| Full name: growth differentiation factor 7 | Alias Symbol: BMP12 | ||
| Type: protein-coding gene | Cytoband: 2p24.1 | ||
| Entrez ID: 151449 | HGNC ID: HGNC:4222 | Ensembl Gene: ENSG00000143869 | OMIM ID: 604651 |
| Drug and gene relationship at DGIdb | |||
GDF7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04360 | Axon guidance | |
| hsa04390 | Hippo signaling pathway |
Expression of GDF7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | GDF7 | 151449 | 11285 | -0.4284 | 0.0000 | |
| GSE53624 | GDF7 | 151449 | 11285 | -0.1798 | 0.0655 | |
| GSE97050 | GDF7 | 151449 | A_33_P3406240 | -0.4780 | 0.1506 | |
| SRP007169 | GDF7 | 151449 | RNAseq | -4.1109 | 0.0000 | |
| SRP064894 | GDF7 | 151449 | RNAseq | -2.3242 | 0.0000 | |
| SRP133303 | GDF7 | 151449 | RNAseq | -1.9237 | 0.0000 | |
| SRP159526 | GDF7 | 151449 | RNAseq | -0.3558 | 0.6577 | |
| SRP193095 | GDF7 | 151449 | RNAseq | -1.4319 | 0.0000 | |
| TCGA | GDF7 | 151449 | RNAseq | -2.1138 | 0.0071 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by GDF7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GDF7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GDF7 | 151449 | 9 | 2 | 19 | |
| GSE20123 | GDF7 | 151449 | 9 | 2 | 19 | |
| GSE43470 | GDF7 | 151449 | 2 | 0 | 41 | |
| GSE46452 | GDF7 | 151449 | 3 | 4 | 52 | |
| GSE47630 | GDF7 | 151449 | 7 | 0 | 33 | |
| GSE54993 | GDF7 | 151449 | 0 | 7 | 63 | |
| GSE54994 | GDF7 | 151449 | 11 | 0 | 42 | |
| GSE60625 | GDF7 | 151449 | 0 | 3 | 8 | |
| GSE74703 | GDF7 | 151449 | 2 | 0 | 34 | |
| GSE74704 | GDF7 | 151449 | 8 | 2 | 10 | |
| TCGA | GDF7 | 151449 | 35 | 2 | 59 |
Total number of gains: 86; Total number of losses: 22; Total Number of normals: 380.
Somatic mutations of GDF7:
Generating mutation plots.
Highly correlated genes for GDF7:
Showing top 20/139 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GDF7 | SLC22A7 | 0.879252 | 3 | 0 | 3 |
| GDF7 | SAMD4A | 0.872952 | 3 | 0 | 3 |
| GDF7 | PRG3 | 0.849559 | 3 | 0 | 3 |
| GDF7 | SCARA5 | 0.842958 | 3 | 0 | 3 |
| GDF7 | KCNJ13 | 0.831818 | 3 | 0 | 3 |
| GDF7 | PKD2L1 | 0.82886 | 3 | 0 | 3 |
| GDF7 | TTC21A | 0.822318 | 3 | 0 | 3 |
| GDF7 | KRT77 | 0.819146 | 3 | 0 | 3 |
| GDF7 | C8G | 0.817408 | 3 | 0 | 3 |
| GDF7 | SALL3 | 0.817152 | 3 | 0 | 3 |
| GDF7 | ZNF326 | 0.815425 | 3 | 0 | 3 |
| GDF7 | FXYD2 | 0.814865 | 3 | 0 | 3 |
| GDF7 | KRTAP6-1 | 0.812052 | 3 | 0 | 3 |
| GDF7 | PAX6 | 0.808975 | 3 | 0 | 3 |
| GDF7 | PAX2 | 0.808411 | 3 | 0 | 3 |
| GDF7 | ZC3H10 | 0.807832 | 3 | 0 | 3 |
| GDF7 | FZD9 | 0.807789 | 3 | 0 | 3 |
| GDF7 | RNF180 | 0.806403 | 3 | 0 | 3 |
| GDF7 | SRPK3 | 0.806397 | 3 | 0 | 3 |
| GDF7 | YY2 | 0.803517 | 3 | 0 | 3 |
For details and further investigation, click here
