| Full name: neuronal PAS domain protein 1 | Alias Symbol: MOP5|PASD5|bHLHe11 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 4861 | HGNC ID: HGNC:7894 | Ensembl Gene: ENSG00000130751 | OMIM ID: 603346 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NPAS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPAS1 | 4861 | 206699_x_at | 0.0898 | 0.6786 | |
| GSE20347 | NPAS1 | 4861 | 206699_x_at | -0.0485 | 0.2617 | |
| GSE23400 | NPAS1 | 4861 | 206699_x_at | -0.1021 | 0.0021 | |
| GSE26886 | NPAS1 | 4861 | 216975_x_at | 0.3673 | 0.0105 | |
| GSE29001 | NPAS1 | 4861 | 216975_x_at | -0.0556 | 0.6762 | |
| GSE38129 | NPAS1 | 4861 | 206699_x_at | -0.0539 | 0.4418 | |
| GSE45670 | NPAS1 | 4861 | 216975_x_at | -0.0298 | 0.7706 | |
| GSE53622 | NPAS1 | 4861 | 79966 | -0.0037 | 0.9611 | |
| GSE53624 | NPAS1 | 4861 | 79966 | 0.1575 | 0.0258 | |
| GSE63941 | NPAS1 | 4861 | 216975_x_at | 0.2828 | 0.2641 | |
| GSE77861 | NPAS1 | 4861 | 216975_x_at | 0.0886 | 0.5733 | |
| GSE97050 | NPAS1 | 4861 | A_23_P27734 | 0.1259 | 0.6544 | |
| SRP133303 | NPAS1 | 4861 | RNAseq | 0.7216 | 0.0663 | |
| SRP159526 | NPAS1 | 4861 | RNAseq | 1.8486 | 0.0000 | |
| SRP219564 | NPAS1 | 4861 | RNAseq | 0.3984 | 0.4570 | |
| TCGA | NPAS1 | 4861 | RNAseq | -0.2304 | 0.4166 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NPAS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPAS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPAS1 | 4861 | 4 | 4 | 22 | |
| GSE20123 | NPAS1 | 4861 | 4 | 3 | 23 | |
| GSE43470 | NPAS1 | 4861 | 3 | 11 | 29 | |
| GSE46452 | NPAS1 | 4861 | 45 | 1 | 13 | |
| GSE47630 | NPAS1 | 4861 | 8 | 7 | 25 | |
| GSE54993 | NPAS1 | 4861 | 17 | 4 | 49 | |
| GSE54994 | NPAS1 | 4861 | 4 | 14 | 35 | |
| GSE60625 | NPAS1 | 4861 | 9 | 0 | 2 | |
| GSE74703 | NPAS1 | 4861 | 3 | 7 | 26 | |
| GSE74704 | NPAS1 | 4861 | 4 | 1 | 15 | |
| TCGA | NPAS1 | 4861 | 15 | 17 | 64 |
Total number of gains: 116; Total number of losses: 69; Total Number of normals: 303.
Somatic mutations of NPAS1:
Generating mutation plots.
Highly correlated genes for NPAS1:
Showing top 20/429 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPAS1 | PRSS38 | 0.786391 | 3 | 0 | 3 |
| NPAS1 | SHISA8 | 0.781622 | 3 | 0 | 3 |
| NPAS1 | YY2 | 0.780439 | 3 | 0 | 3 |
| NPAS1 | RLN3 | 0.777084 | 3 | 0 | 3 |
| NPAS1 | C1QL2 | 0.774034 | 3 | 0 | 3 |
| NPAS1 | MRGPRG | 0.771799 | 3 | 0 | 3 |
| NPAS1 | OR2B11 | 0.768862 | 3 | 0 | 3 |
| NPAS1 | WNT9A | 0.760954 | 3 | 0 | 3 |
| NPAS1 | C19orf71 | 0.756189 | 3 | 0 | 3 |
| NPAS1 | BSX | 0.753156 | 3 | 0 | 3 |
| NPAS1 | TSPAN11 | 0.745903 | 3 | 0 | 3 |
| NPAS1 | ANKRD33B | 0.742298 | 4 | 0 | 4 |
| NPAS1 | C9orf153 | 0.735631 | 3 | 0 | 3 |
| NPAS1 | CLCNKA | 0.730264 | 3 | 0 | 3 |
| NPAS1 | RETN | 0.726454 | 5 | 0 | 5 |
| NPAS1 | TBX21 | 0.725389 | 3 | 0 | 3 |
| NPAS1 | CCDC42 | 0.725359 | 3 | 0 | 3 |
| NPAS1 | SLC39A5 | 0.715109 | 3 | 0 | 3 |
| NPAS1 | TLR9 | 0.714901 | 3 | 0 | 3 |
| NPAS1 | DNAH10OS | 0.713129 | 3 | 0 | 3 |
For details and further investigation, click here
