| Full name: kallikrein related peptidase 4 | Alias Symbol: EMSP|EMSP1|PSTS|KLK-L1 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 9622 | HGNC ID: HGNC:6365 | Ensembl Gene: ENSG00000167749 | OMIM ID: 603767 |
| Drug and gene relationship at DGIdb | |||
Expression of KLK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK4 | 9622 | 1555697_at | -0.1327 | 0.4772 | |
| GSE26886 | KLK4 | 9622 | 1555697_at | -0.4192 | 0.0223 | |
| GSE45670 | KLK4 | 9622 | 1555697_at | 0.0808 | 0.4155 | |
| GSE53622 | KLK4 | 9622 | 8940 | 0.6875 | 0.0029 | |
| GSE53624 | KLK4 | 9622 | 8940 | 0.4752 | 0.0170 | |
| GSE63941 | KLK4 | 9622 | 1555697_at | 0.1724 | 0.3394 | |
| GSE77861 | KLK4 | 9622 | 1555697_at | -0.2082 | 0.0529 | |
| GSE97050 | KLK4 | 9622 | A_24_P376047 | 0.5291 | 0.3560 | |
| SRP064894 | KLK4 | 9622 | RNAseq | -0.4882 | 0.0729 | |
| SRP133303 | KLK4 | 9622 | RNAseq | -0.1954 | 0.3983 | |
| SRP159526 | KLK4 | 9622 | RNAseq | 0.7910 | 0.1403 | |
| SRP219564 | KLK4 | 9622 | RNAseq | -0.8943 | 0.0703 | |
| TCGA | KLK4 | 9622 | RNAseq | 5.1420 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KLK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK4 | 9622 | 3 | 4 | 23 | |
| GSE20123 | KLK4 | 9622 | 3 | 3 | 24 | |
| GSE43470 | KLK4 | 9622 | 4 | 11 | 28 | |
| GSE46452 | KLK4 | 9622 | 45 | 1 | 13 | |
| GSE47630 | KLK4 | 9622 | 9 | 6 | 25 | |
| GSE54993 | KLK4 | 9622 | 17 | 4 | 49 | |
| GSE54994 | KLK4 | 9622 | 4 | 14 | 35 | |
| GSE60625 | KLK4 | 9622 | 9 | 0 | 2 | |
| GSE74703 | KLK4 | 9622 | 4 | 7 | 25 | |
| GSE74704 | KLK4 | 9622 | 3 | 1 | 16 | |
| TCGA | KLK4 | 9622 | 14 | 19 | 63 |
Total number of gains: 115; Total number of losses: 70; Total Number of normals: 303.
Somatic mutations of KLK4:
Generating mutation plots.
Highly correlated genes for KLK4:
Showing top 20/444 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK4 | CAPN13 | 0.770666 | 3 | 0 | 3 |
| KLK4 | TMC2 | 0.713956 | 3 | 0 | 3 |
| KLK4 | GAL3ST2 | 0.709664 | 3 | 0 | 3 |
| KLK4 | TTR | 0.703218 | 3 | 0 | 3 |
| KLK4 | CGREF1 | 0.697726 | 3 | 0 | 3 |
| KLK4 | DEFA5 | 0.696083 | 4 | 0 | 3 |
| KLK4 | PRB1 | 0.694652 | 3 | 0 | 3 |
| KLK4 | DLGAP3 | 0.691022 | 3 | 0 | 3 |
| KLK4 | GPR50 | 0.684644 | 4 | 0 | 4 |
| KLK4 | MAPK3 | 0.683575 | 3 | 0 | 3 |
| KLK4 | MTUS2-AS1 | 0.681033 | 3 | 0 | 3 |
| KLK4 | SLC34A3 | 0.678722 | 5 | 0 | 5 |
| KLK4 | IQCF5-AS1 | 0.667045 | 3 | 0 | 3 |
| KLK4 | CDH10 | 0.665888 | 3 | 0 | 3 |
| KLK4 | VGLL2 | 0.664193 | 4 | 0 | 4 |
| KLK4 | TNR | 0.663029 | 5 | 0 | 5 |
| KLK4 | CEACAM21 | 0.661627 | 3 | 0 | 3 |
| KLK4 | SLC35A4 | 0.65977 | 3 | 0 | 3 |
| KLK4 | CBX8 | 0.659399 | 5 | 0 | 5 |
| KLK4 | LINC01343 | 0.656071 | 5 | 0 | 4 |
For details and further investigation, click here
