| Full name: major histocompatibility complex, class II, DR alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3122 | HGNC ID: HGNC:4947 | Ensembl Gene: ENSG00000204287 | OMIM ID: 142860 |
| Drug and gene relationship at DGIdb | |||
HLA-DRA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DRA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DRA | 3122 | 208894_at | -0.0785 | 0.9751 | |
| GSE20347 | HLA-DRA | 3122 | 208894_at | -0.7231 | 0.1312 | |
| GSE23400 | HLA-DRA | 3122 | 208894_at | 0.1550 | 0.5030 | |
| GSE26886 | HLA-DRA | 3122 | 208894_at | -2.7385 | 0.0006 | |
| GSE29001 | HLA-DRA | 3122 | 208894_at | 0.3319 | 0.5913 | |
| GSE38129 | HLA-DRA | 3122 | 208894_at | -0.4287 | 0.3063 | |
| GSE45670 | HLA-DRA | 3122 | 208894_at | -0.5891 | 0.3214 | |
| GSE53622 | HLA-DRA | 3122 | 18721 | 0.0743 | 0.5816 | |
| GSE53624 | HLA-DRA | 3122 | 18721 | -0.2789 | 0.0294 | |
| GSE63941 | HLA-DRA | 3122 | 208894_at | 1.4369 | 0.3889 | |
| GSE77861 | HLA-DRA | 3122 | 208894_at | -0.6543 | 0.2733 | |
| GSE97050 | HLA-DRA | 3122 | A_32_P87697 | 0.9071 | 0.1927 | |
| SRP007169 | HLA-DRA | 3122 | RNAseq | 1.1881 | 0.0404 | |
| SRP008496 | HLA-DRA | 3122 | RNAseq | 0.8706 | 0.0200 | |
| SRP064894 | HLA-DRA | 3122 | RNAseq | 0.3838 | 0.1702 | |
| SRP133303 | HLA-DRA | 3122 | RNAseq | 0.1398 | 0.5870 | |
| SRP159526 | HLA-DRA | 3122 | RNAseq | -0.4649 | 0.5876 | |
| SRP193095 | HLA-DRA | 3122 | RNAseq | -0.1227 | 0.6134 | |
| SRP219564 | HLA-DRA | 3122 | RNAseq | 0.9668 | 0.0240 | |
| TCGA | HLA-DRA | 3122 | RNAseq | 0.1416 | 0.1570 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by HLA-DRA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DRA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DRA | 3122 | 7 | 0 | 23 | |
| GSE20123 | HLA-DRA | 3122 | 7 | 0 | 23 | |
| GSE43470 | HLA-DRA | 3122 | 5 | 1 | 37 | |
| GSE46452 | HLA-DRA | 3122 | 1 | 10 | 48 | |
| GSE47630 | HLA-DRA | 3122 | 7 | 4 | 29 | |
| GSE54993 | HLA-DRA | 3122 | 2 | 1 | 67 | |
| GSE54994 | HLA-DRA | 3122 | 11 | 4 | 38 | |
| GSE60625 | HLA-DRA | 3122 | 0 | 1 | 10 | |
| GSE74703 | HLA-DRA | 3122 | 5 | 0 | 31 | |
| GSE74704 | HLA-DRA | 3122 | 3 | 0 | 17 |
Total number of gains: 48; Total number of losses: 21; Total Number of normals: 323.
Somatic mutations of HLA-DRA:
Generating mutation plots.
Highly correlated genes for HLA-DRA:
Showing top 20/488 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DRA | HLA-DMA | 0.852657 | 13 | 0 | 13 |
| HLA-DRA | CD74 | 0.846017 | 12 | 0 | 12 |
| HLA-DRA | HLA-DQB1 | 0.834083 | 13 | 0 | 13 |
| HLA-DRA | HLA-DPB1 | 0.809799 | 13 | 0 | 12 |
| HLA-DRA | HLA-DPA1 | 0.806811 | 13 | 0 | 13 |
| HLA-DRA | HLA-DMB | 0.781182 | 13 | 0 | 13 |
| HLA-DRA | HLA-DQA2 | 0.747739 | 3 | 0 | 3 |
| HLA-DRA | FYTTD1 | 0.73151 | 3 | 0 | 3 |
| HLA-DRA | ALOX5AP | 0.716041 | 10 | 0 | 9 |
| HLA-DRA | LAPTM5 | 0.713872 | 12 | 0 | 12 |
| HLA-DRA | C1QC | 0.711771 | 7 | 0 | 7 |
| HLA-DRA | MS4A6A | 0.702516 | 11 | 0 | 9 |
| HLA-DRA | EVI2B | 0.699577 | 11 | 0 | 11 |
| HLA-DRA | MFAP3 | 0.695981 | 3 | 0 | 3 |
| HLA-DRA | HCST | 0.685407 | 8 | 0 | 8 |
| HLA-DRA | HLA-DRB5 | 0.685005 | 3 | 0 | 3 |
| HLA-DRA | HVCN1 | 0.683555 | 6 | 0 | 6 |
| HLA-DRA | HLA-DQA1 | 0.682577 | 11 | 0 | 7 |
| HLA-DRA | PTPRC | 0.678253 | 10 | 0 | 9 |
| HLA-DRA | TRG-AS1 | 0.676615 | 3 | 0 | 3 |
For details and further investigation, click here
