| Full name: major histocompatibility complex, class II, DQ beta 1 | Alias Symbol: IDDM1|CELIAC1 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3119 | HGNC ID: HGNC:4944 | Ensembl Gene: ENSG00000179344 | OMIM ID: 604305 |
| Drug and gene relationship at DGIdb | |||
HLA-DQB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DQB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DQB1 | 3119 | 212998_x_at | -0.0768 | 0.9789 | |
| GSE20347 | HLA-DQB1 | 3119 | 211654_x_at | -0.2721 | 0.4809 | |
| GSE23400 | HLA-DQB1 | 3119 | 211656_x_at | 0.2184 | 0.2069 | |
| GSE26886 | HLA-DQB1 | 3119 | 211654_x_at | -0.8723 | 0.0761 | |
| GSE29001 | HLA-DQB1 | 3119 | 211656_x_at | 0.2454 | 0.6220 | |
| GSE38129 | HLA-DQB1 | 3119 | 212998_x_at | -0.3340 | 0.3625 | |
| GSE45670 | HLA-DQB1 | 3119 | 211656_x_at | -0.4308 | 0.2191 | |
| GSE53622 | HLA-DQB1 | 3119 | 96259 | 0.1285 | 0.2430 | |
| GSE53624 | HLA-DQB1 | 3119 | 96259 | -0.1131 | 0.2472 | |
| GSE63941 | HLA-DQB1 | 3119 | 211656_x_at | 0.8453 | 0.2882 | |
| GSE77861 | HLA-DQB1 | 3119 | 211654_x_at | -0.1965 | 0.4683 | |
| GSE97050 | HLA-DQB1 | 3119 | A_33_P3424222 | 0.7557 | 0.2197 | |
| SRP007169 | HLA-DQB1 | 3119 | RNAseq | -0.3706 | 0.5451 | |
| SRP008496 | HLA-DQB1 | 3119 | RNAseq | -0.0032 | 0.9946 | |
| SRP064894 | HLA-DQB1 | 3119 | RNAseq | 0.5008 | 0.1799 | |
| SRP133303 | HLA-DQB1 | 3119 | RNAseq | -0.0405 | 0.9353 | |
| SRP159526 | HLA-DQB1 | 3119 | RNAseq | -0.2993 | 0.7682 | |
| SRP193095 | HLA-DQB1 | 3119 | RNAseq | -0.3255 | 0.3252 | |
| SRP219564 | HLA-DQB1 | 3119 | RNAseq | 1.4299 | 0.0474 | |
| TCGA | HLA-DQB1 | 3119 | RNAseq | 0.2421 | 0.1532 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HLA-DQB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DQB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DQB1 | 3119 | 7 | 0 | 23 | |
| GSE20123 | HLA-DQB1 | 3119 | 7 | 0 | 23 | |
| GSE43470 | HLA-DQB1 | 3119 | 7 | 2 | 34 | |
| GSE46452 | HLA-DQB1 | 3119 | 1 | 10 | 48 | |
| GSE47630 | HLA-DQB1 | 3119 | 7 | 5 | 28 | |
| GSE54993 | HLA-DQB1 | 3119 | 3 | 2 | 65 | |
| GSE54994 | HLA-DQB1 | 3119 | 11 | 4 | 38 | |
| GSE60625 | HLA-DQB1 | 3119 | 1 | 0 | 10 | |
| GSE74703 | HLA-DQB1 | 3119 | 6 | 1 | 29 | |
| GSE74704 | HLA-DQB1 | 3119 | 3 | 0 | 17 |
Total number of gains: 53; Total number of losses: 24; Total Number of normals: 315.
Somatic mutations of HLA-DQB1:
Generating mutation plots.
Highly correlated genes for HLA-DQB1:
Showing top 20/348 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DQB1 | HLA-DRA | 0.834083 | 13 | 0 | 13 |
| HLA-DQB1 | HLA-DRB5 | 0.77651 | 3 | 0 | 3 |
| HLA-DQB1 | HLA-DMA | 0.772627 | 13 | 0 | 13 |
| HLA-DQB1 | HLA-DMB | 0.753641 | 13 | 0 | 13 |
| HLA-DQB1 | CD74 | 0.747606 | 13 | 0 | 12 |
| HLA-DQB1 | HLA-DPB1 | 0.742911 | 13 | 0 | 12 |
| HLA-DQB1 | HLA-DPA1 | 0.730106 | 13 | 0 | 12 |
| HLA-DQB1 | FBXL14 | 0.721006 | 3 | 0 | 3 |
| HLA-DQB1 | ITGB2 | 0.711681 | 10 | 0 | 10 |
| HLA-DQB1 | CARD16 | 0.703933 | 3 | 0 | 3 |
| HLA-DQB1 | DOCK10 | 0.683168 | 9 | 0 | 8 |
| HLA-DQB1 | MS4A6A | 0.682519 | 10 | 0 | 8 |
| HLA-DQB1 | C1QC | 0.682084 | 7 | 0 | 7 |
| HLA-DQB1 | CNOT1 | 0.682025 | 3 | 0 | 3 |
| HLA-DQB1 | FBL | 0.681668 | 4 | 0 | 4 |
| HLA-DQB1 | MPEG1 | 0.681572 | 7 | 0 | 6 |
| HLA-DQB1 | PDIA6 | 0.678962 | 3 | 0 | 3 |
| HLA-DQB1 | HLA-DQA1 | 0.678265 | 10 | 0 | 7 |
| HLA-DQB1 | ZNF468 | 0.676451 | 3 | 0 | 3 |
| HLA-DQB1 | C1orf162 | 0.676271 | 7 | 0 | 6 |
For details and further investigation, click here
