CELF1

 

Full name: CUGBP Elav-like family member 1 Alias Symbol: CUG-BP|hNab50|BRUNOL2|NAB50|CUGBP|NAPOR|EDEN-BP
Type: protein-coding gene Cytoband: 11p11.2
Entrez ID: 10658 HGNC ID: HGNC:2549 Ensembl Gene: ENSG00000149187 OMIM ID: 601074
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CELF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CELF1 10658 221743_at 0.3305 0.3351
GSE20347 CELF1 10658 221743_at 0.3377 0.0008
GSE23400 CELF1 10658 209489_at -0.0691 0.2629
GSE26886 CELF1 10658 221743_at 0.2853 0.2440
GSE29001 CELF1 10658 221743_at 0.2040 0.3490
GSE38129 CELF1 10658 221743_at 0.2659 0.0035
GSE45670 CELF1 10658 221743_at 0.1396 0.1562
GSE53622 CELF1 10658 156760 0.2412 0.0000
GSE53624 CELF1 10658 39230 0.5041 0.0000
GSE63941 CELF1 10658 221743_at -0.1489 0.5811
GSE77861 CELF1 10658 221743_at 0.3928 0.0147
GSE97050 CELF1 10658 A_23_P318396 0.1345 0.5840
SRP007169 CELF1 10658 RNAseq 0.3486 0.3423
SRP008496 CELF1 10658 RNAseq 0.3639 0.0772
SRP064894 CELF1 10658 RNAseq 0.2446 0.0451
SRP133303 CELF1 10658 RNAseq 0.3331 0.0025
SRP159526 CELF1 10658 RNAseq 0.1407 0.5809
SRP193095 CELF1 10658 RNAseq 0.1601 0.0600
SRP219564 CELF1 10658 RNAseq 0.1172 0.5271
TCGA CELF1 10658 RNAseq 0.0227 0.6061

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CELF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CELF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CELF1 10658 3 7 20
GSE20123 CELF1 10658 3 6 21
GSE43470 CELF1 10658 1 4 38
GSE46452 CELF1 10658 8 5 46
GSE47630 CELF1 10658 3 9 28
GSE54993 CELF1 10658 3 0 67
GSE54994 CELF1 10658 1 11 41
GSE60625 CELF1 10658 0 0 11
GSE74703 CELF1 10658 1 2 33
GSE74704 CELF1 10658 2 4 14
TCGA CELF1 10658 10 20 66

Total number of gains: 35; Total number of losses: 68; Total Number of normals: 385.  

 

Somatic mutations of CELF1:

 

Generating mutation plots.

 

Highly correlated genes for CELF1:

 

Showing top 20/987 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CELF1CRTC20.82367303
CELF1CCDC1500.795522303
CELF1PLEKHA30.788816303
CELF1ANAPC40.787167303
CELF1PHOSPHO20.768442303
CELF1LMLN0.764788404
CELF1ZNF1460.762845606
CELF1WDR750.761928404
CELF1NBEAL10.759861303
CELF1KLHL80.759598303
CELF1EXOSC100.751709403
CELF1ACSL10.74852303
CELF1NOM10.7457404
CELF1GAR10.745235303
CELF1PAK1IP10.743987505
CELF1DHX360.74208504
CELF1DDIT30.738095303
CELF1MTPAP0.735627404
CELF1EMG10.73538303
CELF1ALS20.734694404

For details and further investigation, click here