| Full name: lysine demethylase 2A | Alias Symbol: KIAA1004|FBL11|LILINA|DKFZP434M1735|FBL7|FLJ00115|CXXC8|JHDM1A | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 22992 | HGNC ID: HGNC:13606 | Ensembl Gene: ENSG00000173120 | OMIM ID: 605657 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KDM2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KDM2A | 22992 | 208988_at | 0.5189 | 0.4385 | |
| GSE20347 | KDM2A | 22992 | 208988_at | -0.0034 | 0.9852 | |
| GSE23400 | KDM2A | 22992 | 208987_s_at | -0.1048 | 0.2145 | |
| GSE26886 | KDM2A | 22992 | 208988_at | -0.1677 | 0.4630 | |
| GSE29001 | KDM2A | 22992 | 208988_at | 0.0061 | 0.9786 | |
| GSE38129 | KDM2A | 22992 | 208988_at | -0.0154 | 0.9233 | |
| GSE45670 | KDM2A | 22992 | 208988_at | 0.2650 | 0.0971 | |
| GSE53622 | KDM2A | 22992 | 159446 | -0.1250 | 0.1294 | |
| GSE53624 | KDM2A | 22992 | 159446 | 0.0179 | 0.8154 | |
| GSE63941 | KDM2A | 22992 | 208988_at | 0.1463 | 0.8074 | |
| GSE77861 | KDM2A | 22992 | 208988_at | 0.1613 | 0.4888 | |
| GSE97050 | KDM2A | 22992 | A_23_P83917 | 0.0607 | 0.8603 | |
| SRP007169 | KDM2A | 22992 | RNAseq | -0.8345 | 0.0022 | |
| SRP008496 | KDM2A | 22992 | RNAseq | -0.9044 | 0.0000 | |
| SRP064894 | KDM2A | 22992 | RNAseq | -0.6582 | 0.0001 | |
| SRP133303 | KDM2A | 22992 | RNAseq | -0.0017 | 0.9937 | |
| SRP159526 | KDM2A | 22992 | RNAseq | -0.2288 | 0.3875 | |
| SRP193095 | KDM2A | 22992 | RNAseq | -0.1359 | 0.2741 | |
| SRP219564 | KDM2A | 22992 | RNAseq | -0.6652 | 0.0310 | |
| TCGA | KDM2A | 22992 | RNAseq | 0.0492 | 0.2424 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KDM2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KDM2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KDM2A | 22992 | 8 | 4 | 18 | |
| GSE20123 | KDM2A | 22992 | 8 | 4 | 18 | |
| GSE43470 | KDM2A | 22992 | 6 | 1 | 36 | |
| GSE46452 | KDM2A | 22992 | 13 | 3 | 43 | |
| GSE47630 | KDM2A | 22992 | 8 | 5 | 27 | |
| GSE54993 | KDM2A | 22992 | 3 | 0 | 67 | |
| GSE54994 | KDM2A | 22992 | 13 | 4 | 36 | |
| GSE60625 | KDM2A | 22992 | 0 | 3 | 8 | |
| GSE74703 | KDM2A | 22992 | 4 | 0 | 32 | |
| GSE74704 | KDM2A | 22992 | 6 | 2 | 12 | |
| TCGA | KDM2A | 22992 | 28 | 8 | 60 |
Total number of gains: 97; Total number of losses: 34; Total Number of normals: 357.
Somatic mutations of KDM2A:
Generating mutation plots.
Highly correlated genes for KDM2A:
Showing top 20/184 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KDM2A | ZNF195 | 0.799872 | 3 | 0 | 3 |
| KDM2A | FAM200A | 0.795608 | 3 | 0 | 3 |
| KDM2A | EXOSC10 | 0.774915 | 3 | 0 | 3 |
| KDM2A | NAA25 | 0.771171 | 3 | 0 | 3 |
| KDM2A | NECAP2 | 0.741557 | 3 | 0 | 3 |
| KDM2A | STX10 | 0.737967 | 3 | 0 | 3 |
| KDM2A | NIPBL | 0.727323 | 3 | 0 | 3 |
| KDM2A | MRPL1 | 0.726339 | 3 | 0 | 3 |
| KDM2A | RRM2B | 0.725999 | 3 | 0 | 3 |
| KDM2A | MRPS5 | 0.718269 | 3 | 0 | 3 |
| KDM2A | NUDT9 | 0.715307 | 3 | 0 | 3 |
| KDM2A | USP19 | 0.714435 | 3 | 0 | 3 |
| KDM2A | ZNF35 | 0.713936 | 3 | 0 | 3 |
| KDM2A | AGPAT3 | 0.712754 | 3 | 0 | 3 |
| KDM2A | SP140L | 0.708776 | 3 | 0 | 3 |
| KDM2A | SFPQ | 0.705743 | 4 | 0 | 3 |
| KDM2A | VEZT | 0.698806 | 3 | 0 | 3 |
| KDM2A | POLH | 0.694804 | 3 | 0 | 3 |
| KDM2A | SLC35C2 | 0.693234 | 4 | 0 | 3 |
| KDM2A | GET4 | 0.69136 | 4 | 0 | 3 |
For details and further investigation, click here
