| Full name: ubiquitin C-terminal hydrolase L1 | Alias Symbol: PGP9.5|Uch-L1 | ||
| Type: protein-coding gene | Cytoband: 4p13 | ||
| Entrez ID: 7345 | HGNC ID: HGNC:12513 | Ensembl Gene: ENSG00000154277 | OMIM ID: 191342 |
| Drug and gene relationship at DGIdb | |||
Expression of UCHL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UCHL1 | 7345 | 201387_s_at | 1.6780 | 0.3618 | |
| GSE20347 | UCHL1 | 7345 | 201387_s_at | 2.5620 | 0.0000 | |
| GSE23400 | UCHL1 | 7345 | 201387_s_at | 1.2285 | 0.0000 | |
| GSE26886 | UCHL1 | 7345 | 201387_s_at | 1.4783 | 0.0043 | |
| GSE29001 | UCHL1 | 7345 | 201387_s_at | 1.5338 | 0.0136 | |
| GSE38129 | UCHL1 | 7345 | 201387_s_at | 2.5419 | 0.0000 | |
| GSE45670 | UCHL1 | 7345 | 201387_s_at | 1.0613 | 0.2615 | |
| GSE53622 | UCHL1 | 7345 | 99823 | 2.0281 | 0.0000 | |
| GSE53624 | UCHL1 | 7345 | 99823 | 2.4281 | 0.0000 | |
| GSE63941 | UCHL1 | 7345 | 201387_s_at | -3.3159 | 0.2066 | |
| GSE77861 | UCHL1 | 7345 | 201387_s_at | 2.2004 | 0.0722 | |
| GSE97050 | UCHL1 | 7345 | A_23_P132956 | 0.3235 | 0.5705 | |
| SRP007169 | UCHL1 | 7345 | RNAseq | 7.1841 | 0.0000 | |
| SRP008496 | UCHL1 | 7345 | RNAseq | 6.7838 | 0.0000 | |
| SRP064894 | UCHL1 | 7345 | RNAseq | 3.2908 | 0.0000 | |
| SRP133303 | UCHL1 | 7345 | RNAseq | 1.8473 | 0.0001 | |
| SRP159526 | UCHL1 | 7345 | RNAseq | 4.8023 | 0.0000 | |
| TCGA | UCHL1 | 7345 | RNAseq | 0.6887 | 0.0118 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by UCHL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UCHL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UCHL1 | 7345 | 0 | 16 | 14 | |
| GSE20123 | UCHL1 | 7345 | 0 | 16 | 14 | |
| GSE43470 | UCHL1 | 7345 | 0 | 14 | 29 | |
| GSE46452 | UCHL1 | 7345 | 1 | 36 | 22 | |
| GSE47630 | UCHL1 | 7345 | 1 | 19 | 20 | |
| GSE54993 | UCHL1 | 7345 | 7 | 0 | 63 | |
| GSE54994 | UCHL1 | 7345 | 4 | 9 | 40 | |
| GSE60625 | UCHL1 | 7345 | 0 | 0 | 11 | |
| GSE74703 | UCHL1 | 7345 | 0 | 12 | 24 | |
| GSE74704 | UCHL1 | 7345 | 0 | 9 | 11 | |
| TCGA | UCHL1 | 7345 | 11 | 43 | 42 |
Total number of gains: 24; Total number of losses: 174; Total Number of normals: 290.
Somatic mutations of UCHL1:
Generating mutation plots.
Highly correlated genes for UCHL1:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UCHL1 | LINC00592 | 0.689935 | 3 | 0 | 3 |
| UCHL1 | FADS1 | 0.684473 | 4 | 0 | 4 |
| UCHL1 | SOCS3 | 0.665249 | 3 | 0 | 3 |
| UCHL1 | CYBRD1 | 0.657941 | 4 | 0 | 4 |
| UCHL1 | ANXA4 | 0.64768 | 3 | 0 | 3 |
| UCHL1 | TEAD2 | 0.642906 | 5 | 0 | 5 |
| UCHL1 | GAA | 0.639379 | 10 | 0 | 8 |
| UCHL1 | RAB34 | 0.636718 | 3 | 0 | 3 |
| UCHL1 | DGKD | 0.636085 | 6 | 0 | 5 |
| UCHL1 | ALDH1L2 | 0.63467 | 4 | 0 | 3 |
| UCHL1 | FCGR3A | 0.633724 | 3 | 0 | 3 |
| UCHL1 | TSPYL2 | 0.632207 | 3 | 0 | 3 |
| UCHL1 | CXCR4 | 0.625922 | 3 | 0 | 3 |
| UCHL1 | EML1 | 0.621642 | 4 | 0 | 4 |
| UCHL1 | TNFRSF1B | 0.621516 | 4 | 0 | 3 |
| UCHL1 | RNF175 | 0.621196 | 4 | 0 | 3 |
| UCHL1 | CDH11 | 0.620997 | 10 | 0 | 8 |
| UCHL1 | RAB2B | 0.620849 | 4 | 0 | 3 |
| UCHL1 | PLAUR | 0.6188 | 9 | 0 | 6 |
| UCHL1 | TXNRD1 | 0.618532 | 13 | 0 | 11 |
For details and further investigation, click here
