| Full name: solute carrier family 22 member 3 | Alias Symbol: OCT3|EMT | ||
| Type: protein-coding gene | Cytoband: 6q25.3 | ||
| Entrez ID: 6581 | HGNC ID: HGNC:10967 | Ensembl Gene: ENSG00000146477 | OMIM ID: 604842 |
| Drug and gene relationship at DGIdb | |||
SLC22A3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05231 | Choline metabolism in cancer |
Expression of SLC22A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC22A3 | 6581 | 242578_x_at | 0.1643 | 0.8489 | |
| GSE20347 | SLC22A3 | 6581 | 205421_at | -0.7160 | 0.0128 | |
| GSE23400 | SLC22A3 | 6581 | 205421_at | 0.0153 | 0.7988 | |
| GSE26886 | SLC22A3 | 6581 | 242578_x_at | 0.1738 | 0.4678 | |
| GSE29001 | SLC22A3 | 6581 | 205421_at | -0.4554 | 0.4861 | |
| GSE38129 | SLC22A3 | 6581 | 205421_at | -1.0565 | 0.0001 | |
| GSE45670 | SLC22A3 | 6581 | 242578_x_at | 0.1774 | 0.2210 | |
| GSE63941 | SLC22A3 | 6581 | 242578_x_at | -0.2735 | 0.2685 | |
| GSE77861 | SLC22A3 | 6581 | 242578_x_at | 0.5761 | 0.1426 | |
| GSE97050 | SLC22A3 | 6581 | A_32_P309404 | 0.2166 | 0.6064 | |
| SRP007169 | SLC22A3 | 6581 | RNAseq | -2.5872 | 0.0000 | |
| SRP064894 | SLC22A3 | 6581 | RNAseq | -0.4735 | 0.1956 | |
| SRP133303 | SLC22A3 | 6581 | RNAseq | -0.7402 | 0.1157 | |
| SRP159526 | SLC22A3 | 6581 | RNAseq | -1.1472 | 0.0178 | |
| SRP193095 | SLC22A3 | 6581 | RNAseq | 0.0504 | 0.8682 | |
| SRP219564 | SLC22A3 | 6581 | RNAseq | -0.5098 | 0.1490 | |
| TCGA | SLC22A3 | 6581 | RNAseq | -0.4528 | 0.0948 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SLC22A3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SLC22A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC22A3 | 6581 | 1 | 5 | 24 | |
| GSE20123 | SLC22A3 | 6581 | 1 | 4 | 25 | |
| GSE43470 | SLC22A3 | 6581 | 4 | 0 | 39 | |
| GSE46452 | SLC22A3 | 6581 | 3 | 10 | 46 | |
| GSE47630 | SLC22A3 | 6581 | 9 | 4 | 27 | |
| GSE54993 | SLC22A3 | 6581 | 4 | 4 | 62 | |
| GSE54994 | SLC22A3 | 6581 | 8 | 9 | 36 | |
| GSE60625 | SLC22A3 | 6581 | 0 | 1 | 10 | |
| GSE74703 | SLC22A3 | 6581 | 4 | 0 | 32 | |
| GSE74704 | SLC22A3 | 6581 | 0 | 2 | 18 | |
| TCGA | SLC22A3 | 6581 | 13 | 22 | 61 |
Total number of gains: 47; Total number of losses: 61; Total Number of normals: 380.
Somatic mutations of SLC22A3:
Generating mutation plots.
Highly correlated genes for SLC22A3:
Showing top 20/69 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC22A3 | NLN | 0.920411 | 5 | 0 | 5 |
| SLC22A3 | CCDC152 | 0.913865 | 5 | 0 | 5 |
| SLC22A3 | PGF | 0.908673 | 5 | 0 | 5 |
| SLC22A3 | FBXW12 | 0.906518 | 5 | 0 | 5 |
| SLC22A3 | SLC35E1 | 0.896065 | 5 | 0 | 5 |
| SLC22A3 | DBT | 0.891548 | 4 | 0 | 4 |
| SLC22A3 | ALMS1 | 0.890993 | 3 | 0 | 3 |
| SLC22A3 | DDX59 | 0.887838 | 4 | 0 | 4 |
| SLC22A3 | HAUS2 | 0.887281 | 4 | 0 | 4 |
| SLC22A3 | C9orf64 | 0.86907 | 5 | 0 | 5 |
| SLC22A3 | MZT2B | 0.868765 | 5 | 0 | 5 |
| SLC22A3 | ZC3H7B | 0.864226 | 3 | 0 | 3 |
| SLC22A3 | DIP2A | 0.856072 | 5 | 0 | 5 |
| SLC22A3 | GTF2H3 | 0.855453 | 4 | 0 | 4 |
| SLC22A3 | ZNF721 | 0.849135 | 5 | 0 | 5 |
| SLC22A3 | CMBL | 0.847473 | 5 | 0 | 5 |
| SLC22A3 | ZNF611 | 0.816413 | 5 | 0 | 5 |
| SLC22A3 | FAM161B | 0.809091 | 5 | 0 | 5 |
| SLC22A3 | FUT8-AS1 | 0.804936 | 4 | 0 | 4 |
| SLC22A3 | UBXN2A | 0.802659 | 4 | 0 | 4 |
For details and further investigation, click here
