CYBB

 

Full name: cytochrome b-245 beta chain Alias Symbol: GP91-PHOX|NOX2
Type: protein-coding gene Cytoband: Xp21.1-p11.4
Entrez ID: 1536 HGNC ID: HGNC:2578 Ensembl Gene: ENSG00000165168 OMIM ID: 300481
Drug and gene relationship at DGIdb

 

CYBB involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway
hsa04380Osteoclast differentiation
hsa04670Leukocyte transendothelial migration
hsa04933AGE-RAGE signaling pathway in diabetic complications

 

Expression of CYBB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CYBB 1536 203923_s_at 0.2714 0.8356
GSE20347 CYBB 1536 203922_s_at 0.1373 0.2737
GSE23400 CYBB 1536 203922_s_at 0.0825 0.1894
GSE26886 CYBB 1536 203923_s_at -0.4022 0.0635
GSE29001 CYBB 1536 203923_s_at 0.5322 0.0403
GSE38129 CYBB 1536 203923_s_at 0.3994 0.2744
GSE45670 CYBB 1536 203923_s_at -0.2874 0.4849
GSE53622 CYBB 1536 30492 0.2410 0.1988
GSE53624 CYBB 1536 30492 0.3958 0.0173
GSE63941 CYBB 1536 233538_s_at 1.2294 0.0012
GSE77861 CYBB 1536 203923_s_at 0.1628 0.4164
GSE97050 CYBB 1536 A_24_P365767 0.7270 0.2444
SRP007169 CYBB 1536 RNAseq 2.5440 0.0004
SRP008496 CYBB 1536 RNAseq 1.7833 0.0002
SRP064894 CYBB 1536 RNAseq 1.2725 0.0007
SRP133303 CYBB 1536 RNAseq 0.8523 0.0136
SRP159526 CYBB 1536 RNAseq 0.3552 0.7000
SRP193095 CYBB 1536 RNAseq 0.7378 0.0005
SRP219564 CYBB 1536 RNAseq 1.6138 0.0261
TCGA CYBB 1536 RNAseq 0.1580 0.2311

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by CYBB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CYBB:

 

No record found for this gene.

 

Somatic mutations of CYBB:

 

Generating mutation plots.

 

Highly correlated genes for CYBB:

 

Showing top 20/414 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CYBBMPEG10.846943606
CYBBMS4A70.782414404
CYBBHCST0.768437606
CYBBFPR30.755772908
CYBBITGB20.75468611011
CYBBMS4A4A0.74851511010
CYBBCD1630.74848911011
CYBBC1QB0.74022211011
CYBBNCKAP1L0.740184807
CYBBCD530.73667810010
CYBBCCR10.73420211010
CYBBITGAM0.733887808
CYBBC1QA0.73039912011
CYBBRNASE60.728549909
CYBBLAPTM50.72742712011
CYBBGIMAP20.726029808
CYBBSNX200.724867606
CYBBTYROBP0.72026712010
CYBBAIF10.71814213011
CYBBSIGLEC100.716896606

For details and further investigation, click here