| Full name: dihydrolipoamide branched chain transacylase E2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p21.2 | ||
| Entrez ID: 1629 | HGNC ID: HGNC:2698 | Ensembl Gene: ENSG00000137992 | OMIM ID: 248610 |
| Drug and gene relationship at DGIdb | |||
Expression of DBT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DBT | 1629 | 205370_x_at | 0.1747 | 0.7379 | |
| GSE20347 | DBT | 1629 | 205370_x_at | 0.3797 | 0.0386 | |
| GSE23400 | DBT | 1629 | 205370_x_at | 0.0537 | 0.4919 | |
| GSE26886 | DBT | 1629 | 205370_x_at | -0.0140 | 0.9581 | |
| GSE29001 | DBT | 1629 | 205370_x_at | 0.1976 | 0.2309 | |
| GSE38129 | DBT | 1629 | 205370_x_at | 0.1830 | 0.3139 | |
| GSE45670 | DBT | 1629 | 205370_x_at | 0.2097 | 0.0321 | |
| GSE53622 | DBT | 1629 | 26337 | -0.9807 | 0.0000 | |
| GSE53624 | DBT | 1629 | 26337 | -0.3724 | 0.0000 | |
| GSE63941 | DBT | 1629 | 205370_x_at | 0.0131 | 0.9569 | |
| GSE77861 | DBT | 1629 | 205370_x_at | 0.6189 | 0.0968 | |
| GSE97050 | DBT | 1629 | A_33_P3308949 | -0.8837 | 0.0997 | |
| SRP007169 | DBT | 1629 | RNAseq | -0.3277 | 0.4437 | |
| SRP008496 | DBT | 1629 | RNAseq | -0.3835 | 0.0886 | |
| SRP064894 | DBT | 1629 | RNAseq | -0.0588 | 0.6680 | |
| SRP133303 | DBT | 1629 | RNAseq | -0.0747 | 0.4848 | |
| SRP159526 | DBT | 1629 | RNAseq | -0.8105 | 0.0000 | |
| SRP193095 | DBT | 1629 | RNAseq | -0.4217 | 0.0000 | |
| SRP219564 | DBT | 1629 | RNAseq | -0.6464 | 0.0944 | |
| TCGA | DBT | 1629 | RNAseq | -0.3578 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DBT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DBT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DBT | 1629 | 0 | 10 | 20 | |
| GSE20123 | DBT | 1629 | 0 | 10 | 20 | |
| GSE43470 | DBT | 1629 | 2 | 6 | 35 | |
| GSE46452 | DBT | 1629 | 1 | 1 | 57 | |
| GSE47630 | DBT | 1629 | 9 | 5 | 26 | |
| GSE54993 | DBT | 1629 | 0 | 1 | 69 | |
| GSE54994 | DBT | 1629 | 6 | 3 | 44 | |
| GSE60625 | DBT | 1629 | 0 | 0 | 11 | |
| GSE74703 | DBT | 1629 | 1 | 5 | 30 | |
| GSE74704 | DBT | 1629 | 0 | 6 | 14 | |
| TCGA | DBT | 1629 | 8 | 25 | 63 |
Total number of gains: 27; Total number of losses: 72; Total Number of normals: 389.
Somatic mutations of DBT:
Generating mutation plots.
Highly correlated genes for DBT:
Showing top 20/244 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DBT | ZNF611 | 0.907133 | 8 | 0 | 8 |
| DBT | MZT2B | 0.892314 | 9 | 0 | 9 |
| DBT | SLC22A3 | 0.891548 | 4 | 0 | 4 |
| DBT | C9orf64 | 0.841478 | 5 | 0 | 5 |
| DBT | SLC35E1 | 0.838975 | 10 | 0 | 9 |
| DBT | DDX59 | 0.82179 | 5 | 0 | 5 |
| DBT | DIP2A | 0.815816 | 11 | 0 | 10 |
| DBT | FUT8-AS1 | 0.812915 | 4 | 0 | 4 |
| DBT | UACA | 0.796306 | 4 | 0 | 4 |
| DBT | MAGI1 | 0.784655 | 5 | 0 | 5 |
| DBT | PPIG | 0.76774 | 4 | 0 | 4 |
| DBT | SSBP3-AS1 | 0.767711 | 4 | 0 | 4 |
| DBT | CMBL | 0.766479 | 5 | 0 | 4 |
| DBT | WAC-AS1 | 0.763599 | 3 | 0 | 3 |
| DBT | TRMT10B | 0.755087 | 5 | 0 | 4 |
| DBT | OCIAD1 | 0.749199 | 4 | 0 | 4 |
| DBT | UBXN2A | 0.74783 | 5 | 0 | 5 |
| DBT | UBQLN4 | 0.734953 | 7 | 0 | 6 |
| DBT | COQ7 | 0.732955 | 3 | 0 | 3 |
| DBT | FAM161B | 0.732344 | 7 | 0 | 5 |
For details and further investigation, click here
