| Full name: allograft inflammatory factor 1 | Alias Symbol: IRT-1|AIF-1|Em:AF129756.17|IBA1 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 199 | HGNC ID: HGNC:352 | Ensembl Gene: ENSG00000204472 | OMIM ID: 601833 |
| Drug and gene relationship at DGIdb | |||
Expression of AIF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AIF1 | 199 | 215051_x_at | 0.2389 | 0.7770 | |
| GSE20347 | AIF1 | 199 | 215051_x_at | 0.0961 | 0.5024 | |
| GSE23400 | AIF1 | 199 | 215051_x_at | 0.0127 | 0.8398 | |
| GSE26886 | AIF1 | 199 | 215051_x_at | -0.0978 | 0.7850 | |
| GSE29001 | AIF1 | 199 | 215051_x_at | 0.1295 | 0.6731 | |
| GSE38129 | AIF1 | 199 | 215051_x_at | 0.0694 | 0.7257 | |
| GSE45670 | AIF1 | 199 | 215051_x_at | -0.1256 | 0.6028 | |
| GSE53622 | AIF1 | 199 | 102709 | 0.2428 | 0.0490 | |
| GSE53624 | AIF1 | 199 | 102709 | 0.2567 | 0.0253 | |
| GSE63941 | AIF1 | 199 | 213095_x_at | 0.6049 | 0.0069 | |
| GSE77861 | AIF1 | 199 | 215051_x_at | -0.0188 | 0.9308 | |
| GSE97050 | AIF1 | 199 | A_23_P214627 | 0.5527 | 0.2289 | |
| SRP007169 | AIF1 | 199 | RNAseq | 1.6074 | 0.0270 | |
| SRP008496 | AIF1 | 199 | RNAseq | 1.0152 | 0.0454 | |
| SRP064894 | AIF1 | 199 | RNAseq | 1.3091 | 0.0008 | |
| SRP133303 | AIF1 | 199 | RNAseq | 0.6100 | 0.0506 | |
| SRP159526 | AIF1 | 199 | RNAseq | 0.2302 | 0.6895 | |
| SRP193095 | AIF1 | 199 | RNAseq | 0.1614 | 0.4571 | |
| SRP219564 | AIF1 | 199 | RNAseq | 1.4393 | 0.0383 | |
| TCGA | AIF1 | 199 | RNAseq | 0.4055 | 0.0042 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by AIF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AIF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AIF1 | 199 | 5 | 1 | 24 | |
| GSE20123 | AIF1 | 199 | 5 | 1 | 24 | |
| GSE43470 | AIF1 | 199 | 5 | 3 | 35 | |
| GSE46452 | AIF1 | 199 | 1 | 10 | 48 | |
| GSE47630 | AIF1 | 199 | 7 | 4 | 29 | |
| GSE54993 | AIF1 | 199 | 2 | 1 | 67 | |
| GSE54994 | AIF1 | 199 | 11 | 4 | 38 | |
| GSE60625 | AIF1 | 199 | 0 | 1 | 10 | |
| GSE74703 | AIF1 | 199 | 5 | 1 | 30 | |
| GSE74704 | AIF1 | 199 | 2 | 0 | 18 | |
| TCGA | AIF1 | 199 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 42; Total Number of normals: 387.
Somatic mutations of AIF1:
Generating mutation plots.
Highly correlated genes for AIF1:
Showing top 20/386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AIF1 | CSF1R | 0.797017 | 12 | 0 | 12 |
| AIF1 | HCST | 0.783851 | 7 | 0 | 7 |
| AIF1 | TYROBP | 0.783758 | 12 | 0 | 12 |
| AIF1 | C1QC | 0.780979 | 8 | 0 | 8 |
| AIF1 | MPEG1 | 0.778928 | 7 | 0 | 7 |
| AIF1 | ITGB2 | 0.774749 | 11 | 0 | 11 |
| AIF1 | GMFG | 0.75749 | 11 | 0 | 11 |
| AIF1 | C1QA | 0.751392 | 12 | 0 | 11 |
| AIF1 | C1QB | 0.743711 | 12 | 0 | 12 |
| AIF1 | SIGLEC10 | 0.73228 | 6 | 0 | 6 |
| AIF1 | HLA-DMB | 0.732169 | 11 | 0 | 11 |
| AIF1 | C1orf162 | 0.725922 | 8 | 0 | 7 |
| AIF1 | CD14 | 0.722529 | 11 | 0 | 11 |
| AIF1 | FCER1G | 0.721686 | 11 | 0 | 10 |
| AIF1 | CYBB | 0.718142 | 13 | 0 | 11 |
| AIF1 | GPR34 | 0.717045 | 8 | 0 | 7 |
| AIF1 | PSMB8-AS1 | 0.716354 | 4 | 0 | 4 |
| AIF1 | PIK3CG | 0.707612 | 8 | 0 | 7 |
| AIF1 | CR1 | 0.706571 | 4 | 0 | 4 |
| AIF1 | MFNG | 0.706405 | 5 | 0 | 5 |
For details and further investigation, click here
