MLF2

 

Full name: myeloid leukemia factor 2 Alias Symbol: NTN4
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 8079 HGNC ID: HGNC:7126 Ensembl Gene: ENSG00000089693 OMIM ID: 601401
Drug and gene relationship at DGIdb

 

Expression of MLF2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MLF2 8079 200948_at 0.3793 0.3734
GSE20347 MLF2 8079 200948_at 0.3353 0.0499
GSE23400 MLF2 8079 200948_at 0.4951 0.0000
GSE26886 MLF2 8079 200948_at -0.0797 0.8243
GSE29001 MLF2 8079 200948_at 0.4982 0.3050
GSE38129 MLF2 8079 200948_at 0.2515 0.0546
GSE45670 MLF2 8079 200948_at 0.4532 0.0354
GSE53622 MLF2 8079 5507 0.5539 0.0000
GSE53624 MLF2 8079 5507 0.5235 0.0000
GSE63941 MLF2 8079 200948_at 2.1223 0.0003
GSE77861 MLF2 8079 200948_at 0.3960 0.1049
GSE97050 MLF2 8079 A_23_P13873 0.3148 0.2813
SRP007169 MLF2 8079 RNAseq -0.1869 0.5709
SRP008496 MLF2 8079 RNAseq -0.0284 0.8873
SRP064894 MLF2 8079 RNAseq 0.4407 0.0614
SRP133303 MLF2 8079 RNAseq 0.5033 0.0368
SRP159526 MLF2 8079 RNAseq 0.5420 0.0071
SRP193095 MLF2 8079 RNAseq 0.3820 0.0025
SRP219564 MLF2 8079 RNAseq 0.1968 0.4741
TCGA MLF2 8079 RNAseq 0.1657 0.0001

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by MLF2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MLF2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MLF2 8079 9 3 18
GSE20123 MLF2 8079 9 3 18
GSE43470 MLF2 8079 8 3 32
GSE46452 MLF2 8079 10 1 48
GSE47630 MLF2 8079 12 2 26
GSE54993 MLF2 8079 1 10 59
GSE54994 MLF2 8079 10 2 41
GSE60625 MLF2 8079 0 1 10
GSE74703 MLF2 8079 7 2 27
GSE74704 MLF2 8079 5 2 13
TCGA MLF2 8079 40 6 50

Total number of gains: 111; Total number of losses: 35; Total Number of normals: 342.  

 

Somatic mutations of MLF2:

 

Generating mutation plots.

 

Highly correlated genes for MLF2:

 

Showing top 20/1128 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MLF2DENND30.748177303
MLF2NOP20.74469410010
MLF2PHB20.74423613013
MLF2RAB11B0.742952403
MLF2SCAF10.736826303
MLF2MRPL380.722917504
MLF2ZNF6680.719693303
MLF2MRPL510.717948807
MLF2GAPDH0.71298510010
MLF2SPNS10.708348303
MLF2FKBP40.70707612012
MLF2ZNF3840.70403510010
MLF2CSNK1D0.700891403
MLF2PRELID10.699708404
MLF2COPS7A0.69550812010
MLF2MRPL40.693812908
MLF2STRAP0.69344910010
MLF2USP50.69069112012
MLF2SPRYD40.6902303
MLF2PTCD10.686121303

For details and further investigation, click here