| Full name: tachykinin precursor 3 | Alias Symbol: ZNEUROK1|NKB|NK3 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 6866 | HGNC ID: HGNC:11521 | Ensembl Gene: ENSG00000166863 | OMIM ID: 162330 |
| Drug and gene relationship at DGIdb | |||
Expression of TAC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TAC3 | 6866 | 219992_at | -0.1733 | 0.5123 | |
| GSE20347 | TAC3 | 6866 | 219992_at | -0.2344 | 0.0157 | |
| GSE23400 | TAC3 | 6866 | 219992_at | -0.1620 | 0.0000 | |
| GSE26886 | TAC3 | 6866 | 219992_at | -0.0702 | 0.6277 | |
| GSE29001 | TAC3 | 6866 | 219992_at | -0.1772 | 0.3524 | |
| GSE38129 | TAC3 | 6866 | 219992_at | -0.2497 | 0.0011 | |
| GSE45670 | TAC3 | 6866 | 219992_at | 0.1586 | 0.1983 | |
| GSE53622 | TAC3 | 6866 | 1119 | -0.3232 | 0.0322 | |
| GSE53624 | TAC3 | 6866 | 55165 | -0.2826 | 0.0782 | |
| GSE63941 | TAC3 | 6866 | 219992_at | -0.0443 | 0.8429 | |
| GSE77861 | TAC3 | 6866 | 219992_at | -0.2739 | 0.0428 | |
| TCGA | TAC3 | 6866 | RNAseq | -4.0142 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TAC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TAC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TAC3 | 6866 | 7 | 1 | 22 | |
| GSE20123 | TAC3 | 6866 | 7 | 0 | 23 | |
| GSE43470 | TAC3 | 6866 | 3 | 0 | 40 | |
| GSE46452 | TAC3 | 6866 | 8 | 1 | 50 | |
| GSE47630 | TAC3 | 6866 | 10 | 2 | 28 | |
| GSE54993 | TAC3 | 6866 | 0 | 5 | 65 | |
| GSE54994 | TAC3 | 6866 | 4 | 1 | 48 | |
| GSE60625 | TAC3 | 6866 | 0 | 0 | 11 | |
| GSE74703 | TAC3 | 6866 | 3 | 0 | 33 | |
| GSE74704 | TAC3 | 6866 | 4 | 0 | 16 | |
| TCGA | TAC3 | 6866 | 14 | 10 | 72 |
Total number of gains: 60; Total number of losses: 20; Total Number of normals: 408.
Somatic mutations of TAC3:
Generating mutation plots.
Highly correlated genes for TAC3:
Showing top 20/668 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TAC3 | PRSS33 | 0.708391 | 4 | 0 | 3 |
| TAC3 | LINC01119 | 0.696592 | 3 | 0 | 3 |
| TAC3 | PHLDB1 | 0.692304 | 8 | 0 | 7 |
| TAC3 | ANKRD34C | 0.68354 | 4 | 0 | 4 |
| TAC3 | CD300LB | 0.682614 | 4 | 0 | 4 |
| TAC3 | PF4 | 0.68035 | 6 | 0 | 5 |
| TAC3 | RPS6KA6 | 0.678785 | 3 | 0 | 3 |
| TAC3 | PSG7 | 0.673262 | 4 | 0 | 3 |
| TAC3 | CNR2 | 0.67226 | 8 | 0 | 8 |
| TAC3 | ADRB3 | 0.671447 | 4 | 0 | 3 |
| TAC3 | STMN2 | 0.664043 | 4 | 0 | 4 |
| TAC3 | SCNN1G | 0.663349 | 6 | 0 | 5 |
| TAC3 | CCDC7 | 0.660404 | 5 | 0 | 4 |
| TAC3 | USP2 | 0.658932 | 4 | 0 | 3 |
| TAC3 | MUC5AC | 0.65768 | 6 | 0 | 5 |
| TAC3 | CST8 | 0.655812 | 7 | 0 | 6 |
| TAC3 | NTRK3 | 0.654239 | 3 | 0 | 3 |
| TAC3 | KCNMB2 | 0.652616 | 5 | 0 | 3 |
| TAC3 | TULP2 | 0.651784 | 6 | 0 | 5 |
| TAC3 | BRS3 | 0.648381 | 3 | 0 | 3 |
For details and further investigation, click here
