| Full name: myosin binding protein C, cardiac | Alias Symbol: MYBP-C|FHC|cMyBP-C | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 4607 | HGNC ID: HGNC:7551 | Ensembl Gene: ENSG00000134571 | OMIM ID: 600958 |
| Drug and gene relationship at DGIdb | |||
Expression of MYBPC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYBPC3 | 4607 | 208040_s_at | -0.1744 | 0.3483 | |
| GSE20347 | MYBPC3 | 4607 | 208040_s_at | -0.1393 | 0.1148 | |
| GSE23400 | MYBPC3 | 4607 | 208040_s_at | -0.2208 | 0.0000 | |
| GSE26886 | MYBPC3 | 4607 | 208040_s_at | 0.1984 | 0.1133 | |
| GSE29001 | MYBPC3 | 4607 | 208040_s_at | -0.2520 | 0.1666 | |
| GSE38129 | MYBPC3 | 4607 | 208040_s_at | -0.1944 | 0.0144 | |
| GSE45670 | MYBPC3 | 4607 | 208040_s_at | -0.0447 | 0.6058 | |
| GSE53622 | MYBPC3 | 4607 | 55002 | 0.1740 | 0.0519 | |
| GSE53624 | MYBPC3 | 4607 | 55002 | 0.0398 | 0.7530 | |
| GSE63941 | MYBPC3 | 4607 | 208040_s_at | 0.2515 | 0.1456 | |
| GSE77861 | MYBPC3 | 4607 | 208040_s_at | -0.1700 | 0.3191 | |
| SRP219564 | MYBPC3 | 4607 | RNAseq | 0.2163 | 0.6598 | |
| TCGA | MYBPC3 | 4607 | RNAseq | -4.8151 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MYBPC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYBPC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYBPC3 | 4607 | 3 | 7 | 20 | |
| GSE20123 | MYBPC3 | 4607 | 3 | 6 | 21 | |
| GSE43470 | MYBPC3 | 4607 | 1 | 4 | 38 | |
| GSE46452 | MYBPC3 | 4607 | 8 | 5 | 46 | |
| GSE47630 | MYBPC3 | 4607 | 3 | 9 | 28 | |
| GSE54993 | MYBPC3 | 4607 | 3 | 0 | 67 | |
| GSE54994 | MYBPC3 | 4607 | 1 | 11 | 41 | |
| GSE60625 | MYBPC3 | 4607 | 0 | 0 | 11 | |
| GSE74703 | MYBPC3 | 4607 | 1 | 2 | 33 | |
| GSE74704 | MYBPC3 | 4607 | 2 | 4 | 14 | |
| TCGA | MYBPC3 | 4607 | 10 | 20 | 66 |
Total number of gains: 35; Total number of losses: 68; Total Number of normals: 385.
Somatic mutations of MYBPC3:
Generating mutation plots.
Highly correlated genes for MYBPC3:
Showing top 20/1228 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYBPC3 | GPR61 | 0.792797 | 3 | 0 | 3 |
| MYBPC3 | MAPK11 | 0.763575 | 3 | 0 | 3 |
| MYBPC3 | GDF10 | 0.723285 | 3 | 0 | 3 |
| MYBPC3 | AMN | 0.721293 | 6 | 0 | 6 |
| MYBPC3 | OR7C2 | 0.710279 | 4 | 0 | 4 |
| MYBPC3 | PNPLA7 | 0.709703 | 4 | 0 | 4 |
| MYBPC3 | CCDC9 | 0.708995 | 5 | 0 | 5 |
| MYBPC3 | CIB3 | 0.707495 | 3 | 0 | 3 |
| MYBPC3 | LIPF | 0.70688 | 3 | 0 | 3 |
| MYBPC3 | AMELX | 0.704566 | 4 | 0 | 4 |
| MYBPC3 | ST8SIA3 | 0.70403 | 4 | 0 | 4 |
| MYBPC3 | RASL10B | 0.698211 | 4 | 0 | 4 |
| MYBPC3 | IGH | 0.697775 | 7 | 0 | 7 |
| MYBPC3 | LUZP4 | 0.697406 | 3 | 0 | 3 |
| MYBPC3 | NTNG1 | 0.697302 | 3 | 0 | 3 |
| MYBPC3 | CDH24 | 0.696778 | 3 | 0 | 3 |
| MYBPC3 | GRIN2D | 0.68948 | 3 | 0 | 3 |
| MYBPC3 | TMEM114 | 0.685866 | 3 | 0 | 3 |
| MYBPC3 | CHST4 | 0.684119 | 4 | 0 | 4 |
| MYBPC3 | LINC00486 | 0.683193 | 3 | 0 | 3 |
For details and further investigation, click here
