| Full name: phospholipase C delta 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 84812 | HGNC ID: HGNC:9062 | Ensembl Gene: ENSG00000115556 | OMIM ID: 605939 |
| Drug and gene relationship at DGIdb | |||
PLCD4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04919 | Thyroid hormone signaling pathway | |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
Expression of PLCD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLCD4 | 84812 | 224505_s_at | -1.3851 | 0.0481 | |
| GSE26886 | PLCD4 | 84812 | 224505_s_at | -0.2567 | 0.0696 | |
| GSE45670 | PLCD4 | 84812 | 224505_s_at | -0.7580 | 0.0029 | |
| GSE53622 | PLCD4 | 84812 | 105955 | -1.4413 | 0.0000 | |
| GSE53624 | PLCD4 | 84812 | 105955 | -1.6498 | 0.0000 | |
| GSE63941 | PLCD4 | 84812 | 224505_s_at | -0.6288 | 0.0118 | |
| GSE77861 | PLCD4 | 84812 | 224505_s_at | -0.2493 | 0.3149 | |
| GSE97050 | PLCD4 | 84812 | A_33_P3335825 | -0.4554 | 0.1980 | |
| SRP064894 | PLCD4 | 84812 | RNAseq | -1.3585 | 0.0001 | |
| SRP133303 | PLCD4 | 84812 | RNAseq | -1.7071 | 0.0006 | |
| SRP159526 | PLCD4 | 84812 | RNAseq | -3.4025 | 0.0000 | |
| SRP219564 | PLCD4 | 84812 | RNAseq | -0.9009 | 0.3897 | |
| TCGA | PLCD4 | 84812 | RNAseq | -0.3472 | 0.0108 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by PLCD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLCD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLCD4 | 84812 | 1 | 14 | 15 | |
| GSE20123 | PLCD4 | 84812 | 1 | 13 | 16 | |
| GSE43470 | PLCD4 | 84812 | 1 | 7 | 35 | |
| GSE46452 | PLCD4 | 84812 | 0 | 5 | 54 | |
| GSE47630 | PLCD4 | 84812 | 4 | 5 | 31 | |
| GSE54993 | PLCD4 | 84812 | 1 | 2 | 67 | |
| GSE54994 | PLCD4 | 84812 | 8 | 10 | 35 | |
| GSE60625 | PLCD4 | 84812 | 0 | 3 | 8 | |
| GSE74703 | PLCD4 | 84812 | 1 | 5 | 30 | |
| GSE74704 | PLCD4 | 84812 | 1 | 7 | 12 | |
| TCGA | PLCD4 | 84812 | 11 | 27 | 58 |
Total number of gains: 29; Total number of losses: 98; Total Number of normals: 361.
Somatic mutations of PLCD4:
Generating mutation plots.
Highly correlated genes for PLCD4:
Showing top 20/353 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLCD4 | CALCOCO1 | 0.726385 | 4 | 0 | 4 |
| PLCD4 | CRYAB | 0.724936 | 3 | 0 | 3 |
| PLCD4 | LDB3 | 0.723421 | 3 | 0 | 3 |
| PLCD4 | CASQ2 | 0.71487 | 5 | 0 | 5 |
| PLCD4 | SORCS1 | 0.714123 | 3 | 0 | 3 |
| PLCD4 | CITED2 | 0.710451 | 3 | 0 | 3 |
| PLCD4 | KCNB1 | 0.70336 | 3 | 0 | 3 |
| PLCD4 | KLHL34 | 0.701144 | 3 | 0 | 3 |
| PLCD4 | CPNE6 | 0.69866 | 3 | 0 | 3 |
| PLCD4 | FOXO4 | 0.695986 | 4 | 0 | 4 |
| PLCD4 | MOB2 | 0.694721 | 5 | 0 | 5 |
| PLCD4 | PTCHD1 | 0.682563 | 4 | 0 | 4 |
| PLCD4 | SORBS2 | 0.677402 | 3 | 0 | 3 |
| PLCD4 | CASP12 | 0.676446 | 4 | 0 | 3 |
| PLCD4 | KCNQ4 | 0.674377 | 3 | 0 | 3 |
| PLCD4 | HCRT | 0.674192 | 3 | 0 | 3 |
| PLCD4 | ADCYAP1R1 | 0.672233 | 3 | 0 | 3 |
| PLCD4 | C22orf23 | 0.670875 | 3 | 0 | 3 |
| PLCD4 | LGI1 | 0.667475 | 4 | 0 | 4 |
| PLCD4 | MAP6 | 0.665403 | 4 | 0 | 4 |
For details and further investigation, click here
