| Full name: adenylate cyclase 10 | Alias Symbol: SAC|Sacy|SACI|HCA2|RP1-313L4.2 | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 55811 | HGNC ID: HGNC:21285 | Ensembl Gene: ENSG00000143199 | OMIM ID: 605205 |
| Drug and gene relationship at DGIdb | |||
ADCY10 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04713 | Circadian entrainment |
Expression of ADCY10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADCY10 | 55811 | 217305_s_at | 0.0502 | 0.8856 | |
| GSE20347 | ADCY10 | 55811 | 217305_s_at | 0.1560 | 0.1209 | |
| GSE23400 | ADCY10 | 55811 | 217305_s_at | 0.0199 | 0.6784 | |
| GSE26886 | ADCY10 | 55811 | 217305_s_at | 0.5007 | 0.0831 | |
| GSE29001 | ADCY10 | 55811 | 214547_at | 0.2585 | 0.3161 | |
| GSE38129 | ADCY10 | 55811 | 217305_s_at | 0.2582 | 0.0220 | |
| GSE45670 | ADCY10 | 55811 | 217305_s_at | 0.1633 | 0.1708 | |
| GSE53622 | ADCY10 | 55811 | 21685 | 0.9734 | 0.0000 | |
| GSE53624 | ADCY10 | 55811 | 21685 | 1.7051 | 0.0000 | |
| GSE63941 | ADCY10 | 55811 | 217305_s_at | 0.3826 | 0.5532 | |
| GSE77861 | ADCY10 | 55811 | 217305_s_at | -0.0259 | 0.7998 | |
| GSE97050 | ADCY10 | 55811 | A_23_P126313 | 0.0259 | 0.9188 | |
| SRP133303 | ADCY10 | 55811 | RNAseq | 0.7320 | 0.0289 | |
| TCGA | ADCY10 | 55811 | RNAseq | 0.6431 | 0.3130 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ADCY10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADCY10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADCY10 | 55811 | 11 | 1 | 18 | |
| GSE20123 | ADCY10 | 55811 | 11 | 1 | 18 | |
| GSE43470 | ADCY10 | 55811 | 7 | 2 | 34 | |
| GSE46452 | ADCY10 | 55811 | 3 | 1 | 55 | |
| GSE47630 | ADCY10 | 55811 | 14 | 0 | 26 | |
| GSE54993 | ADCY10 | 55811 | 0 | 6 | 64 | |
| GSE54994 | ADCY10 | 55811 | 16 | 0 | 37 | |
| GSE60625 | ADCY10 | 55811 | 0 | 0 | 11 | |
| GSE74703 | ADCY10 | 55811 | 7 | 2 | 27 | |
| GSE74704 | ADCY10 | 55811 | 5 | 0 | 15 | |
| TCGA | ADCY10 | 55811 | 44 | 3 | 49 |
Total number of gains: 118; Total number of losses: 16; Total Number of normals: 354.
Somatic mutations of ADCY10:
Generating mutation plots.
Highly correlated genes for ADCY10:
Showing top 20/47 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADCY10 | NDP | 0.657537 | 3 | 0 | 3 |
| ADCY10 | DLX6-AS1 | 0.615585 | 4 | 0 | 3 |
| ADCY10 | KCNQ1DN | 0.614365 | 3 | 0 | 3 |
| ADCY10 | ARHGEF17 | 0.600904 | 3 | 0 | 3 |
| ADCY10 | DLGAP1-AS2 | 0.596694 | 4 | 0 | 3 |
| ADCY10 | HS1BP3 | 0.587391 | 4 | 0 | 3 |
| ADCY10 | SCN9A | 0.580759 | 6 | 0 | 4 |
| ADCY10 | TMEM158 | 0.577466 | 4 | 0 | 3 |
| ADCY10 | RCCD1 | 0.573127 | 4 | 0 | 3 |
| ADCY10 | CYP4F11 | 0.567391 | 4 | 0 | 3 |
| ADCY10 | DYRK4 | 0.565659 | 3 | 0 | 3 |
| ADCY10 | FBN2 | 0.565407 | 6 | 0 | 5 |
| ADCY10 | LHX2 | 0.564615 | 5 | 0 | 4 |
| ADCY10 | SLCO1A2 | 0.563551 | 4 | 0 | 3 |
| ADCY10 | WNT2 | 0.559522 | 4 | 0 | 3 |
| ADCY10 | KCNK4 | 0.558798 | 3 | 0 | 3 |
| ADCY10 | HSD17B2 | 0.558221 | 3 | 0 | 3 |
| ADCY10 | NIPSNAP1 | 0.556122 | 6 | 0 | 5 |
| ADCY10 | VWA8-AS1 | 0.552107 | 4 | 0 | 3 |
| ADCY10 | PRAME | 0.549996 | 6 | 0 | 4 |
For details and further investigation, click here
