| Full name: PPARG related coactivator 1 | Alias Symbol: PRC|KIAA0595|MGC74642 | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 23082 | HGNC ID: HGNC:30025 | Ensembl Gene: ENSG00000148840 | OMIM ID: 617462 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PPRC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPRC1 | 23082 | 203737_s_at | 0.7222 | 0.2548 | |
| GSE20347 | PPRC1 | 23082 | 203737_s_at | 0.3019 | 0.0982 | |
| GSE23400 | PPRC1 | 23082 | 203737_s_at | 0.4638 | 0.0000 | |
| GSE26886 | PPRC1 | 23082 | 203737_s_at | 1.3836 | 0.0000 | |
| GSE29001 | PPRC1 | 23082 | 203737_s_at | 0.3652 | 0.2308 | |
| GSE38129 | PPRC1 | 23082 | 203737_s_at | 0.5389 | 0.0001 | |
| GSE45670 | PPRC1 | 23082 | 203737_s_at | 0.1676 | 0.4109 | |
| GSE53622 | PPRC1 | 23082 | 7677 | 0.4128 | 0.0000 | |
| GSE53624 | PPRC1 | 23082 | 7677 | 0.6563 | 0.0000 | |
| GSE63941 | PPRC1 | 23082 | 203737_s_at | -0.3839 | 0.2706 | |
| GSE77861 | PPRC1 | 23082 | 203737_s_at | 0.4940 | 0.0072 | |
| GSE97050 | PPRC1 | 23082 | A_23_P127079 | 0.6159 | 0.1308 | |
| SRP007169 | PPRC1 | 23082 | RNAseq | 1.0178 | 0.0100 | |
| SRP008496 | PPRC1 | 23082 | RNAseq | 1.1362 | 0.0004 | |
| SRP064894 | PPRC1 | 23082 | RNAseq | -0.2428 | 0.3196 | |
| SRP133303 | PPRC1 | 23082 | RNAseq | 0.3492 | 0.0911 | |
| SRP159526 | PPRC1 | 23082 | RNAseq | 0.0273 | 0.9430 | |
| SRP193095 | PPRC1 | 23082 | RNAseq | 0.6795 | 0.0000 | |
| SRP219564 | PPRC1 | 23082 | RNAseq | 0.2970 | 0.4513 | |
| TCGA | PPRC1 | 23082 | RNAseq | 0.0271 | 0.5518 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PPRC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPRC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPRC1 | 23082 | 2 | 9 | 19 | |
| GSE20123 | PPRC1 | 23082 | 2 | 8 | 20 | |
| GSE43470 | PPRC1 | 23082 | 0 | 8 | 35 | |
| GSE46452 | PPRC1 | 23082 | 0 | 11 | 48 | |
| GSE47630 | PPRC1 | 23082 | 2 | 14 | 24 | |
| GSE54993 | PPRC1 | 23082 | 8 | 0 | 62 | |
| GSE54994 | PPRC1 | 23082 | 1 | 12 | 40 | |
| GSE60625 | PPRC1 | 23082 | 0 | 0 | 11 | |
| GSE74703 | PPRC1 | 23082 | 0 | 5 | 31 | |
| GSE74704 | PPRC1 | 23082 | 1 | 4 | 15 | |
| TCGA | PPRC1 | 23082 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 100; Total Number of normals: 367.
Somatic mutations of PPRC1:
Generating mutation plots.
Highly correlated genes for PPRC1:
Showing top 20/1335 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPRC1 | ZNF574 | 0.828815 | 3 | 0 | 3 |
| PPRC1 | SEMA3C | 0.806986 | 3 | 0 | 3 |
| PPRC1 | ZSCAN21 | 0.787051 | 3 | 0 | 3 |
| PPRC1 | OSR2 | 0.76947 | 3 | 0 | 3 |
| PPRC1 | RAVER1 | 0.763453 | 4 | 0 | 4 |
| PPRC1 | PKIG | 0.759688 | 3 | 0 | 3 |
| PPRC1 | ATF2 | 0.753038 | 3 | 0 | 3 |
| PPRC1 | RILPL2 | 0.752218 | 3 | 0 | 3 |
| PPRC1 | ZBTB37 | 0.747783 | 3 | 0 | 3 |
| PPRC1 | CYHR1 | 0.745137 | 3 | 0 | 3 |
| PPRC1 | PRR12 | 0.739779 | 3 | 0 | 3 |
| PPRC1 | HIBADH | 0.739317 | 4 | 0 | 3 |
| PPRC1 | PPP1R16A | 0.737073 | 3 | 0 | 3 |
| PPRC1 | SEL1L3 | 0.736189 | 3 | 0 | 3 |
| PPRC1 | DMTF1 | 0.734826 | 4 | 0 | 4 |
| PPRC1 | UBB | 0.730452 | 3 | 0 | 3 |
| PPRC1 | TIGD1 | 0.728929 | 4 | 0 | 4 |
| PPRC1 | ZCCHC3 | 0.727492 | 3 | 0 | 3 |
| PPRC1 | PHRF1 | 0.725733 | 3 | 0 | 3 |
| PPRC1 | TMEM63B | 0.725073 | 3 | 0 | 3 |
For details and further investigation, click here
