| Full name: DEAD-box helicase 59 | Alias Symbol: DKFZP564B1023|ZNHIT5 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 83479 | HGNC ID: HGNC:25360 | Ensembl Gene: ENSG00000118197 | OMIM ID: 615464 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX59:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX59 | 83479 | 223662_x_at | 0.2296 | 0.6528 | |
| GSE26886 | DDX59 | 83479 | 223662_x_at | 0.2951 | 0.0488 | |
| GSE45670 | DDX59 | 83479 | 223662_x_at | 0.1966 | 0.0551 | |
| GSE53622 | DDX59 | 83479 | 127402 | 0.1246 | 0.0224 | |
| GSE53624 | DDX59 | 83479 | 127402 | 0.0490 | 0.4711 | |
| GSE63941 | DDX59 | 83479 | 228385_at | 0.1154 | 0.8300 | |
| GSE77861 | DDX59 | 83479 | 223662_x_at | 0.6721 | 0.0567 | |
| GSE97050 | DDX59 | 83479 | A_24_P156886 | -0.0285 | 0.9010 | |
| SRP007169 | DDX59 | 83479 | RNAseq | -0.6110 | 0.0780 | |
| SRP008496 | DDX59 | 83479 | RNAseq | -0.4922 | 0.1288 | |
| SRP064894 | DDX59 | 83479 | RNAseq | -0.3199 | 0.0612 | |
| SRP133303 | DDX59 | 83479 | RNAseq | -0.1117 | 0.4568 | |
| SRP159526 | DDX59 | 83479 | RNAseq | 0.2137 | 0.4921 | |
| SRP193095 | DDX59 | 83479 | RNAseq | -0.2810 | 0.0112 | |
| SRP219564 | DDX59 | 83479 | RNAseq | -0.0468 | 0.8624 | |
| TCGA | DDX59 | 83479 | RNAseq | 0.0933 | 0.1255 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDX59 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX59:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX59 | 83479 | 11 | 0 | 19 | |
| GSE20123 | DDX59 | 83479 | 11 | 0 | 19 | |
| GSE43470 | DDX59 | 83479 | 6 | 0 | 37 | |
| GSE46452 | DDX59 | 83479 | 3 | 1 | 55 | |
| GSE47630 | DDX59 | 83479 | 14 | 0 | 26 | |
| GSE54993 | DDX59 | 83479 | 0 | 6 | 64 | |
| GSE54994 | DDX59 | 83479 | 13 | 0 | 40 | |
| GSE60625 | DDX59 | 83479 | 0 | 0 | 11 | |
| GSE74703 | DDX59 | 83479 | 6 | 0 | 30 | |
| GSE74704 | DDX59 | 83479 | 5 | 0 | 15 | |
| TCGA | DDX59 | 83479 | 43 | 4 | 49 |
Total number of gains: 112; Total number of losses: 11; Total Number of normals: 365.
Somatic mutations of DDX59:
Generating mutation plots.
Highly correlated genes for DDX59:
Showing top 20/361 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX59 | ZNF721 | 0.951944 | 5 | 0 | 5 |
| DDX59 | ALMS1 | 0.945026 | 4 | 0 | 4 |
| DDX59 | PRR11 | 0.942981 | 4 | 0 | 4 |
| DDX59 | CMBL | 0.938599 | 4 | 0 | 4 |
| DDX59 | MZT2B | 0.921524 | 5 | 0 | 5 |
| DDX59 | DIP2A | 0.891566 | 5 | 0 | 5 |
| DDX59 | ZNF611 | 0.888872 | 4 | 0 | 4 |
| DDX59 | SLC22A3 | 0.887838 | 4 | 0 | 4 |
| DDX59 | ZC3H7B | 0.873785 | 4 | 0 | 4 |
| DDX59 | NLN | 0.867074 | 5 | 0 | 5 |
| DDX59 | PTPN4 | 0.864374 | 3 | 0 | 3 |
| DDX59 | FUT8-AS1 | 0.860103 | 4 | 0 | 4 |
| DDX59 | DLGAP4 | 0.849112 | 5 | 0 | 5 |
| DDX59 | LCAT | 0.848076 | 3 | 0 | 3 |
| DDX59 | ORAI2 | 0.846823 | 4 | 0 | 4 |
| DDX59 | ANKRD10-IT1 | 0.842964 | 4 | 0 | 4 |
| DDX59 | POLR1B | 0.82914 | 3 | 0 | 3 |
| DDX59 | TNRC6C-AS1 | 0.828317 | 4 | 0 | 4 |
| DDX59 | DBT | 0.82179 | 5 | 0 | 5 |
| DDX59 | FAM161B | 0.821161 | 5 | 0 | 5 |
For details and further investigation, click here
