| Full name: cytochrome P450 family 2 subfamily E member 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q26.3 | ||
| Entrez ID: 1571 | HGNC ID: HGNC:2631 | Ensembl Gene: ENSG00000130649 | OMIM ID: 124040 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2E1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2E1 | 1571 | 209975_at | -1.5372 | 0.3477 | |
| GSE20347 | CYP2E1 | 1571 | 209975_at | -2.2102 | 0.0000 | |
| GSE23400 | CYP2E1 | 1571 | 209975_at | -1.2139 | 0.0000 | |
| GSE26886 | CYP2E1 | 1571 | 209975_at | -3.3029 | 0.0000 | |
| GSE29001 | CYP2E1 | 1571 | 209975_at | -2.7494 | 0.0000 | |
| GSE38129 | CYP2E1 | 1571 | 209975_at | -1.8099 | 0.0000 | |
| GSE45670 | CYP2E1 | 1571 | 209975_at | -1.5931 | 0.0066 | |
| GSE53622 | CYP2E1 | 1571 | 28119 | -2.4587 | 0.0000 | |
| GSE53624 | CYP2E1 | 1571 | 28119 | -3.0798 | 0.0000 | |
| GSE63941 | CYP2E1 | 1571 | 209975_at | -0.3200 | 0.2587 | |
| GSE77861 | CYP2E1 | 1571 | 209975_at | -0.9092 | 0.0065 | |
| GSE97050 | CYP2E1 | 1571 | A_24_P394940 | -0.2150 | 0.5057 | |
| SRP007169 | CYP2E1 | 1571 | RNAseq | -4.2996 | 0.0000 | |
| SRP008496 | CYP2E1 | 1571 | RNAseq | -4.7052 | 0.0000 | |
| SRP064894 | CYP2E1 | 1571 | RNAseq | -2.9038 | 0.0000 | |
| SRP133303 | CYP2E1 | 1571 | RNAseq | -2.0857 | 0.0000 | |
| SRP159526 | CYP2E1 | 1571 | RNAseq | -3.1304 | 0.0000 | |
| SRP219564 | CYP2E1 | 1571 | RNAseq | -2.0936 | 0.0056 | |
| TCGA | CYP2E1 | 1571 | RNAseq | -0.9890 | 0.0165 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by CYP2E1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP2E1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2E1 | 1571 | 4 | 5 | 21 | |
| GSE20123 | CYP2E1 | 1571 | 4 | 6 | 20 | |
| GSE43470 | CYP2E1 | 1571 | 0 | 9 | 34 | |
| GSE46452 | CYP2E1 | 1571 | 1 | 11 | 47 | |
| GSE47630 | CYP2E1 | 1571 | 4 | 13 | 23 | |
| GSE54993 | CYP2E1 | 1571 | 8 | 2 | 60 | |
| GSE54994 | CYP2E1 | 1571 | 1 | 9 | 43 | |
| GSE60625 | CYP2E1 | 1571 | 0 | 0 | 11 | |
| GSE74703 | CYP2E1 | 1571 | 0 | 7 | 29 | |
| GSE74704 | CYP2E1 | 1571 | 3 | 3 | 14 | |
| TCGA | CYP2E1 | 1571 | 7 | 28 | 61 |
Total number of gains: 32; Total number of losses: 93; Total Number of normals: 363.
Somatic mutations of CYP2E1:
Generating mutation plots.
Highly correlated genes for CYP2E1:
Showing top 20/694 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2E1 | C5orf66-AS1 | 0.815529 | 6 | 0 | 6 |
| CYP2E1 | SLC37A1 | 0.806481 | 11 | 0 | 11 |
| CYP2E1 | FAM3B | 0.800645 | 6 | 0 | 6 |
| CYP2E1 | EPS8L2 | 0.782993 | 11 | 0 | 11 |
| CYP2E1 | CLIC3 | 0.780007 | 8 | 0 | 8 |
| CYP2E1 | SNORA68 | 0.776276 | 4 | 0 | 4 |
| CYP2E1 | ANXA9 | 0.774354 | 10 | 0 | 10 |
| CYP2E1 | RANBP9 | 0.772773 | 10 | 0 | 10 |
| CYP2E1 | GYS2 | 0.769448 | 10 | 0 | 10 |
| CYP2E1 | CHP1 | 0.768401 | 10 | 0 | 10 |
| CYP2E1 | CRISP3 | 0.766424 | 10 | 0 | 10 |
| CYP2E1 | SMAGP | 0.766416 | 11 | 0 | 10 |
| CYP2E1 | EXPH5 | 0.766266 | 10 | 0 | 10 |
| CYP2E1 | UBN2 | 0.765958 | 3 | 0 | 3 |
| CYP2E1 | UBL3 | 0.764008 | 10 | 0 | 10 |
| CYP2E1 | SH3BGRL2 | 0.762626 | 6 | 0 | 6 |
| CYP2E1 | FAM3D | 0.761349 | 7 | 0 | 6 |
| CYP2E1 | KIAA1211L | 0.761282 | 6 | 0 | 6 |
| CYP2E1 | PHACTR4 | 0.760933 | 10 | 0 | 10 |
| CYP2E1 | FUT3 | 0.759803 | 11 | 0 | 10 |
For details and further investigation, click here
