| Full name: myosin light chain 4 | Alias Symbol: ALC1|AMLC|GT1|PRO1957 | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 4635 | HGNC ID: HGNC:7585 | Ensembl Gene: ENSG00000198336 | OMIM ID: 160770 |
| Drug and gene relationship at DGIdb | |||
MYL4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of MYL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYL4 | 4635 | 210395_x_at | -0.2488 | 0.1553 | |
| GSE20347 | MYL4 | 4635 | 217274_x_at | -0.1209 | 0.0747 | |
| GSE23400 | MYL4 | 4635 | 210088_x_at | -0.1787 | 0.0000 | |
| GSE26886 | MYL4 | 4635 | 217274_x_at | -0.0239 | 0.8788 | |
| GSE29001 | MYL4 | 4635 | 217274_x_at | -0.2181 | 0.0865 | |
| GSE38129 | MYL4 | 4635 | 210088_x_at | -0.2289 | 0.0049 | |
| GSE45670 | MYL4 | 4635 | 217274_x_at | 0.0720 | 0.4798 | |
| GSE53622 | MYL4 | 4635 | 15998 | -0.4033 | 0.0001 | |
| GSE53624 | MYL4 | 4635 | 15998 | -0.1226 | 0.0752 | |
| GSE63941 | MYL4 | 4635 | 210395_x_at | -0.3965 | 0.0205 | |
| GSE77861 | MYL4 | 4635 | 210088_x_at | -0.1399 | 0.1820 | |
| GSE97050 | MYL4 | 4635 | A_24_P151032 | 0.1366 | 0.4804 | |
| TCGA | MYL4 | 4635 | RNAseq | -4.0185 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MYL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYL4 | 4635 | 5 | 2 | 23 | |
| GSE20123 | MYL4 | 4635 | 5 | 2 | 23 | |
| GSE43470 | MYL4 | 4635 | 1 | 2 | 40 | |
| GSE46452 | MYL4 | 4635 | 32 | 0 | 27 | |
| GSE47630 | MYL4 | 4635 | 9 | 0 | 31 | |
| GSE54993 | MYL4 | 4635 | 2 | 4 | 64 | |
| GSE54994 | MYL4 | 4635 | 11 | 5 | 37 | |
| GSE60625 | MYL4 | 4635 | 4 | 0 | 7 | |
| GSE74703 | MYL4 | 4635 | 1 | 1 | 34 | |
| GSE74704 | MYL4 | 4635 | 4 | 1 | 15 | |
| TCGA | MYL4 | 4635 | 26 | 6 | 64 |
Total number of gains: 100; Total number of losses: 23; Total Number of normals: 365.
Somatic mutations of MYL4:
Generating mutation plots.
Highly correlated genes for MYL4:
Showing top 20/684 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYL4 | BSND | 0.794965 | 3 | 0 | 3 |
| MYL4 | CELF4 | 0.7887 | 3 | 0 | 3 |
| MYL4 | C16orf89 | 0.763537 | 3 | 0 | 3 |
| MYL4 | FAM71A | 0.754295 | 3 | 0 | 3 |
| MYL4 | FAM171A2 | 0.751611 | 3 | 0 | 3 |
| MYL4 | ZNF777 | 0.744064 | 3 | 0 | 3 |
| MYL4 | DOK7 | 0.738495 | 3 | 0 | 3 |
| MYL4 | LCN8 | 0.72203 | 4 | 0 | 4 |
| MYL4 | C22orf39 | 0.719969 | 3 | 0 | 3 |
| MYL4 | DCT | 0.714446 | 3 | 0 | 3 |
| MYL4 | KLHL34 | 0.713402 | 3 | 0 | 3 |
| MYL4 | MYO1A | 0.700673 | 6 | 0 | 6 |
| MYL4 | RHBG | 0.694488 | 5 | 0 | 5 |
| MYL4 | PLA2G4D | 0.691776 | 3 | 0 | 3 |
| MYL4 | DHH | 0.691033 | 4 | 0 | 4 |
| MYL4 | PRDM12 | 0.68915 | 7 | 0 | 7 |
| MYL4 | CYP2D6 | 0.686826 | 6 | 0 | 6 |
| MYL4 | CBLN4 | 0.683209 | 4 | 0 | 4 |
| MYL4 | SYPL2 | 0.679716 | 3 | 0 | 3 |
| MYL4 | MAPK8IP1 | 0.671625 | 7 | 0 | 6 |
For details and further investigation, click here
