| Full name: histone deacetylase 11 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p25.1 | ||
| Entrez ID: 79885 | HGNC ID: HGNC:19086 | Ensembl Gene: ENSG00000163517 | OMIM ID: 607226 |
| Drug and gene relationship at DGIdb | |||
Expression of HDAC11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HDAC11 | 79885 | 227679_at | 0.1643 | 0.7588 | |
| GSE20347 | HDAC11 | 79885 | 219847_at | -0.0388 | 0.6626 | |
| GSE23400 | HDAC11 | 79885 | 219847_at | -0.0855 | 0.0077 | |
| GSE26886 | HDAC11 | 79885 | 227679_at | -0.5060 | 0.0296 | |
| GSE29001 | HDAC11 | 79885 | 219847_at | -0.1284 | 0.4498 | |
| GSE38129 | HDAC11 | 79885 | 219847_at | -0.1583 | 0.0070 | |
| GSE45670 | HDAC11 | 79885 | 227679_at | -0.1973 | 0.2629 | |
| GSE53622 | HDAC11 | 79885 | 66080 | -0.6359 | 0.0000 | |
| GSE53624 | HDAC11 | 79885 | 66080 | -0.6490 | 0.0000 | |
| GSE63941 | HDAC11 | 79885 | 219847_at | 0.1828 | 0.3204 | |
| GSE77861 | HDAC11 | 79885 | 219847_at | -0.0697 | 0.6351 | |
| GSE97050 | HDAC11 | 79885 | A_33_P3417936 | -0.7356 | 0.1550 | |
| SRP007169 | HDAC11 | 79885 | RNAseq | -2.2036 | 0.0000 | |
| SRP008496 | HDAC11 | 79885 | RNAseq | -1.7198 | 0.0000 | |
| SRP064894 | HDAC11 | 79885 | RNAseq | -0.3601 | 0.2978 | |
| SRP133303 | HDAC11 | 79885 | RNAseq | -1.0371 | 0.0000 | |
| SRP159526 | HDAC11 | 79885 | RNAseq | -1.1658 | 0.0000 | |
| SRP193095 | HDAC11 | 79885 | RNAseq | -0.7752 | 0.0000 | |
| SRP219564 | HDAC11 | 79885 | RNAseq | -1.1023 | 0.0239 | |
| TCGA | HDAC11 | 79885 | RNAseq | -0.2397 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by HDAC11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HDAC11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HDAC11 | 79885 | 1 | 17 | 12 | |
| GSE20123 | HDAC11 | 79885 | 1 | 18 | 11 | |
| GSE43470 | HDAC11 | 79885 | 0 | 21 | 22 | |
| GSE46452 | HDAC11 | 79885 | 2 | 17 | 40 | |
| GSE47630 | HDAC11 | 79885 | 2 | 23 | 15 | |
| GSE54993 | HDAC11 | 79885 | 6 | 1 | 63 | |
| GSE54994 | HDAC11 | 79885 | 1 | 32 | 20 | |
| GSE60625 | HDAC11 | 79885 | 5 | 0 | 6 | |
| GSE74703 | HDAC11 | 79885 | 0 | 17 | 19 | |
| GSE74704 | HDAC11 | 79885 | 1 | 10 | 9 | |
| TCGA | HDAC11 | 79885 | 2 | 68 | 26 |
Total number of gains: 21; Total number of losses: 224; Total Number of normals: 243.
Somatic mutations of HDAC11:
Generating mutation plots.
Highly correlated genes for HDAC11:
Showing top 20/631 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HDAC11 | NUCB1 | 0.781746 | 3 | 0 | 3 |
| HDAC11 | DNAH11 | 0.769582 | 3 | 0 | 3 |
| HDAC11 | CCDC159 | 0.751375 | 3 | 0 | 3 |
| HDAC11 | NRL | 0.73979 | 4 | 0 | 4 |
| HDAC11 | CCS | 0.739093 | 3 | 0 | 3 |
| HDAC11 | PPP1R3D | 0.732238 | 3 | 0 | 3 |
| HDAC11 | RAB23 | 0.72584 | 3 | 0 | 3 |
| HDAC11 | FAM168B | 0.723054 | 3 | 0 | 3 |
| HDAC11 | EIF4ENIF1 | 0.718742 | 3 | 0 | 3 |
| HDAC11 | WDR37 | 0.7106 | 3 | 0 | 3 |
| HDAC11 | ABHD4 | 0.70869 | 3 | 0 | 3 |
| HDAC11 | RIT2 | 0.708508 | 4 | 0 | 4 |
| HDAC11 | DCP1A | 0.705733 | 4 | 0 | 3 |
| HDAC11 | ZNF814 | 0.705373 | 3 | 0 | 3 |
| HDAC11 | SLC4A5 | 0.704471 | 4 | 0 | 3 |
| HDAC11 | HHLA1 | 0.702645 | 5 | 0 | 4 |
| HDAC11 | SMO | 0.697081 | 4 | 0 | 3 |
| HDAC11 | MRPS36 | 0.694947 | 4 | 0 | 4 |
| HDAC11 | CLIP1 | 0.689949 | 4 | 0 | 4 |
| HDAC11 | MXI1 | 0.687862 | 4 | 0 | 4 |
For details and further investigation, click here
