| Full name: ataxin 2 like | Alias Symbol: A2lp|A2D | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 11273 | HGNC ID: HGNC:31326 | Ensembl Gene: ENSG00000168488 | OMIM ID: 607931 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ATXN2L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATXN2L | 11273 | 201806_s_at | 0.3013 | 0.2533 | |
| GSE20347 | ATXN2L | 11273 | 201806_s_at | 0.1869 | 0.0402 | |
| GSE23400 | ATXN2L | 11273 | 201806_s_at | 0.1175 | 0.0194 | |
| GSE26886 | ATXN2L | 11273 | 201806_s_at | 0.2072 | 0.2073 | |
| GSE29001 | ATXN2L | 11273 | 201806_s_at | -0.3794 | 0.0270 | |
| GSE38129 | ATXN2L | 11273 | 201806_s_at | 0.1733 | 0.1105 | |
| GSE45670 | ATXN2L | 11273 | 201806_s_at | 0.0644 | 0.6035 | |
| GSE53622 | ATXN2L | 11273 | 58489 | 0.5470 | 0.0000 | |
| GSE53624 | ATXN2L | 11273 | 58489 | 0.4612 | 0.0000 | |
| GSE63941 | ATXN2L | 11273 | 201806_s_at | 1.1123 | 0.0002 | |
| GSE77861 | ATXN2L | 11273 | 201806_s_at | 0.0612 | 0.8215 | |
| GSE97050 | ATXN2L | 11273 | A_33_P3369956 | 0.5972 | 0.0946 | |
| SRP007169 | ATXN2L | 11273 | RNAseq | 1.5395 | 0.0010 | |
| SRP008496 | ATXN2L | 11273 | RNAseq | 1.2884 | 0.0000 | |
| SRP064894 | ATXN2L | 11273 | RNAseq | 0.3818 | 0.0604 | |
| SRP133303 | ATXN2L | 11273 | RNAseq | 0.5210 | 0.0001 | |
| SRP159526 | ATXN2L | 11273 | RNAseq | 0.5611 | 0.0389 | |
| SRP193095 | ATXN2L | 11273 | RNAseq | 0.6612 | 0.0000 | |
| SRP219564 | ATXN2L | 11273 | RNAseq | 0.3677 | 0.0675 | |
| TCGA | ATXN2L | 11273 | RNAseq | 0.1599 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ATXN2L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATXN2L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATXN2L | 11273 | 5 | 5 | 20 | |
| GSE20123 | ATXN2L | 11273 | 5 | 4 | 21 | |
| GSE43470 | ATXN2L | 11273 | 3 | 3 | 37 | |
| GSE46452 | ATXN2L | 11273 | 38 | 1 | 20 | |
| GSE47630 | ATXN2L | 11273 | 11 | 7 | 22 | |
| GSE54993 | ATXN2L | 11273 | 3 | 5 | 62 | |
| GSE54994 | ATXN2L | 11273 | 5 | 9 | 39 | |
| GSE60625 | ATXN2L | 11273 | 4 | 0 | 7 | |
| GSE74703 | ATXN2L | 11273 | 3 | 2 | 31 | |
| GSE74704 | ATXN2L | 11273 | 3 | 2 | 15 | |
| TCGA | ATXN2L | 11273 | 20 | 12 | 64 |
Total number of gains: 100; Total number of losses: 50; Total Number of normals: 338.
Somatic mutations of ATXN2L:
Generating mutation plots.
Highly correlated genes for ATXN2L:
Showing top 20/786 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATXN2L | SLC19A1 | 0.782247 | 3 | 0 | 3 |
| ATXN2L | TTC9B | 0.734496 | 3 | 0 | 3 |
| ATXN2L | BRIP1 | 0.723748 | 3 | 0 | 3 |
| ATXN2L | DHX36 | 0.713666 | 3 | 0 | 3 |
| ATXN2L | EPOR | 0.710635 | 6 | 0 | 5 |
| ATXN2L | WDR93 | 0.710005 | 3 | 0 | 3 |
| ATXN2L | TAS2R43 | 0.705067 | 3 | 0 | 3 |
| ATXN2L | PVT1 | 0.696788 | 3 | 0 | 3 |
| ATXN2L | NRM | 0.696182 | 4 | 0 | 4 |
| ATXN2L | LYPD6B | 0.695087 | 3 | 0 | 3 |
| ATXN2L | GGN | 0.694972 | 5 | 0 | 5 |
| ATXN2L | NOVA2 | 0.693626 | 3 | 0 | 3 |
| ATXN2L | TMEM138 | 0.692296 | 3 | 0 | 3 |
| ATXN2L | CAPN15 | 0.689618 | 4 | 0 | 4 |
| ATXN2L | ZNF628 | 0.689509 | 4 | 0 | 4 |
| ATXN2L | TAS2R46 | 0.687782 | 3 | 0 | 3 |
| ATXN2L | OR12D2 | 0.683514 | 3 | 0 | 3 |
| ATXN2L | TMPO-AS1 | 0.679101 | 3 | 0 | 3 |
| ATXN2L | UBE2T | 0.677638 | 4 | 0 | 4 |
| ATXN2L | ETV5 | 0.676309 | 4 | 0 | 4 |
For details and further investigation, click here
