| Full name: dual specificity tyrosine phosphorylation regulated kinase 1B | Alias Symbol: MIRK | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 9149 | HGNC ID: HGNC:3092 | Ensembl Gene: ENSG00000105204 | OMIM ID: 604556 |
| Drug and gene relationship at DGIdb | |||
Expression of DYRK1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYRK1B | 9149 | 217270_s_at | -0.0614 | 0.8587 | |
| GSE20347 | DYRK1B | 9149 | 217270_s_at | -0.0687 | 0.3195 | |
| GSE23400 | DYRK1B | 9149 | 204954_s_at | -0.0361 | 0.4116 | |
| GSE26886 | DYRK1B | 9149 | 204954_s_at | 0.4196 | 0.0046 | |
| GSE29001 | DYRK1B | 9149 | 204954_s_at | -0.0835 | 0.7524 | |
| GSE38129 | DYRK1B | 9149 | 204954_s_at | 0.0193 | 0.8621 | |
| GSE45670 | DYRK1B | 9149 | 204954_s_at | -0.0075 | 0.9530 | |
| GSE53622 | DYRK1B | 9149 | 10645 | -0.3135 | 0.0006 | |
| GSE53624 | DYRK1B | 9149 | 10645 | -0.3048 | 0.0001 | |
| GSE63941 | DYRK1B | 9149 | 204954_s_at | -0.2520 | 0.3861 | |
| GSE77861 | DYRK1B | 9149 | 217270_s_at | 0.0284 | 0.8530 | |
| GSE97050 | DYRK1B | 9149 | A_23_P90296 | -0.2155 | 0.3270 | |
| SRP007169 | DYRK1B | 9149 | RNAseq | -0.9598 | 0.0927 | |
| SRP064894 | DYRK1B | 9149 | RNAseq | -0.0063 | 0.9809 | |
| SRP133303 | DYRK1B | 9149 | RNAseq | -0.4986 | 0.0076 | |
| SRP159526 | DYRK1B | 9149 | RNAseq | 0.1142 | 0.6280 | |
| SRP193095 | DYRK1B | 9149 | RNAseq | 0.1369 | 0.3193 | |
| SRP219564 | DYRK1B | 9149 | RNAseq | -0.1480 | 0.6910 | |
| TCGA | DYRK1B | 9149 | RNAseq | -0.0725 | 0.4578 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DYRK1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYRK1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYRK1B | 9149 | 7 | 4 | 19 | |
| GSE20123 | DYRK1B | 9149 | 7 | 3 | 20 | |
| GSE43470 | DYRK1B | 9149 | 3 | 11 | 29 | |
| GSE46452 | DYRK1B | 9149 | 48 | 1 | 10 | |
| GSE47630 | DYRK1B | 9149 | 9 | 5 | 26 | |
| GSE54993 | DYRK1B | 9149 | 17 | 3 | 50 | |
| GSE54994 | DYRK1B | 9149 | 8 | 9 | 36 | |
| GSE60625 | DYRK1B | 9149 | 9 | 0 | 2 | |
| GSE74703 | DYRK1B | 9149 | 3 | 7 | 26 | |
| GSE74704 | DYRK1B | 9149 | 7 | 1 | 12 | |
| TCGA | DYRK1B | 9149 | 14 | 16 | 66 |
Total number of gains: 132; Total number of losses: 60; Total Number of normals: 296.
Somatic mutations of DYRK1B:
Generating mutation plots.
Highly correlated genes for DYRK1B:
Showing top 20/405 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYRK1B | ZNF157 | 0.792866 | 4 | 0 | 4 |
| DYRK1B | GDF7 | 0.789441 | 3 | 0 | 3 |
| DYRK1B | GRIK4 | 0.785892 | 3 | 0 | 3 |
| DYRK1B | RNF180 | 0.756833 | 3 | 0 | 3 |
| DYRK1B | ANKRD33 | 0.747512 | 3 | 0 | 3 |
| DYRK1B | TTLL9 | 0.745954 | 4 | 0 | 3 |
| DYRK1B | PRG3 | 0.7448 | 3 | 0 | 3 |
| DYRK1B | SUN5 | 0.744047 | 3 | 0 | 3 |
| DYRK1B | ZNF527 | 0.743994 | 4 | 0 | 4 |
| DYRK1B | STRC | 0.732128 | 3 | 0 | 3 |
| DYRK1B | ZNF497 | 0.732062 | 3 | 0 | 3 |
| DYRK1B | SALL3 | 0.726387 | 4 | 0 | 4 |
| DYRK1B | CPA5 | 0.72246 | 3 | 0 | 3 |
| DYRK1B | C1QL2 | 0.722174 | 3 | 0 | 3 |
| DYRK1B | YY2 | 0.709938 | 3 | 0 | 3 |
| DYRK1B | TTC12 | 0.709201 | 3 | 0 | 3 |
| DYRK1B | TSPAN11 | 0.705085 | 4 | 0 | 3 |
| DYRK1B | ZBTB45 | 0.699516 | 5 | 0 | 4 |
| DYRK1B | FTMT | 0.699353 | 3 | 0 | 3 |
| DYRK1B | DBX1 | 0.697959 | 3 | 0 | 3 |
For details and further investigation, click here
