| Full name: RPTOR independent companion of MTOR complex 2 | Alias Symbol: MGC39830|AVO3|PIA|KIAA1999 | ||
| Type: protein-coding gene | Cytoband: 5p13.1 | ||
| Entrez ID: 253260 | HGNC ID: HGNC:28611 | Ensembl Gene: ENSG00000164327 | OMIM ID: 609022 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RICTOR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of RICTOR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RICTOR | 253260 | 226312_at | 0.1557 | 0.4210 | |
| GSE26886 | RICTOR | 253260 | 226312_at | 0.8126 | 0.0055 | |
| GSE45670 | RICTOR | 253260 | 226312_at | 0.0263 | 0.9095 | |
| GSE53622 | RICTOR | 253260 | 33466 | 0.0969 | 0.1782 | |
| GSE53624 | RICTOR | 253260 | 33466 | 0.1852 | 0.0018 | |
| GSE63941 | RICTOR | 253260 | 226312_at | -0.0609 | 0.9234 | |
| GSE77861 | RICTOR | 253260 | 228248_at | 0.5810 | 0.1934 | |
| GSE97050 | RICTOR | 253260 | A_32_P193322 | -0.1058 | 0.6334 | |
| SRP007169 | RICTOR | 253260 | RNAseq | 0.5290 | 0.2194 | |
| SRP008496 | RICTOR | 253260 | RNAseq | 0.3888 | 0.1961 | |
| SRP064894 | RICTOR | 253260 | RNAseq | -0.2634 | 0.3495 | |
| SRP133303 | RICTOR | 253260 | RNAseq | 0.1247 | 0.4400 | |
| SRP159526 | RICTOR | 253260 | RNAseq | -0.1095 | 0.5670 | |
| SRP193095 | RICTOR | 253260 | RNAseq | 0.0861 | 0.4444 | |
| SRP219564 | RICTOR | 253260 | RNAseq | -0.0541 | 0.8508 | |
| TCGA | RICTOR | 253260 | RNAseq | 0.0311 | 0.6413 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RICTOR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RICTOR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RICTOR | 253260 | 10 | 0 | 20 | |
| GSE20123 | RICTOR | 253260 | 10 | 0 | 20 | |
| GSE43470 | RICTOR | 253260 | 17 | 0 | 26 | |
| GSE46452 | RICTOR | 253260 | 5 | 22 | 32 | |
| GSE47630 | RICTOR | 253260 | 6 | 12 | 22 | |
| GSE54993 | RICTOR | 253260 | 5 | 4 | 61 | |
| GSE54994 | RICTOR | 253260 | 25 | 2 | 26 | |
| GSE60625 | RICTOR | 253260 | 0 | 0 | 11 | |
| GSE74703 | RICTOR | 253260 | 13 | 0 | 23 | |
| GSE74704 | RICTOR | 253260 | 8 | 0 | 12 | |
| TCGA | RICTOR | 253260 | 54 | 5 | 37 |
Total number of gains: 153; Total number of losses: 45; Total Number of normals: 290.
Somatic mutations of RICTOR:
Generating mutation plots.
Highly correlated genes for RICTOR:
Showing top 20/555 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RICTOR | FANCL | 0.857847 | 4 | 0 | 4 |
| RICTOR | XYLT2 | 0.811335 | 3 | 0 | 3 |
| RICTOR | TNFRSF10B | 0.807343 | 3 | 0 | 3 |
| RICTOR | SCAI | 0.806472 | 3 | 0 | 3 |
| RICTOR | ENTPD4 | 0.805178 | 3 | 0 | 3 |
| RICTOR | STAT2 | 0.804247 | 4 | 0 | 4 |
| RICTOR | DGCR2 | 0.802734 | 3 | 0 | 3 |
| RICTOR | DHX40 | 0.789205 | 3 | 0 | 3 |
| RICTOR | SPRED1 | 0.788021 | 3 | 0 | 3 |
| RICTOR | HAUS6 | 0.78731 | 3 | 0 | 3 |
| RICTOR | GPATCH1 | 0.785646 | 3 | 0 | 3 |
| RICTOR | GSR | 0.783831 | 3 | 0 | 3 |
| RICTOR | CPSF6 | 0.774983 | 3 | 0 | 3 |
| RICTOR | TAF4B | 0.773402 | 4 | 0 | 4 |
| RICTOR | KIAA1324L | 0.773236 | 3 | 0 | 3 |
| RICTOR | COCH | 0.770882 | 3 | 0 | 3 |
| RICTOR | DDX18 | 0.767924 | 3 | 0 | 3 |
| RICTOR | CHERP | 0.766398 | 3 | 0 | 3 |
| RICTOR | EXOSC10 | 0.765986 | 3 | 0 | 3 |
| RICTOR | USP48 | 0.763987 | 3 | 0 | 3 |
For details and further investigation, click here
