| Full name: major histocompatibility complex, class II, DR beta 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3127 | HGNC ID: HGNC:4953 | Ensembl Gene: ENSG00000198502 | OMIM ID: 604776 |
| Drug and gene relationship at DGIdb | |||
HLA-DRB5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DRB5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | HLA-DRB5 | 3127 | 48612 | 0.0921 | 0.6921 | |
| GSE53624 | HLA-DRB5 | 3127 | 48612 | -0.1514 | 0.3459 | |
| GSE97050 | HLA-DRB5 | 3127 | A_23_P45099 | 0.7446 | 0.2144 | |
| SRP007169 | HLA-DRB5 | 3127 | RNAseq | -0.7064 | 0.4124 | |
| TCGA | HLA-DRB5 | 3127 | RNAseq | 0.0332 | 0.8800 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HLA-DRB5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DRB5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DRB5 | 3127 | 7 | 0 | 23 | |
| GSE20123 | HLA-DRB5 | 3127 | 7 | 0 | 23 | |
| GSE43470 | HLA-DRB5 | 3127 | 5 | 1 | 37 | |
| GSE46452 | HLA-DRB5 | 3127 | 1 | 10 | 48 | |
| GSE47630 | HLA-DRB5 | 3127 | 7 | 4 | 29 | |
| GSE54993 | HLA-DRB5 | 3127 | 2 | 1 | 67 | |
| GSE54994 | HLA-DRB5 | 3127 | 11 | 4 | 38 | |
| GSE60625 | HLA-DRB5 | 3127 | 0 | 1 | 10 | |
| GSE74703 | HLA-DRB5 | 3127 | 5 | 0 | 31 | |
| GSE74704 | HLA-DRB5 | 3127 | 3 | 0 | 17 |
Total number of gains: 48; Total number of losses: 21; Total Number of normals: 323.
Somatic mutations of HLA-DRB5:
Generating mutation plots.
Highly correlated genes for HLA-DRB5:
Showing all 11 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DRB5 | HLA-DQB2 | 0.828422 | 3 | 0 | 3 |
| HLA-DRB5 | HLA-DQB1 | 0.77651 | 3 | 0 | 3 |
| HLA-DRB5 | HLA-DMA | 0.698682 | 3 | 0 | 3 |
| HLA-DRB5 | HLA-DRA | 0.685005 | 3 | 0 | 3 |
| HLA-DRB5 | MS4A6A | 0.683976 | 3 | 0 | 3 |
| HLA-DRB5 | CD74 | 0.678838 | 3 | 0 | 3 |
| HLA-DRB5 | PARVG | 0.670773 | 3 | 0 | 3 |
| HLA-DRB5 | MYO1F | 0.664791 | 3 | 0 | 3 |
| HLA-DRB5 | ITGB2 | 0.628293 | 3 | 0 | 3 |
| HLA-DRB5 | CYBB | 0.551929 | 3 | 0 | 3 |
| HLA-DRB5 | AIF1 | 0.546668 | 3 | 0 | 3 |
For details and further investigation, click here
