| Full name: leucine zipper and EF-hand containing transmembrane protein 2 | Alias Symbol: FLJ25409|SLC55A2 | ||
| Type: protein-coding gene | Cytoband: 8p11.23 | ||
| Entrez ID: 137994 | HGNC ID: HGNC:14648 | Ensembl Gene: ENSG00000165046 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of LETM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LETM2 | 137994 | 1557415_s_at | 0.3187 | 0.3775 | |
| GSE26886 | LETM2 | 137994 | 1557415_s_at | 0.0500 | 0.7644 | |
| GSE45670 | LETM2 | 137994 | 1557415_s_at | 0.2867 | 0.1109 | |
| GSE63941 | LETM2 | 137994 | 1557415_s_at | -0.7191 | 0.0057 | |
| GSE77861 | LETM2 | 137994 | 1557415_s_at | 0.0380 | 0.7877 | |
| GSE97050 | LETM2 | 137994 | A_23_P348264 | 0.5400 | 0.1618 | |
| SRP007169 | LETM2 | 137994 | RNAseq | 1.2533 | 0.0497 | |
| SRP064894 | LETM2 | 137994 | RNAseq | -0.1946 | 0.2962 | |
| SRP133303 | LETM2 | 137994 | RNAseq | 0.3477 | 0.0160 | |
| SRP159526 | LETM2 | 137994 | RNAseq | 0.7883 | 0.1344 | |
| SRP193095 | LETM2 | 137994 | RNAseq | 0.2205 | 0.0915 | |
| SRP219564 | LETM2 | 137994 | RNAseq | 0.2029 | 0.7231 | |
| TCGA | LETM2 | 137994 | RNAseq | 0.1850 | 0.2807 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LETM2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LETM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LETM2 | 137994 | 10 | 4 | 16 | |
| GSE20123 | LETM2 | 137994 | 11 | 4 | 15 | |
| GSE43470 | LETM2 | 137994 | 8 | 6 | 29 | |
| GSE46452 | LETM2 | 137994 | 21 | 5 | 33 | |
| GSE47630 | LETM2 | 137994 | 12 | 7 | 21 | |
| GSE54993 | LETM2 | 137994 | 2 | 16 | 52 | |
| GSE54994 | LETM2 | 137994 | 17 | 7 | 29 | |
| GSE60625 | LETM2 | 137994 | 3 | 0 | 8 | |
| GSE74703 | LETM2 | 137994 | 8 | 5 | 23 | |
| GSE74704 | LETM2 | 137994 | 9 | 1 | 10 | |
| TCGA | LETM2 | 137994 | 37 | 21 | 38 |
Total number of gains: 138; Total number of losses: 76; Total Number of normals: 274.
Somatic mutations of LETM2:
Generating mutation plots.
Highly correlated genes for LETM2:
Showing top 20/150 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LETM2 | UBE3C | 0.809317 | 3 | 0 | 3 |
| LETM2 | RCN2 | 0.788237 | 3 | 0 | 3 |
| LETM2 | STOML1 | 0.783483 | 3 | 0 | 3 |
| LETM2 | IFFO2 | 0.780566 | 3 | 0 | 3 |
| LETM2 | SHC1 | 0.77204 | 3 | 0 | 3 |
| LETM2 | HIP1 | 0.762726 | 3 | 0 | 3 |
| LETM2 | SYDE1 | 0.740969 | 3 | 0 | 3 |
| LETM2 | RCAN1 | 0.734736 | 3 | 0 | 3 |
| LETM2 | THAP10 | 0.730701 | 3 | 0 | 3 |
| LETM2 | XPO6 | 0.729629 | 3 | 0 | 3 |
| LETM2 | TGM2 | 0.727114 | 3 | 0 | 3 |
| LETM2 | MPP1 | 0.722067 | 3 | 0 | 3 |
| LETM2 | RHOC | 0.721209 | 3 | 0 | 3 |
| LETM2 | CNRIP1 | 0.718328 | 3 | 0 | 3 |
| LETM2 | SIDT2 | 0.716553 | 3 | 0 | 3 |
| LETM2 | CCDC88A | 0.714619 | 3 | 0 | 3 |
| LETM2 | YLPM1 | 0.714371 | 3 | 0 | 3 |
| LETM2 | PDE5A | 0.708944 | 3 | 0 | 3 |
| LETM2 | SORBS3 | 0.708797 | 3 | 0 | 3 |
| LETM2 | COMMD4 | 0.707847 | 3 | 0 | 3 |
For details and further investigation, click here
