| Full name: thioesterase superfamily member 4 | Alias Symbol: CTMP | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 117145 | HGNC ID: HGNC:17947 | Ensembl Gene: ENSG00000159445 | OMIM ID: 606388 |
| Drug and gene relationship at DGIdb | |||
THEM4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway |
Expression of THEM4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THEM4 | 117145 | 229253_at | 0.4646 | 0.6528 | |
| GSE26886 | THEM4 | 117145 | 229253_at | 1.4446 | 0.0000 | |
| GSE45670 | THEM4 | 117145 | 229253_at | 0.4556 | 0.0544 | |
| GSE53622 | THEM4 | 117145 | 108166 | 0.6772 | 0.0000 | |
| GSE53624 | THEM4 | 117145 | 108166 | 0.8036 | 0.0000 | |
| GSE63941 | THEM4 | 117145 | 1553118_at | -0.9246 | 0.3232 | |
| GSE77861 | THEM4 | 117145 | 1553118_at | 0.3646 | 0.1019 | |
| GSE97050 | THEM4 | 117145 | A_33_P3343432 | 0.3879 | 0.2365 | |
| SRP007169 | THEM4 | 117145 | RNAseq | 0.9343 | 0.1145 | |
| SRP008496 | THEM4 | 117145 | RNAseq | 1.4958 | 0.0001 | |
| SRP064894 | THEM4 | 117145 | RNAseq | 0.2561 | 0.0383 | |
| SRP133303 | THEM4 | 117145 | RNAseq | -0.1124 | 0.3219 | |
| SRP159526 | THEM4 | 117145 | RNAseq | 0.6350 | 0.0056 | |
| SRP193095 | THEM4 | 117145 | RNAseq | 0.2104 | 0.0568 | |
| SRP219564 | THEM4 | 117145 | RNAseq | 0.6919 | 0.1385 | |
| TCGA | THEM4 | 117145 | RNAseq | -0.1451 | 0.0973 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by THEM4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THEM4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THEM4 | 117145 | 15 | 0 | 15 | |
| GSE20123 | THEM4 | 117145 | 15 | 0 | 15 | |
| GSE43470 | THEM4 | 117145 | 8 | 2 | 33 | |
| GSE46452 | THEM4 | 117145 | 2 | 1 | 56 | |
| GSE47630 | THEM4 | 117145 | 15 | 0 | 25 | |
| GSE54993 | THEM4 | 117145 | 0 | 4 | 66 | |
| GSE54994 | THEM4 | 117145 | 15 | 0 | 38 | |
| GSE60625 | THEM4 | 117145 | 0 | 0 | 11 | |
| GSE74703 | THEM4 | 117145 | 7 | 1 | 28 | |
| GSE74704 | THEM4 | 117145 | 7 | 0 | 13 | |
| TCGA | THEM4 | 117145 | 39 | 2 | 55 |
Total number of gains: 123; Total number of losses: 10; Total Number of normals: 355.
Somatic mutations of THEM4:
Generating mutation plots.
Highly correlated genes for THEM4:
Showing top 20/927 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THEM4 | KTN1 | 0.862698 | 3 | 0 | 3 |
| THEM4 | PHF20 | 0.839294 | 3 | 0 | 3 |
| THEM4 | PIK3R3 | 0.8269 | 3 | 0 | 3 |
| THEM4 | EIF5B | 0.81084 | 3 | 0 | 3 |
| THEM4 | PET117 | 0.801626 | 4 | 0 | 4 |
| THEM4 | LIG3 | 0.801141 | 3 | 0 | 3 |
| THEM4 | LRP4 | 0.7993 | 3 | 0 | 3 |
| THEM4 | ZFYVE27 | 0.794239 | 3 | 0 | 3 |
| THEM4 | SEL1L3 | 0.793094 | 3 | 0 | 3 |
| THEM4 | ADCY3 | 0.792035 | 3 | 0 | 3 |
| THEM4 | ZNF322 | 0.789381 | 3 | 0 | 3 |
| THEM4 | MGAT4B | 0.779522 | 3 | 0 | 3 |
| THEM4 | CMC1 | 0.777924 | 3 | 0 | 3 |
| THEM4 | ZHX2 | 0.776541 | 3 | 0 | 3 |
| THEM4 | EXOSC10 | 0.772027 | 3 | 0 | 3 |
| THEM4 | LTBR | 0.768683 | 3 | 0 | 3 |
| THEM4 | ALKBH6 | 0.76841 | 4 | 0 | 4 |
| THEM4 | SEC22C | 0.764387 | 3 | 0 | 3 |
| THEM4 | DDX54 | 0.763176 | 3 | 0 | 3 |
| THEM4 | SAFB2 | 0.759228 | 3 | 0 | 3 |
For details and further investigation, click here
