CDKN2A

 

Full name: cyclin dependent kinase inhibitor 2A Alias Symbol: CDK4I|p16|INK4a|MTS1|CMM2|ARF|p19|p14|INK4|p16INK4a|p19Arf|p14ARF
Type: protein-coding gene Cytoband: 9p21.3
Entrez ID: 1029 HGNC ID: HGNC:1787 Ensembl Gene: ENSG00000147889 OMIM ID: 600160
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CDKN2A involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05223Non-small cell lung cancer

 

Expression of CDKN2A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDKN2A 1029 209644_x_at 0.0145 0.9957
GSE20347 CDKN2A 1029 209644_x_at 1.0114 0.0461
GSE23400 CDKN2A 1029 209644_x_at 0.5763 0.0075
GSE26886 CDKN2A 1029 209644_x_at 0.6043 0.1686
GSE29001 CDKN2A 1029 207039_at 0.8528 0.4379
GSE38129 CDKN2A 1029 209644_x_at 0.8490 0.0682
GSE45670 CDKN2A 1029 209644_x_at 0.6191 0.2462
GSE53622 CDKN2A 1029 55942 0.3446 0.2942
GSE53624 CDKN2A 1029 55942 -0.0520 0.8415
GSE63941 CDKN2A 1029 209644_x_at -0.2444 0.9008
GSE77861 CDKN2A 1029 209644_x_at -0.0772 0.9244
GSE97050 CDKN2A 1029 A_33_P3411628 -0.2757 0.6272
SRP007169 CDKN2A 1029 RNAseq 2.9720 0.0000
SRP008496 CDKN2A 1029 RNAseq 2.5122 0.0009
SRP064894 CDKN2A 1029 RNAseq 4.2805 0.0000
SRP133303 CDKN2A 1029 RNAseq 1.4525 0.1148
SRP159526 CDKN2A 1029 RNAseq 1.0344 0.2884
SRP219564 CDKN2A 1029 RNAseq 2.1568 0.0340
TCGA CDKN2A 1029 RNAseq 0.1856 0.6723

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by CDKN2A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDKN2A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDKN2A 1029 1 22 7
GSE20123 CDKN2A 1029 1 22 7
GSE43470 CDKN2A 1029 1 18 24
GSE46452 CDKN2A 1029 1 28 30
GSE47630 CDKN2A 1029 1 29 10
GSE54993 CDKN2A 1029 9 0 61
GSE54994 CDKN2A 1029 3 28 22
GSE60625 CDKN2A 1029 3 0 8
GSE74703 CDKN2A 1029 1 15 20
GSE74704 CDKN2A 1029 0 15 5
TCGA CDKN2A 1029 1 77 18

Total number of gains: 22; Total number of losses: 254; Total Number of normals: 212.  

 

Somatic mutations of CDKN2A:

 

Generating mutation plots.

 

Highly correlated genes for CDKN2A:

 

Showing all 11 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDKN2APANX20.634549303
CDKN2AC11orf710.63303
CDKN2ASLAMF90.597832303
CDKN2AACHE0.596461303
CDKN2ACPNE70.581305303
CDKN2ANOXA10.580361303
CDKN2AJRK0.563251303
CDKN2AUCHL10.552296503
CDKN2ARHPN10.549673403
CDKN2ACA90.516713403
CDKN2ACDKN2B0.502053703

For details and further investigation, click here