| Full name: CD74 molecule | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q33.1 | ||
| Entrez ID: 972 | HGNC ID: HGNC:1697 | Ensembl Gene: ENSG00000019582 | OMIM ID: 142790 |
| Drug and gene relationship at DGIdb | |||
CD74 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of CD74:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD74 | 972 | 209619_at | 0.0692 | 0.9674 | |
| GSE20347 | CD74 | 972 | 209619_at | -0.3772 | 0.2640 | |
| GSE23400 | CD74 | 972 | 209619_at | 0.0699 | 0.7353 | |
| GSE26886 | CD74 | 972 | 209619_at | -0.0970 | 0.8643 | |
| GSE29001 | CD74 | 972 | 209619_at | 0.0945 | 0.8145 | |
| GSE38129 | CD74 | 972 | 209619_at | -0.3925 | 0.1570 | |
| GSE45670 | CD74 | 972 | 209619_at | -0.1700 | 0.7003 | |
| GSE53622 | CD74 | 972 | 69406 | -0.3755 | 0.0038 | |
| GSE53624 | CD74 | 972 | 69406 | -0.4286 | 0.0005 | |
| GSE63941 | CD74 | 972 | 209619_at | 0.7741 | 0.6349 | |
| GSE77861 | CD74 | 972 | 209619_at | -0.5320 | 0.0625 | |
| GSE97050 | CD74 | 972 | A_23_P70095 | 0.9836 | 0.1623 | |
| SRP007169 | CD74 | 972 | RNAseq | 0.9050 | 0.1651 | |
| SRP008496 | CD74 | 972 | RNAseq | 0.5335 | 0.2047 | |
| SRP064894 | CD74 | 972 | RNAseq | 0.7685 | 0.0319 | |
| SRP133303 | CD74 | 972 | RNAseq | -0.0583 | 0.8111 | |
| SRP159526 | CD74 | 972 | RNAseq | -0.7295 | 0.2630 | |
| SRP193095 | CD74 | 972 | RNAseq | -0.0463 | 0.8358 | |
| SRP219564 | CD74 | 972 | RNAseq | 1.1676 | 0.0024 | |
| TCGA | CD74 | 972 | RNAseq | 0.0322 | 0.7033 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CD74 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD74:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD74 | 972 | 1 | 12 | 17 | |
| GSE20123 | CD74 | 972 | 1 | 12 | 17 | |
| GSE43470 | CD74 | 972 | 1 | 10 | 32 | |
| GSE46452 | CD74 | 972 | 0 | 27 | 32 | |
| GSE47630 | CD74 | 972 | 0 | 20 | 20 | |
| GSE54993 | CD74 | 972 | 9 | 1 | 60 | |
| GSE54994 | CD74 | 972 | 2 | 15 | 36 | |
| GSE60625 | CD74 | 972 | 0 | 0 | 11 | |
| GSE74703 | CD74 | 972 | 1 | 7 | 28 | |
| GSE74704 | CD74 | 972 | 1 | 7 | 12 | |
| TCGA | CD74 | 972 | 5 | 37 | 54 |
Total number of gains: 21; Total number of losses: 148; Total Number of normals: 319.
Somatic mutations of CD74:
Generating mutation plots.
Highly correlated genes for CD74:
Showing top 20/453 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD74 | HLA-DMA | 0.853896 | 13 | 0 | 12 |
| CD74 | HLA-DRA | 0.846017 | 12 | 0 | 12 |
| CD74 | HLA-DMB | 0.813161 | 12 | 0 | 11 |
| CD74 | HLA-DPA1 | 0.794225 | 13 | 0 | 12 |
| CD74 | HLA-DPB1 | 0.775799 | 13 | 0 | 12 |
| CD74 | HLA-DOA | 0.748698 | 6 | 0 | 5 |
| CD74 | HLA-DQB1 | 0.747606 | 13 | 0 | 12 |
| CD74 | SNX12 | 0.731627 | 3 | 0 | 3 |
| CD74 | CD53 | 0.720044 | 9 | 0 | 8 |
| CD74 | PREX1 | 0.71975 | 4 | 0 | 3 |
| CD74 | TNFSF8 | 0.716266 | 5 | 0 | 4 |
| CD74 | C1QC | 0.715849 | 7 | 0 | 7 |
| CD74 | CD2 | 0.714061 | 12 | 0 | 11 |
| CD74 | EVI2B | 0.711219 | 12 | 0 | 11 |
| CD74 | CD48 | 0.709752 | 10 | 0 | 10 |
| CD74 | CD3D | 0.707888 | 13 | 0 | 12 |
| CD74 | PLCB2 | 0.707218 | 5 | 0 | 5 |
| CD74 | GIMAP5 | 0.703537 | 4 | 0 | 4 |
| CD74 | LAPTM5 | 0.700727 | 11 | 0 | 10 |
| CD74 | ARHGDIB | 0.69901 | 13 | 0 | 11 |
For details and further investigation, click here
