| Full name: phospholipase D family member 3 | Alias Symbol: HU-K4 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 23646 | HGNC ID: HGNC:17158 | Ensembl Gene: ENSG00000105223 | OMIM ID: 615698 |
| Drug and gene relationship at DGIdb | |||
Expression of PLD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLD3 | 23646 | 201050_at | 0.3230 | 0.5556 | |
| GSE20347 | PLD3 | 23646 | 201050_at | 0.6273 | 0.0014 | |
| GSE23400 | PLD3 | 23646 | 201050_at | 0.4488 | 0.0000 | |
| GSE26886 | PLD3 | 23646 | 201050_at | 0.5860 | 0.0600 | |
| GSE29001 | PLD3 | 23646 | 201050_at | 0.5126 | 0.0285 | |
| GSE38129 | PLD3 | 23646 | 201050_at | 0.6737 | 0.0005 | |
| GSE45670 | PLD3 | 23646 | 201050_at | 0.2302 | 0.2111 | |
| GSE53622 | PLD3 | 23646 | 63968 | 0.7332 | 0.0000 | |
| GSE53624 | PLD3 | 23646 | 63968 | 0.9012 | 0.0000 | |
| GSE63941 | PLD3 | 23646 | 201050_at | 0.9375 | 0.2067 | |
| GSE77861 | PLD3 | 23646 | 201050_at | 1.3536 | 0.0032 | |
| GSE97050 | PLD3 | 23646 | A_23_P27515 | 0.3363 | 0.2239 | |
| SRP007169 | PLD3 | 23646 | RNAseq | 0.9598 | 0.0130 | |
| SRP008496 | PLD3 | 23646 | RNAseq | 0.9025 | 0.0133 | |
| SRP064894 | PLD3 | 23646 | RNAseq | 1.1456 | 0.0000 | |
| SRP133303 | PLD3 | 23646 | RNAseq | 0.8065 | 0.0001 | |
| SRP159526 | PLD3 | 23646 | RNAseq | 1.0333 | 0.0003 | |
| SRP193095 | PLD3 | 23646 | RNAseq | 0.9514 | 0.0000 | |
| SRP219564 | PLD3 | 23646 | RNAseq | 0.9388 | 0.0634 | |
| TCGA | PLD3 | 23646 | RNAseq | 0.0257 | 0.6159 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PLD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLD3 | 23646 | 6 | 5 | 19 | |
| GSE20123 | PLD3 | 23646 | 6 | 4 | 20 | |
| GSE43470 | PLD3 | 23646 | 3 | 9 | 31 | |
| GSE46452 | PLD3 | 23646 | 48 | 1 | 10 | |
| GSE47630 | PLD3 | 23646 | 9 | 5 | 26 | |
| GSE54993 | PLD3 | 23646 | 17 | 3 | 50 | |
| GSE54994 | PLD3 | 23646 | 8 | 9 | 36 | |
| GSE60625 | PLD3 | 23646 | 9 | 0 | 2 | |
| GSE74703 | PLD3 | 23646 | 3 | 6 | 27 | |
| GSE74704 | PLD3 | 23646 | 6 | 2 | 12 | |
| TCGA | PLD3 | 23646 | 14 | 16 | 66 |
Total number of gains: 129; Total number of losses: 60; Total Number of normals: 299.
Somatic mutations of PLD3:
Generating mutation plots.
Highly correlated genes for PLD3:
Showing top 20/1222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLD3 | MED12 | 0.802682 | 3 | 0 | 3 |
| PLD3 | DENND3 | 0.775121 | 5 | 0 | 5 |
| PLD3 | PYCR2 | 0.759369 | 3 | 0 | 3 |
| PLD3 | RAB34 | 0.756064 | 3 | 0 | 3 |
| PLD3 | NONO | 0.751518 | 7 | 0 | 7 |
| PLD3 | PDIA5 | 0.744564 | 3 | 0 | 3 |
| PLD3 | PRPSAP2 | 0.73656 | 3 | 0 | 3 |
| PLD3 | AKR1B1 | 0.735523 | 4 | 0 | 4 |
| PLD3 | OR51E1 | 0.734134 | 3 | 0 | 3 |
| PLD3 | FREM2 | 0.718525 | 3 | 0 | 3 |
| PLD3 | RASAL3 | 0.712997 | 3 | 0 | 3 |
| PLD3 | FUCA2 | 0.709254 | 5 | 0 | 5 |
| PLD3 | SPON2 | 0.70195 | 3 | 0 | 3 |
| PLD3 | FADS1 | 0.701645 | 3 | 0 | 3 |
| PLD3 | ZNF496 | 0.701067 | 4 | 0 | 4 |
| PLD3 | GORAB | 0.696717 | 4 | 0 | 4 |
| PLD3 | AZIN2 | 0.695564 | 4 | 0 | 3 |
| PLD3 | GLT8D1 | 0.69496 | 3 | 0 | 3 |
| PLD3 | TTL | 0.690716 | 4 | 0 | 4 |
| PLD3 | SPI1 | 0.688108 | 5 | 0 | 4 |
For details and further investigation, click here
