KCNK4

 

Full name: potassium two pore domain channel subfamily K member 4 Alias Symbol: K2p4.1|TRAAK
Type: protein-coding gene Cytoband: 11q13.1
Entrez ID: 50801 HGNC ID: HGNC:6279 Ensembl Gene: ENSG00000182450 OMIM ID: 605720
Drug and gene relationship at DGIdb

 

Expression of KCNK4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KCNK4 50801 224552_s_at -0.0894 0.8018
GSE26886 KCNK4 50801 224552_s_at 0.1286 0.2317
GSE45670 KCNK4 50801 224552_s_at -0.0383 0.6600
GSE63941 KCNK4 50801 224552_s_at 0.0447 0.7569
GSE77861 KCNK4 50801 224552_s_at -0.0463 0.7514
TCGA KCNK4 50801 RNAseq 0.4693 0.4850

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by KCNK4 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of KCNK4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KCNK4 50801 6 5 19
GSE20123 KCNK4 50801 6 5 19
GSE43470 KCNK4 50801 1 3 39
GSE46452 KCNK4 50801 8 4 47
GSE47630 KCNK4 50801 4 6 30
GSE54993 KCNK4 50801 3 0 67
GSE54994 KCNK4 50801 5 5 43
GSE60625 KCNK4 50801 0 4 7
GSE74703 KCNK4 50801 1 1 34
GSE74704 KCNK4 50801 4 3 13
TCGA KCNK4 50801 20 9 67

Total number of gains: 58; Total number of losses: 45; Total Number of normals: 385.  

 

Somatic mutations of KCNK4:

 

Generating mutation plots.

 

Highly correlated genes for KCNK4:

 

Showing all 12 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KCNK4GZMM0.618629303
KCNK4HDAC110.613502303
KCNK4COL25A10.601632303
KCNK4NPAS10.591072303
KCNK4ZNF6960.588434303
KCNK4SLC22A18AS0.576264503
KCNK4SLC6A170.571094303
KCNK4ADCY100.558798303
KCNK4MYBPC30.548104303
KCNK4SLC11A10.522493303
KCNK4MYL40.522318403
KCNK4NOXO10.510784403

For details and further investigation, click here