| Full name: cytochrome P450 family 8 subfamily B member 1 | Alias Symbol: CYP12 | ||
| Type: protein-coding gene | Cytoband: 3p22.1 | ||
| Entrez ID: 1582 | HGNC ID: HGNC:2653 | Ensembl Gene: ENSG00000180432 | OMIM ID: 602172 |
| Drug and gene relationship at DGIdb | |||
CYP8B1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of CYP8B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP8B1 | 1582 | 232494_at | 0.0166 | 0.9645 | |
| GSE26886 | CYP8B1 | 1582 | 232494_at | -0.0375 | 0.7614 | |
| GSE45670 | CYP8B1 | 1582 | 232494_at | -0.0272 | 0.8161 | |
| GSE53622 | CYP8B1 | 1582 | 11843 | -0.0773 | 0.4783 | |
| GSE53624 | CYP8B1 | 1582 | 11843 | 0.0521 | 0.4810 | |
| GSE63941 | CYP8B1 | 1582 | 232494_at | -0.2112 | 0.1862 | |
| GSE77861 | CYP8B1 | 1582 | 232494_at | -0.0181 | 0.9012 | |
| SRP133303 | CYP8B1 | 1582 | RNAseq | -0.4853 | 0.0397 | |
| SRP159526 | CYP8B1 | 1582 | RNAseq | -0.1101 | 0.8488 | |
| SRP193095 | CYP8B1 | 1582 | RNAseq | -0.3639 | 0.0205 | |
| TCGA | CYP8B1 | 1582 | RNAseq | -1.5357 | 0.0123 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CYP8B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP8B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP8B1 | 1582 | 0 | 19 | 11 | |
| GSE20123 | CYP8B1 | 1582 | 0 | 19 | 11 | |
| GSE43470 | CYP8B1 | 1582 | 0 | 20 | 23 | |
| GSE46452 | CYP8B1 | 1582 | 2 | 17 | 40 | |
| GSE47630 | CYP8B1 | 1582 | 1 | 24 | 15 | |
| GSE54993 | CYP8B1 | 1582 | 7 | 2 | 61 | |
| GSE54994 | CYP8B1 | 1582 | 1 | 34 | 18 | |
| GSE60625 | CYP8B1 | 1582 | 5 | 0 | 6 | |
| GSE74703 | CYP8B1 | 1582 | 0 | 16 | 20 | |
| GSE74704 | CYP8B1 | 1582 | 0 | 13 | 7 | |
| TCGA | CYP8B1 | 1582 | 1 | 71 | 24 |
Total number of gains: 17; Total number of losses: 235; Total Number of normals: 236.
Somatic mutations of CYP8B1:
Generating mutation plots.
Highly correlated genes for CYP8B1:
Showing all 19 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP8B1 | MORF4L2-AS1 | 0.627512 | 3 | 0 | 3 |
| CYP8B1 | C1orf94 | 0.621055 | 4 | 0 | 3 |
| CYP8B1 | LINC01312 | 0.620272 | 3 | 0 | 3 |
| CYP8B1 | ODF1 | 0.600939 | 4 | 0 | 3 |
| CYP8B1 | CC2D2B | 0.599707 | 3 | 0 | 3 |
| CYP8B1 | SPATA24 | 0.594716 | 5 | 0 | 4 |
| CYP8B1 | GRIN3A | 0.5853 | 3 | 0 | 3 |
| CYP8B1 | TAC3 | 0.579295 | 4 | 0 | 3 |
| CYP8B1 | AK7 | 0.574417 | 4 | 0 | 3 |
| CYP8B1 | TTLL10 | 0.55764 | 3 | 0 | 3 |
| CYP8B1 | LETM2 | 0.538589 | 4 | 0 | 3 |
| CYP8B1 | POU5F2 | 0.53774 | 3 | 0 | 3 |
| CYP8B1 | KLLN | 0.536585 | 5 | 0 | 3 |
| CYP8B1 | KCNIP2-AS1 | 0.530312 | 3 | 0 | 3 |
| CYP8B1 | KRTAP4-12 | 0.5301 | 4 | 0 | 3 |
| CYP8B1 | RNASE3 | 0.528686 | 3 | 0 | 3 |
| CYP8B1 | CA14 | 0.524246 | 4 | 0 | 3 |
| CYP8B1 | DSCAM | 0.515269 | 4 | 0 | 3 |
| CYP8B1 | HNF1B | 0.514166 | 4 | 0 | 3 |
For details and further investigation, click here
