| Full name: coenzyme Q4 | Alias Symbol: CGI-92 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 51117 | HGNC ID: HGNC:19693 | Ensembl Gene: ENSG00000167113 | OMIM ID: 612898 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COQ4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COQ4 | 51117 | 228931_at | 0.2740 | 0.5815 | |
| GSE20347 | COQ4 | 51117 | 218328_at | -0.8340 | 0.0000 | |
| GSE23400 | COQ4 | 51117 | 218328_at | -0.2198 | 0.0026 | |
| GSE26886 | COQ4 | 51117 | 228931_at | 1.1355 | 0.0000 | |
| GSE29001 | COQ4 | 51117 | 218328_at | -0.6375 | 0.0045 | |
| GSE38129 | COQ4 | 51117 | 218328_at | -0.5029 | 0.0000 | |
| GSE45670 | COQ4 | 51117 | 228931_at | 0.2021 | 0.3001 | |
| GSE53622 | COQ4 | 51117 | 78465 | 0.1811 | 0.1311 | |
| GSE53624 | COQ4 | 51117 | 78465 | -0.1441 | 0.0844 | |
| GSE63941 | COQ4 | 51117 | 228931_at | 0.8157 | 0.0968 | |
| GSE77861 | COQ4 | 51117 | 218328_at | -0.3003 | 0.1288 | |
| GSE97050 | COQ4 | 51117 | A_33_P3392330 | 0.0669 | 0.7985 | |
| SRP007169 | COQ4 | 51117 | RNAseq | -1.5538 | 0.0008 | |
| SRP008496 | COQ4 | 51117 | RNAseq | -1.3065 | 0.0000 | |
| SRP064894 | COQ4 | 51117 | RNAseq | 0.1453 | 0.6287 | |
| SRP133303 | COQ4 | 51117 | RNAseq | -0.4662 | 0.0173 | |
| SRP159526 | COQ4 | 51117 | RNAseq | -0.3688 | 0.0893 | |
| SRP193095 | COQ4 | 51117 | RNAseq | -0.6795 | 0.0000 | |
| SRP219564 | COQ4 | 51117 | RNAseq | -0.3859 | 0.2789 | |
| TCGA | COQ4 | 51117 | RNAseq | -0.0443 | 0.4406 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by COQ4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COQ4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COQ4 | 51117 | 6 | 9 | 15 | |
| GSE20123 | COQ4 | 51117 | 6 | 9 | 15 | |
| GSE43470 | COQ4 | 51117 | 5 | 7 | 31 | |
| GSE46452 | COQ4 | 51117 | 6 | 13 | 40 | |
| GSE47630 | COQ4 | 51117 | 3 | 16 | 21 | |
| GSE54993 | COQ4 | 51117 | 3 | 3 | 64 | |
| GSE54994 | COQ4 | 51117 | 11 | 8 | 34 | |
| GSE60625 | COQ4 | 51117 | 0 | 0 | 11 | |
| GSE74703 | COQ4 | 51117 | 5 | 5 | 26 | |
| GSE74704 | COQ4 | 51117 | 3 | 7 | 10 | |
| TCGA | COQ4 | 51117 | 27 | 24 | 45 |
Total number of gains: 75; Total number of losses: 101; Total Number of normals: 312.
Somatic mutations of COQ4:
Generating mutation plots.
Highly correlated genes for COQ4:
Showing top 20/265 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COQ4 | SNRPF | 0.83393 | 3 | 0 | 3 |
| COQ4 | RPL7L1 | 0.781534 | 3 | 0 | 3 |
| COQ4 | MED26 | 0.778772 | 3 | 0 | 3 |
| COQ4 | ACSS2 | 0.771072 | 3 | 0 | 3 |
| COQ4 | EXOSC10 | 0.75899 | 3 | 0 | 3 |
| COQ4 | UTP14A | 0.753937 | 3 | 0 | 3 |
| COQ4 | CHCHD2 | 0.751542 | 3 | 0 | 3 |
| COQ4 | GTPBP10 | 0.750272 | 3 | 0 | 3 |
| COQ4 | NOC2L | 0.748035 | 3 | 0 | 3 |
| COQ4 | ESCO1 | 0.747655 | 3 | 0 | 3 |
| COQ4 | FAM204A | 0.737009 | 3 | 0 | 3 |
| COQ4 | LRRC58 | 0.735612 | 3 | 0 | 3 |
| COQ4 | C2orf76 | 0.728268 | 3 | 0 | 3 |
| COQ4 | RRP36 | 0.725326 | 3 | 0 | 3 |
| COQ4 | TRAP1 | 0.725316 | 3 | 0 | 3 |
| COQ4 | MRPS34 | 0.721327 | 3 | 0 | 3 |
| COQ4 | FBXO36 | 0.720195 | 3 | 0 | 3 |
| COQ4 | ANAPC5 | 0.718849 | 3 | 0 | 3 |
| COQ4 | KLRC3 | 0.716416 | 3 | 0 | 3 |
| COQ4 | HEATR5A | 0.712503 | 3 | 0 | 3 |
For details and further investigation, click here
