Full name: thrombopoietin | Alias Symbol: TPO|MPLLG | ||
Type: protein-coding gene | Cytoband: 3q27.1 | ||
Entrez ID: 7066 | HGNC ID: HGNC:11795 | Ensembl Gene: ENSG00000090534 | OMIM ID: 600044 |
Drug and gene relationship at DGIdb |
THPO involved pathways:
KEGG pathway | Description | View |
---|---|---|
hsa04630 | Jak-STAT signaling pathway |
Expression of THPO:
Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
---|---|---|---|---|---|---|
GSE17351 | THPO | 7066 | 211831_s_at | -0.1841 | 0.4640 | |
GSE20347 | THPO | 7066 | 211831_s_at | -0.1522 | 0.0233 | |
GSE23400 | THPO | 7066 | 211831_s_at | -0.2532 | 0.0000 | |
GSE26886 | THPO | 7066 | 211831_s_at | -0.1953 | 0.1389 | |
GSE29001 | THPO | 7066 | 211831_s_at | -0.3172 | 0.0106 | |
GSE38129 | THPO | 7066 | 211831_s_at | -0.1865 | 0.0041 | |
GSE45670 | THPO | 7066 | 211831_s_at | 0.0365 | 0.7044 | |
GSE53622 | THPO | 7066 | 60745 | -0.2635 | 0.0266 | |
GSE53624 | THPO | 7066 | 60666 | -1.1158 | 0.0000 | |
GSE63941 | THPO | 7066 | 211831_s_at | 0.2482 | 0.1415 | |
GSE77861 | THPO | 7066 | 211831_s_at | -0.2463 | 0.0542 | |
GSE97050 | THPO | 7066 | A_24_P377124 | -0.0918 | 0.7546 | |
SRP159526 | THPO | 7066 | RNAseq | 1.2602 | 0.0345 | |
SRP219564 | THPO | 7066 | RNAseq | 0.1020 | 0.8704 | |
TCGA | THPO | 7066 | RNAseq | -0.5555 | 0.1944 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by THPO expression:
Note: Click image to view full size file.
Copy number change of THPO:
Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
---|---|---|---|---|---|---|
GSE15526 | THPO | 7066 | 25 | 0 | 5 | |
GSE20123 | THPO | 7066 | 25 | 0 | 5 | |
GSE43470 | THPO | 7066 | 25 | 0 | 18 | |
GSE46452 | THPO | 7066 | 19 | 1 | 39 | |
GSE47630 | THPO | 7066 | 27 | 2 | 11 | |
GSE54993 | THPO | 7066 | 1 | 19 | 50 | |
GSE54994 | THPO | 7066 | 41 | 0 | 12 | |
GSE60625 | THPO | 7066 | 0 | 6 | 5 | |
GSE74703 | THPO | 7066 | 21 | 0 | 15 | |
GSE74704 | THPO | 7066 | 17 | 0 | 3 | |
TCGA | THPO | 7066 | 77 | 0 | 19 |
Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.
Somatic mutations of THPO:
Generating mutation plots.
Highly correlated genes for THPO:
Showing top 20/807 corelated genes with mean PCC>0.5.
Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
---|---|---|---|---|---|
THPO | ATP6AP1L | 0.778487 | 3 | 0 | 3 |
THPO | KCNA6 | 0.770419 | 3 | 0 | 3 |
THPO | HMGCLL1 | 0.765258 | 3 | 0 | 3 |
THPO | NCR3 | 0.761773 | 3 | 0 | 3 |
THPO | SP7 | 0.752714 | 3 | 0 | 3 |
THPO | BARHL2 | 0.739313 | 3 | 0 | 3 |
THPO | AICDA | 0.73782 | 3 | 0 | 3 |
THPO | HMGB4 | 0.734677 | 3 | 0 | 3 |
THPO | CCDC157 | 0.73195 | 4 | 0 | 4 |
THPO | CALML6 | 0.73176 | 3 | 0 | 3 |
THPO | ZNF81 | 0.71309 | 3 | 0 | 3 |
THPO | L3MBTL1 | 0.702504 | 3 | 0 | 3 |
THPO | CLEC18C | 0.700218 | 3 | 0 | 3 |
THPO | TNP1 | 0.698415 | 5 | 0 | 4 |
THPO | LIME1 | 0.696749 | 3 | 0 | 3 |
THPO | SRD5A2 | 0.693245 | 4 | 0 | 3 |
THPO | SLC1A7 | 0.689537 | 6 | 0 | 5 |
THPO | STXBP6 | 0.689123 | 3 | 0 | 3 |
THPO | ABCC6 | 0.687456 | 3 | 0 | 3 |
THPO | KATNAL2 | 0.686119 | 3 | 0 | 3 |
For details and further investigation, click here