ITGB2

 

Full name: integrin subunit beta 2 Alias Symbol: LFA-1|MAC-1
Type: protein-coding gene Cytoband: 21q22.3
Entrez ID: 3689 HGNC ID: HGNC:6155 Ensembl Gene: ENSG00000160255 OMIM ID: 600065
Drug and gene relationship at DGIdb

 

ITGB2 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04390Hippo signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05140Leishmaniasis
hsa05152Tuberculosis

 

Expression of ITGB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITGB2 3689 202803_s_at 0.7508 0.5909
GSE20347 ITGB2 3689 202803_s_at 0.1267 0.6146
GSE23400 ITGB2 3689 202803_s_at 0.4511 0.0001
GSE26886 ITGB2 3689 202803_s_at -0.1589 0.7528
GSE29001 ITGB2 3689 202803_s_at 0.3740 0.1445
GSE38129 ITGB2 3689 202803_s_at 0.3139 0.2752
GSE45670 ITGB2 3689 202803_s_at 0.1075 0.7620
GSE53622 ITGB2 3689 15347 0.5315 0.0003
GSE53624 ITGB2 3689 96687 0.5693 0.0000
GSE63941 ITGB2 3689 236988_x_at 0.1294 0.3810
GSE77861 ITGB2 3689 236988_x_at 0.0080 0.9736
GSE97050 ITGB2 3689 A_23_P430411 1.1869 0.0782
SRP007169 ITGB2 3689 RNAseq 2.9028 0.0012
SRP008496 ITGB2 3689 RNAseq 0.3135 0.3989
SRP064894 ITGB2 3689 RNAseq 1.6083 0.0000
SRP133303 ITGB2 3689 RNAseq 0.6488 0.0079
SRP159526 ITGB2 3689 RNAseq 0.2953 0.6887
SRP193095 ITGB2 3689 RNAseq 0.6047 0.0035
SRP219564 ITGB2 3689 RNAseq 1.4224 0.0199
TCGA ITGB2 3689 RNAseq 0.3768 0.0014

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by ITGB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITGB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITGB2 3689 2 9 19
GSE20123 ITGB2 3689 2 9 19
GSE43470 ITGB2 3689 0 13 30
GSE46452 ITGB2 3689 1 21 37
GSE47630 ITGB2 3689 6 17 17
GSE54993 ITGB2 3689 8 1 61
GSE54994 ITGB2 3689 4 8 41
GSE60625 ITGB2 3689 0 0 11
GSE74703 ITGB2 3689 0 10 26
GSE74704 ITGB2 3689 1 5 14
TCGA ITGB2 3689 9 38 49

Total number of gains: 33; Total number of losses: 131; Total Number of normals: 324.  

 

Somatic mutations of ITGB2:

 

Generating mutation plots.

 

Highly correlated genes for ITGB2:

 

Showing top 20/557 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITGB2CD530.831958909
ITGB2TYROBP0.81517911011
ITGB2FCER1G0.80562110010
ITGB2LAPTM50.80370312011
ITGB2C1QC0.7821707
ITGB2AIF10.77474911011
ITGB2GRAPL0.758586303
ITGB2DERL30.756583303
ITGB2CYBB0.75468611011
ITGB2HAVCR20.75233605
ITGB2C1QA0.75212811011
ITGB2TFEC0.74919611010
ITGB2NCKAP1L0.7490921009
ITGB2FCGR3A0.747457303
ITGB2ITGB2-AS10.744815404
ITGB2C1QB0.74356911011
ITGB2PLEK0.743132505
ITGB2LCP20.735281009
ITGB2RASSF40.729635606
ITGB2TNFRSF1B0.72927512011

For details and further investigation, click here