| Full name: membrane associated guanylate kinase, WW and PDZ domain containing 1 | Alias Symbol: BAP1|MAGI-1|TNRC19|AIP3|WWP3 | ||
| Type: protein-coding gene | Cytoband: 3p14.1 | ||
| Entrez ID: 9223 | HGNC ID: HGNC:946 | Ensembl Gene: ENSG00000151276 | OMIM ID: 602625 |
| Drug and gene relationship at DGIdb | |||
MAGI1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04530 | Tight junction |
Expression of MAGI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAGI1 | 9223 | 225465_at | -0.4732 | 0.1373 | |
| GSE20347 | MAGI1 | 9223 | 215372_x_at | 0.2155 | 0.1167 | |
| GSE23400 | MAGI1 | 9223 | 222372_at | -0.1776 | 0.0007 | |
| GSE26886 | MAGI1 | 9223 | 225465_at | -0.6095 | 0.0007 | |
| GSE29001 | MAGI1 | 9223 | 206144_at | -0.9562 | 0.0043 | |
| GSE38129 | MAGI1 | 9223 | 215372_x_at | 0.0293 | 0.8414 | |
| GSE45670 | MAGI1 | 9223 | 225465_at | -0.3089 | 0.0490 | |
| GSE53622 | MAGI1 | 9223 | 124928 | -1.3420 | 0.0000 | |
| GSE53624 | MAGI1 | 9223 | 124928 | -1.5761 | 0.0000 | |
| GSE63941 | MAGI1 | 9223 | 225465_at | -2.4870 | 0.0001 | |
| GSE77861 | MAGI1 | 9223 | 215372_x_at | 0.0410 | 0.8705 | |
| GSE97050 | MAGI1 | 9223 | A_24_P75220 | -1.0816 | 0.0691 | |
| SRP007169 | MAGI1 | 9223 | RNAseq | -0.2316 | 0.6486 | |
| SRP008496 | MAGI1 | 9223 | RNAseq | -0.2659 | 0.3975 | |
| SRP064894 | MAGI1 | 9223 | RNAseq | -1.3081 | 0.0000 | |
| SRP133303 | MAGI1 | 9223 | RNAseq | -1.1085 | 0.0000 | |
| SRP159526 | MAGI1 | 9223 | RNAseq | -0.9180 | 0.0012 | |
| SRP193095 | MAGI1 | 9223 | RNAseq | -0.9593 | 0.0000 | |
| SRP219564 | MAGI1 | 9223 | RNAseq | -1.3795 | 0.0010 | |
| TCGA | MAGI1 | 9223 | RNAseq | -0.7569 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by MAGI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAGI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAGI1 | 9223 | 1 | 17 | 12 | |
| GSE20123 | MAGI1 | 9223 | 1 | 17 | 12 | |
| GSE43470 | MAGI1 | 9223 | 0 | 20 | 23 | |
| GSE46452 | MAGI1 | 9223 | 2 | 17 | 40 | |
| GSE47630 | MAGI1 | 9223 | 1 | 24 | 15 | |
| GSE54993 | MAGI1 | 9223 | 5 | 2 | 63 | |
| GSE54994 | MAGI1 | 9223 | 1 | 33 | 19 | |
| GSE60625 | MAGI1 | 9223 | 3 | 1 | 7 | |
| GSE74703 | MAGI1 | 9223 | 0 | 16 | 20 | |
| GSE74704 | MAGI1 | 9223 | 0 | 12 | 8 | |
| TCGA | MAGI1 | 9223 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of MAGI1:
Generating mutation plots.
Highly correlated genes for MAGI1:
Showing top 20/843 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAGI1 | KLHL24 | 0.837324 | 4 | 0 | 4 |
| MAGI1 | USP34 | 0.836922 | 4 | 0 | 4 |
| MAGI1 | ZNF25 | 0.813293 | 3 | 0 | 3 |
| MAGI1 | SEMA6A | 0.802058 | 3 | 0 | 3 |
| MAGI1 | DCLRE1C | 0.790483 | 4 | 0 | 4 |
| MAGI1 | DBT | 0.784655 | 5 | 0 | 5 |
| MAGI1 | ZNF547 | 0.760465 | 3 | 0 | 3 |
| MAGI1 | IFFO1 | 0.759945 | 3 | 0 | 3 |
| MAGI1 | CA13 | 0.75634 | 3 | 0 | 3 |
| MAGI1 | SH3BGRL2 | 0.751465 | 6 | 0 | 6 |
| MAGI1 | CTTNBP2 | 0.747463 | 6 | 0 | 6 |
| MAGI1 | UACA | 0.741613 | 3 | 0 | 3 |
| MAGI1 | SLC10A5 | 0.739949 | 3 | 0 | 3 |
| MAGI1 | FBXW12 | 0.737939 | 4 | 0 | 3 |
| MAGI1 | VSIG2 | 0.73624 | 5 | 0 | 5 |
| MAGI1 | NEK1 | 0.735499 | 3 | 0 | 3 |
| MAGI1 | PAQR8 | 0.7354 | 6 | 0 | 6 |
| MAGI1 | LCA5 | 0.725344 | 3 | 0 | 3 |
| MAGI1 | CLEC3B | 0.724915 | 3 | 0 | 3 |
| MAGI1 | CGNL1 | 0.720735 | 6 | 0 | 6 |
For details and further investigation, click here
