689537 | 6 | 0 | 5 |
| THPO | STXBP6 | 0.689123 | 3 | 0 | 3 |
| THPO | ABCC6 | 0.687456 | 3 | 0 | 3 |
| THPO | KATNAL2 | 0.686119 | 3 | 0 | 3 |
For details and further investigation, click here
