| Full name: exosome component 10 | Alias Symbol: PM-Scl|PM/Scl-100|Rrp6p|RRP6|p2|p3|p4 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 5394 | HGNC ID: HGNC:9138 | Ensembl Gene: ENSG00000171824 | OMIM ID: 605960 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOSC10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOSC10 | 5394 | 207541_s_at | 0.3706 | 0.4425 | |
| GSE20347 | EXOSC10 | 5394 | 207541_s_at | 0.0928 | 0.5804 | |
| GSE23400 | EXOSC10 | 5394 | 207541_s_at | 0.2832 | 0.0000 | |
| GSE26886 | EXOSC10 | 5394 | 207541_s_at | 0.6108 | 0.0028 | |
| GSE29001 | EXOSC10 | 5394 | 207541_s_at | 0.3484 | 0.2441 | |
| GSE38129 | EXOSC10 | 5394 | 207541_s_at | 0.1732 | 0.1476 | |
| GSE45670 | EXOSC10 | 5394 | 207541_s_at | 0.1902 | 0.2422 | |
| GSE53622 | EXOSC10 | 5394 | 38890 | 0.1143 | 0.1221 | |
| GSE53624 | EXOSC10 | 5394 | 38890 | 0.1804 | 0.0015 | |
| GSE63941 | EXOSC10 | 5394 | 207541_s_at | 0.8744 | 0.0057 | |
| GSE77861 | EXOSC10 | 5394 | 207541_s_at | 0.1011 | 0.7314 | |
| GSE97050 | EXOSC10 | 5394 | A_23_P62868 | 0.1209 | 0.6193 | |
| SRP007169 | EXOSC10 | 5394 | RNAseq | 0.5326 | 0.3051 | |
| SRP008496 | EXOSC10 | 5394 | RNAseq | 0.4715 | 0.1253 | |
| SRP064894 | EXOSC10 | 5394 | RNAseq | 0.4184 | 0.0011 | |
| SRP133303 | EXOSC10 | 5394 | RNAseq | 0.1400 | 0.2698 | |
| SRP159526 | EXOSC10 | 5394 | RNAseq | 0.1646 | 0.6603 | |
| SRP193095 | EXOSC10 | 5394 | RNAseq | 0.2253 | 0.0030 | |
| SRP219564 | EXOSC10 | 5394 | RNAseq | -0.0853 | 0.6851 | |
| TCGA | EXOSC10 | 5394 | RNAseq | 0.0681 | 0.1501 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EXOSC10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOSC10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOSC10 | 5394 | 0 | 5 | 25 | |
| GSE20123 | EXOSC10 | 5394 | 0 | 4 | 26 | |
| GSE43470 | EXOSC10 | 5394 | 6 | 5 | 32 | |
| GSE46452 | EXOSC10 | 5394 | 7 | 1 | 51 | |
| GSE47630 | EXOSC10 | 5394 | 8 | 4 | 28 | |
| GSE54993 | EXOSC10 | 5394 | 3 | 1 | 66 | |
| GSE54994 | EXOSC10 | 5394 | 11 | 4 | 38 | |
| GSE60625 | EXOSC10 | 5394 | 0 | 0 | 11 | |
| GSE74703 | EXOSC10 | 5394 | 5 | 3 | 28 | |
| GSE74704 | EXOSC10 | 5394 | 0 | 0 | 20 | |
| TCGA | EXOSC10 | 5394 | 10 | 22 | 64 |
Total number of gains: 50; Total number of losses: 49; Total Number of normals: 389.
Somatic mutations of EXOSC10:
Generating mutation plots.
Highly correlated genes for EXOSC10:
Showing top 20/834 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOSC10 | ZNF121 | 0.830819 | 3 | 0 | 3 |
| EXOSC10 | RPL7L1 | 0.823193 | 3 | 0 | 3 |
| EXOSC10 | ARMC10 | 0.779922 | 3 | 0 | 3 |
| EXOSC10 | KDM2A | 0.774915 | 3 | 0 | 3 |
| EXOSC10 | THEM4 | 0.772027 | 3 | 0 | 3 |
| EXOSC10 | PET117 | 0.771398 | 3 | 0 | 3 |
| EXOSC10 | RFNG | 0.769909 | 3 | 0 | 3 |
| EXOSC10 | ZNF766 | 0.76953 | 3 | 0 | 3 |
| EXOSC10 | ZMYND19 | 0.766427 | 3 | 0 | 3 |
| EXOSC10 | RICTOR | 0.765986 | 3 | 0 | 3 |
| EXOSC10 | C20orf27 | 0.76571 | 3 | 0 | 3 |
| EXOSC10 | DNAJC13 | 0.765394 | 3 | 0 | 3 |
| EXOSC10 | COQ4 | 0.75899 | 3 | 0 | 3 |
| EXOSC10 | MRPL55 | 0.757283 | 3 | 0 | 3 |
| EXOSC10 | PCID2 | 0.756828 | 4 | 0 | 4 |
| EXOSC10 | RCHY1 | 0.753783 | 3 | 0 | 3 |
| EXOSC10 | ZKSCAN4 | 0.75188 | 3 | 0 | 3 |
| EXOSC10 | CELF1 | 0.751709 | 4 | 0 | 3 |
| EXOSC10 | ZFAS1 | 0.748984 | 3 | 0 | 3 |
| EXOSC10 | TSNARE1 | 0.742328 | 3 | 0 | 3 |
For details and further investigation, click here
