| Full name: erythropoietin receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 2057 | HGNC ID: HGNC:3416 | Ensembl Gene: ENSG00000187266 | OMIM ID: 133171 |
| Drug and gene relationship at DGIdb | |||
EPOR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of EPOR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPOR | 2057 | 396_f_at | -0.1422 | 0.6954 | |
| GSE20347 | EPOR | 2057 | 396_f_at | 0.0479 | 0.7849 | |
| GSE23400 | EPOR | 2057 | 396_f_at | -0.0951 | 0.0374 | |
| GSE26886 | EPOR | 2057 | 396_f_at | -0.3041 | 0.0729 | |
| GSE29001 | EPOR | 2057 | 396_f_at | -0.5278 | 0.0274 | |
| GSE38129 | EPOR | 2057 | 396_f_at | -0.1683 | 0.4023 | |
| GSE45670 | EPOR | 2057 | 396_f_at | -0.1775 | 0.2077 | |
| GSE53622 | EPOR | 2057 | 917 | 0.6352 | 0.0000 | |
| GSE53624 | EPOR | 2057 | 61887 | -0.2338 | 0.0033 | |
| GSE63941 | EPOR | 2057 | 396_f_at | 0.8915 | 0.0001 | |
| GSE77861 | EPOR | 2057 | 396_f_at | -0.1561 | 0.2247 | |
| GSE97050 | EPOR | 2057 | A_23_P367899 | 0.6140 | 0.1313 | |
| SRP007169 | EPOR | 2057 | RNAseq | 0.0029 | 0.9967 | |
| SRP064894 | EPOR | 2057 | RNAseq | 0.7848 | 0.0021 | |
| SRP133303 | EPOR | 2057 | RNAseq | 0.2352 | 0.4113 | |
| SRP159526 | EPOR | 2057 | RNAseq | 0.5899 | 0.2383 | |
| SRP193095 | EPOR | 2057 | RNAseq | 0.5639 | 0.0282 | |
| SRP219564 | EPOR | 2057 | RNAseq | 1.0974 | 0.0019 | |
| TCGA | EPOR | 2057 | RNAseq | -0.5526 | 0.0010 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EPOR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPOR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPOR | 2057 | 4 | 2 | 24 | |
| GSE20123 | EPOR | 2057 | 3 | 1 | 26 | |
| GSE43470 | EPOR | 2057 | 2 | 6 | 35 | |
| GSE46452 | EPOR | 2057 | 47 | 1 | 11 | |
| GSE47630 | EPOR | 2057 | 4 | 7 | 29 | |
| GSE54993 | EPOR | 2057 | 16 | 3 | 51 | |
| GSE54994 | EPOR | 2057 | 6 | 13 | 34 | |
| GSE60625 | EPOR | 2057 | 9 | 0 | 2 | |
| GSE74703 | EPOR | 2057 | 2 | 4 | 30 | |
| GSE74704 | EPOR | 2057 | 0 | 1 | 19 | |
| TCGA | EPOR | 2057 | 16 | 12 | 68 |
Total number of gains: 109; Total number of losses: 50; Total Number of normals: 329.
Somatic mutations of EPOR:
Generating mutation plots.
Highly correlated genes for EPOR:
Showing top 20/894 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPOR | G6PC2 | 0.763666 | 6 | 0 | 6 |
| EPOR | SLC5A7 | 0.751188 | 6 | 0 | 6 |
| EPOR | OR10H3 | 0.720199 | 7 | 0 | 6 |
| EPOR | IFNA4 | 0.719742 | 4 | 0 | 4 |
| EPOR | KRT38 | 0.71893 | 4 | 0 | 4 |
| EPOR | ART1 | 0.718748 | 6 | 0 | 6 |
| EPOR | C10orf90 | 0.717075 | 3 | 0 | 3 |
| EPOR | WFDC9 | 0.716108 | 3 | 0 | 3 |
| EPOR | ATXN2L | 0.710635 | 6 | 0 | 5 |
| EPOR | PRR34 | 0.709538 | 5 | 0 | 5 |
| EPOR | RNF185-AS1 | 0.706403 | 5 | 0 | 5 |
| EPOR | IL1RAPL2 | 0.705755 | 7 | 0 | 6 |
| EPOR | RRH | 0.704836 | 4 | 0 | 4 |
| EPOR | MAP3K19 | 0.703918 | 7 | 0 | 7 |
| EPOR | KRTAP4-12 | 0.703692 | 3 | 0 | 3 |
| EPOR | NDST4 | 0.702145 | 3 | 0 | 3 |
| EPOR | BCAN | 0.700983 | 8 | 0 | 7 |
| EPOR | NPHS2 | 0.699842 | 8 | 0 | 7 |
| EPOR | ULK4 | 0.699425 | 4 | 0 | 4 |
| EPOR | C11orf16 | 0.699347 | 7 | 0 | 6 |
For details and further investigation, click here
