| Full name: DENN domain containing 3 | Alias Symbol: KIAA0870 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 22898 | HGNC ID: HGNC:29134 | Ensembl Gene: ENSG00000105339 | OMIM ID: 617503 |
| Drug and gene relationship at DGIdb | |||
Expression of DENND3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND3 | 22898 | 212975_at | 0.3621 | 0.6175 | |
| GSE20347 | DENND3 | 22898 | 212975_at | 0.4036 | 0.0021 | |
| GSE23400 | DENND3 | 22898 | 212975_at | 0.1617 | 0.0046 | |
| GSE26886 | DENND3 | 22898 | 212975_at | 0.4289 | 0.0291 | |
| GSE29001 | DENND3 | 22898 | 212975_at | 0.3915 | 0.0642 | |
| GSE38129 | DENND3 | 22898 | 212975_at | 0.0658 | 0.6967 | |
| GSE45670 | DENND3 | 22898 | 212975_at | 0.0271 | 0.9092 | |
| GSE53622 | DENND3 | 22898 | 57276 | 0.1714 | 0.0450 | |
| GSE53624 | DENND3 | 22898 | 57276 | 0.3894 | 0.0000 | |
| GSE63941 | DENND3 | 22898 | 212975_at | 0.0771 | 0.8956 | |
| GSE77861 | DENND3 | 22898 | 212975_at | 0.2446 | 0.0388 | |
| GSE97050 | DENND3 | 22898 | A_33_P3321136 | 0.4168 | 0.1628 | |
| SRP007169 | DENND3 | 22898 | RNAseq | 2.5509 | 0.0001 | |
| SRP064894 | DENND3 | 22898 | RNAseq | 0.5474 | 0.0139 | |
| SRP133303 | DENND3 | 22898 | RNAseq | 0.4595 | 0.0570 | |
| SRP159526 | DENND3 | 22898 | RNAseq | -0.0728 | 0.8801 | |
| SRP193095 | DENND3 | 22898 | RNAseq | 1.0812 | 0.0001 | |
| SRP219564 | DENND3 | 22898 | RNAseq | 1.1422 | 0.0313 | |
| TCGA | DENND3 | 22898 | RNAseq | -0.2770 | 0.0031 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DENND3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND3 | 22898 | 17 | 0 | 13 | |
| GSE20123 | DENND3 | 22898 | 16 | 0 | 14 | |
| GSE43470 | DENND3 | 22898 | 21 | 2 | 20 | |
| GSE46452 | DENND3 | 22898 | 27 | 0 | 32 | |
| GSE47630 | DENND3 | 22898 | 24 | 0 | 16 | |
| GSE54993 | DENND3 | 22898 | 0 | 26 | 44 | |
| GSE54994 | DENND3 | 22898 | 39 | 1 | 13 | |
| GSE60625 | DENND3 | 22898 | 3 | 4 | 4 | |
| GSE74703 | DENND3 | 22898 | 19 | 1 | 16 | |
| GSE74704 | DENND3 | 22898 | 10 | 0 | 10 | |
| TCGA | DENND3 | 22898 | 65 | 2 | 29 |
Total number of gains: 241; Total number of losses: 36; Total Number of normals: 211.
Somatic mutations of DENND3:
Generating mutation plots.
Highly correlated genes for DENND3:
Showing top 20/835 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND3 | ACIN1 | 0.824336 | 3 | 0 | 3 |
| DENND3 | BTN3A2 | 0.804103 | 3 | 0 | 3 |
| DENND3 | NEU1 | 0.778532 | 3 | 0 | 3 |
| DENND3 | PLD3 | 0.775121 | 5 | 0 | 5 |
| DENND3 | KRTAP12-2 | 0.759518 | 3 | 0 | 3 |
| DENND3 | MLF2 | 0.748177 | 3 | 0 | 3 |
| DENND3 | ZBED1 | 0.745253 | 4 | 0 | 4 |
| DENND3 | ZNF248 | 0.740095 | 3 | 0 | 3 |
| DENND3 | CAPN12 | 0.736451 | 3 | 0 | 3 |
| DENND3 | CDH24 | 0.734016 | 3 | 0 | 3 |
| DENND3 | SLC26A5 | 0.733975 | 3 | 0 | 3 |
| DENND3 | WDR81 | 0.733302 | 4 | 0 | 4 |
| DENND3 | OR2T33 | 0.732922 | 3 | 0 | 3 |
| DENND3 | ALG11 | 0.727859 | 3 | 0 | 3 |
| DENND3 | SLC36A1 | 0.721106 | 3 | 0 | 3 |
| DENND3 | ATRN | 0.716307 | 3 | 0 | 3 |
| DENND3 | SPHK2 | 0.711977 | 3 | 0 | 3 |
| DENND3 | BTBD2 | 0.711677 | 3 | 0 | 3 |
| DENND3 | PPRC1 | 0.707437 | 3 | 0 | 3 |
| DENND3 | ARMC6 | 0.703649 | 3 | 0 | 3 |
For details and further investigation, click here
