| Full name: major histocompatibility complex, class II, DQ beta 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3120 | HGNC ID: HGNC:4945 | Ensembl Gene: ENSG00000232629 | OMIM ID: 615161 |
| Drug and gene relationship at DGIdb | |||
Expression of HLA-DQB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DQB2 | 3120 | 215536_at | -1.1323 | 0.2692 | |
| GSE20347 | HLA-DQB2 | 3120 | 215536_at | -0.9582 | 0.0000 | |
| GSE23400 | HLA-DQB2 | 3120 | 215536_at | -0.6710 | 0.0000 | |
| GSE26886 | HLA-DQB2 | 3120 | 215536_at | -2.0775 | 0.0001 | |
| GSE29001 | HLA-DQB2 | 3120 | 215536_at | -0.7275 | 0.0210 | |
| GSE38129 | HLA-DQB2 | 3120 | 215536_at | -0.8384 | 0.0002 | |
| GSE45670 | HLA-DQB2 | 3120 | 215536_at | -0.9771 | 0.0011 | |
| GSE53622 | HLA-DQB2 | 3120 | 119547 | -0.1443 | 0.1947 | |
| GSE53624 | HLA-DQB2 | 3120 | 119547 | -0.3434 | 0.0003 | |
| GSE63941 | HLA-DQB2 | 3120 | 215536_at | -0.2974 | 0.0867 | |
| GSE77861 | HLA-DQB2 | 3120 | 215536_at | -1.2024 | 0.0006 | |
| GSE97050 | HLA-DQB2 | 3120 | A_23_P19510 | 0.8343 | 0.1813 | |
| SRP007169 | HLA-DQB2 | 3120 | RNAseq | -3.1213 | 0.0000 | |
| SRP064894 | HLA-DQB2 | 3120 | RNAseq | -1.9622 | 0.0000 | |
| SRP133303 | HLA-DQB2 | 3120 | RNAseq | -1.7939 | 0.0001 | |
| SRP159526 | HLA-DQB2 | 3120 | RNAseq | -2.8662 | 0.0009 | |
| SRP219564 | HLA-DQB2 | 3120 | RNAseq | -2.1233 | 0.0258 | |
| TCGA | HLA-DQB2 | 3120 | RNAseq | 0.7107 | 0.0175 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by HLA-DQB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DQB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DQB2 | 3120 | 7 | 0 | 23 | |
| GSE20123 | HLA-DQB2 | 3120 | 7 | 0 | 23 | |
| GSE43470 | HLA-DQB2 | 3120 | 6 | 3 | 34 | |
| GSE46452 | HLA-DQB2 | 3120 | 2 | 10 | 47 | |
| GSE47630 | HLA-DQB2 | 3120 | 7 | 5 | 28 | |
| GSE54993 | HLA-DQB2 | 3120 | 3 | 1 | 66 | |
| GSE54994 | HLA-DQB2 | 3120 | 11 | 4 | 38 | |
| GSE60625 | HLA-DQB2 | 3120 | 1 | 0 | 10 | |
| GSE74703 | HLA-DQB2 | 3120 | 5 | 2 | 29 | |
| GSE74704 | HLA-DQB2 | 3120 | 3 | 0 | 17 |
Total number of gains: 52; Total number of losses: 25; Total Number of normals: 315.
Somatic mutations of HLA-DQB2:
Generating mutation plots.
Highly correlated genes for HLA-DQB2:
Showing top 20/1222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DQB2 | HLA-DRB5 | 0.828422 | 3 | 0 | 3 |
| HLA-DQB2 | CD207 | 0.764467 | 9 | 0 | 8 |
| HLA-DQB2 | HCG22 | 0.740782 | 4 | 0 | 4 |
| HLA-DQB2 | SFTA2 | 0.738412 | 4 | 0 | 4 |
| HLA-DQB2 | BRK1 | 0.737127 | 5 | 0 | 5 |
| HLA-DQB2 | KRT78 | 0.734925 | 4 | 0 | 4 |
| HLA-DQB2 | LEPROT | 0.734291 | 3 | 0 | 3 |
| HLA-DQB2 | ST6GALNAC1 | 0.726722 | 4 | 0 | 4 |
| HLA-DQB2 | IRAK2 | 0.725575 | 3 | 0 | 3 |
| HLA-DQB2 | ST3GAL3 | 0.72445 | 4 | 0 | 4 |
| HLA-DQB2 | ZNF709 | 0.723593 | 3 | 0 | 3 |
| HLA-DQB2 | SYAP1 | 0.722296 | 4 | 0 | 4 |
| HLA-DQB2 | FAM3D | 0.720214 | 4 | 0 | 4 |
| HLA-DQB2 | MMEL1 | 0.719336 | 4 | 0 | 4 |
| HLA-DQB2 | ATP13A4 | 0.717045 | 3 | 0 | 3 |
| HLA-DQB2 | VSIG2 | 0.716676 | 4 | 0 | 4 |
| HLA-DQB2 | BNIPL | 0.716489 | 4 | 0 | 4 |
| HLA-DQB2 | FAM214A | 0.715415 | 4 | 0 | 4 |
| HLA-DQB2 | A2ML1 | 0.71282 | 4 | 0 | 4 |
| HLA-DQB2 | TPRN | 0.710993 | 3 | 0 | 3 |
For details and further investigation, click here
