| Full name: glutamate ionotropic receptor NMDA type subunit 3A | Alias Symbol: GluN3A | ||
| Type: protein-coding gene | Cytoband: 9q31.1 | ||
| Entrez ID: 116443 | HGNC ID: HGNC:16767 | Ensembl Gene: ENSG00000198785 | OMIM ID: 606650 |
| Drug and gene relationship at DGIdb | |||
GRIN3A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04724 | Glutamatergic synapse | |
| hsa05030 | Cocaine addiction | |
| hsa05031 | Amphetamine addiction | |
| hsa05034 | Alcoholism |
Expression of GRIN3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRIN3A | 116443 | 233220_at | -0.0741 | 0.7536 | |
| GSE26886 | GRIN3A | 116443 | 233220_at | -0.0334 | 0.8174 | |
| GSE45670 | GRIN3A | 116443 | 233220_at | 0.0098 | 0.9230 | |
| GSE53622 | GRIN3A | 116443 | 49024 | -0.7303 | 0.0000 | |
| GSE53624 | GRIN3A | 116443 | 49024 | -0.4074 | 0.0000 | |
| GSE63941 | GRIN3A | 116443 | 233220_at | -0.2767 | 0.0517 | |
| GSE77861 | GRIN3A | 116443 | 233220_at | -0.0672 | 0.6246 | |
| GSE97050 | GRIN3A | 116443 | A_23_P347541 | -0.1003 | 0.6549 | |
| SRP133303 | GRIN3A | 116443 | RNAseq | -0.5659 | 0.0321 | |
| SRP193095 | GRIN3A | 116443 | RNAseq | -0.0302 | 0.8887 | |
| SRP219564 | GRIN3A | 116443 | RNAseq | 0.0242 | 0.9613 | |
| TCGA | GRIN3A | 116443 | RNAseq | -0.3109 | 0.0907 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GRIN3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRIN3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRIN3A | 116443 | 4 | 10 | 16 | |
| GSE20123 | GRIN3A | 116443 | 5 | 9 | 16 | |
| GSE43470 | GRIN3A | 116443 | 6 | 3 | 34 | |
| GSE46452 | GRIN3A | 116443 | 6 | 13 | 40 | |
| GSE47630 | GRIN3A | 116443 | 1 | 17 | 22 | |
| GSE54993 | GRIN3A | 116443 | 3 | 3 | 64 | |
| GSE54994 | GRIN3A | 116443 | 9 | 11 | 33 | |
| GSE60625 | GRIN3A | 116443 | 0 | 0 | 11 | |
| GSE74703 | GRIN3A | 116443 | 5 | 3 | 28 | |
| GSE74704 | GRIN3A | 116443 | 2 | 6 | 12 | |
| TCGA | GRIN3A | 116443 | 28 | 21 | 47 |
Total number of gains: 69; Total number of losses: 96; Total Number of normals: 323.
Somatic mutations of GRIN3A:
Generating mutation plots.
Highly correlated genes for GRIN3A:
Showing top 20/192 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRIN3A | KCNK2 | 0.811833 | 3 | 0 | 3 |
| GRIN3A | SGIP1 | 0.743177 | 3 | 0 | 3 |
| GRIN3A | ZNF461 | 0.736364 | 3 | 0 | 3 |
| GRIN3A | KCNC4 | 0.732206 | 3 | 0 | 3 |
| GRIN3A | RTN2 | 0.731133 | 3 | 0 | 3 |
| GRIN3A | CLMP | 0.724505 | 3 | 0 | 3 |
| GRIN3A | BRK1 | 0.718955 | 3 | 0 | 3 |
| GRIN3A | ARHGAP24 | 0.718306 | 3 | 0 | 3 |
| GRIN3A | STARD13 | 0.716889 | 3 | 0 | 3 |
| GRIN3A | DNAH11 | 0.714255 | 3 | 0 | 3 |
| GRIN3A | LIN7A | 0.710908 | 3 | 0 | 3 |
| GRIN3A | SYDE1 | 0.705985 | 4 | 0 | 4 |
| GRIN3A | CNST | 0.704128 | 3 | 0 | 3 |
| GRIN3A | SEMA6A | 0.700582 | 3 | 0 | 3 |
| GRIN3A | MYOZ2 | 0.699279 | 3 | 0 | 3 |
| GRIN3A | MAGI1 | 0.694503 | 3 | 0 | 3 |
| GRIN3A | GORASP1 | 0.694458 | 3 | 0 | 3 |
| GRIN3A | UBXN10 | 0.690571 | 3 | 0 | 3 |
| GRIN3A | TCF7L1 | 0.687046 | 3 | 0 | 3 |
| GRIN3A | GPA33 | 0.685938 | 3 | 0 | 3 |
For details and further investigation, click here
