| Full name: major histocompatibility complex, class II, DM alpha | Alias Symbol: D6S222E|RING6 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3108 | HGNC ID: HGNC:4934 | Ensembl Gene: ENSG00000204257 | OMIM ID: 142855 |
| Drug and gene relationship at DGIdb | |||
HLA-DMA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DMA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DMA | 3108 | 217478_s_at | 0.0300 | 0.9874 | |
| GSE20347 | HLA-DMA | 3108 | 217478_s_at | -0.0966 | 0.8502 | |
| GSE23400 | HLA-DMA | 3108 | 217478_s_at | 0.1856 | 0.3669 | |
| GSE26886 | HLA-DMA | 3108 | 217478_s_at | -0.3701 | 0.4992 | |
| GSE29001 | HLA-DMA | 3108 | 217478_s_at | 0.3358 | 0.4395 | |
| GSE38129 | HLA-DMA | 3108 | 217478_s_at | -0.2356 | 0.5723 | |
| GSE45670 | HLA-DMA | 3108 | 217478_s_at | -0.1237 | 0.8587 | |
| GSE53622 | HLA-DMA | 3108 | 107981 | 0.0458 | 0.7829 | |
| GSE53624 | HLA-DMA | 3108 | 107981 | -0.2636 | 0.1173 | |
| GSE63941 | HLA-DMA | 3108 | 217478_s_at | -0.6326 | 0.6703 | |
| GSE77861 | HLA-DMA | 3108 | 217478_s_at | -0.3256 | 0.4778 | |
| GSE97050 | HLA-DMA | 3108 | A_24_P50245 | 0.6008 | 0.2727 | |
| SRP007169 | HLA-DMA | 3108 | RNAseq | 1.0078 | 0.1539 | |
| SRP008496 | HLA-DMA | 3108 | RNAseq | 0.5436 | 0.1971 | |
| SRP064894 | HLA-DMA | 3108 | RNAseq | 0.6032 | 0.0566 | |
| SRP133303 | HLA-DMA | 3108 | RNAseq | -0.0038 | 0.9864 | |
| SRP159526 | HLA-DMA | 3108 | RNAseq | -0.6473 | 0.3514 | |
| SRP193095 | HLA-DMA | 3108 | RNAseq | 0.0160 | 0.9534 | |
| SRP219564 | HLA-DMA | 3108 | RNAseq | 0.9950 | 0.0160 | |
| TCGA | HLA-DMA | 3108 | RNAseq | -0.0096 | 0.9415 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HLA-DMA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DMA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DMA | 3108 | 5 | 0 | 25 | |
| GSE20123 | HLA-DMA | 3108 | 5 | 0 | 25 | |
| GSE43470 | HLA-DMA | 3108 | 5 | 1 | 37 | |
| GSE46452 | HLA-DMA | 3108 | 2 | 9 | 48 | |
| GSE47630 | HLA-DMA | 3108 | 8 | 4 | 28 | |
| GSE54993 | HLA-DMA | 3108 | 3 | 1 | 66 | |
| GSE54994 | HLA-DMA | 3108 | 11 | 4 | 38 | |
| GSE60625 | HLA-DMA | 3108 | 1 | 0 | 10 | |
| GSE74703 | HLA-DMA | 3108 | 5 | 0 | 31 | |
| GSE74704 | HLA-DMA | 3108 | 2 | 0 | 18 |
Total number of gains: 47; Total number of losses: 19; Total Number of normals: 326.
Somatic mutations of HLA-DMA:
Generating mutation plots.
Highly correlated genes for HLA-DMA:
Showing top 20/465 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DMA | HLA-DMB | 0.882053 | 12 | 0 | 12 |
| HLA-DMA | CD74 | 0.853896 | 13 | 0 | 12 |
| HLA-DMA | HLA-DRA | 0.852657 | 13 | 0 | 13 |
| HLA-DMA | HLA-DPA1 | 0.807474 | 12 | 0 | 12 |
| HLA-DMA | HLA-DPB1 | 0.802846 | 13 | 0 | 13 |
| HLA-DMA | HLA-DQB1 | 0.772627 | 13 | 0 | 13 |
| HLA-DMA | SLAMF6 | 0.767196 | 5 | 0 | 5 |
| HLA-DMA | C1orf162 | 0.741053 | 7 | 0 | 6 |
| HLA-DMA | LAPTM5 | 0.739407 | 12 | 0 | 11 |
| HLA-DMA | HLA-DQA2 | 0.729558 | 3 | 0 | 3 |
| HLA-DMA | GIMAP5 | 0.727831 | 4 | 0 | 4 |
| HLA-DMA | PIK3AP1 | 0.724461 | 4 | 0 | 4 |
| HLA-DMA | CD84 | 0.722884 | 9 | 0 | 7 |
| HLA-DMA | PIK3R6 | 0.7212 | 4 | 0 | 4 |
| HLA-DMA | MS4A6A | 0.717116 | 11 | 0 | 11 |
| HLA-DMA | RASAL3 | 0.713291 | 5 | 0 | 5 |
| HLA-DMA | MPEG1 | 0.71181 | 7 | 0 | 7 |
| HLA-DMA | CERKL | 0.70954 | 3 | 0 | 3 |
| HLA-DMA | HLA-DQA1 | 0.707345 | 9 | 0 | 6 |
| HLA-DMA | CD53 | 0.705753 | 10 | 0 | 8 |
For details and further investigation, click here
