| Full name: chromobox 8 | Alias Symbol: RC1|HPC3|PC3 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 57332 | HGNC ID: HGNC:15962 | Ensembl Gene: ENSG00000141570 | OMIM ID: 617354 |
| Drug and gene relationship at DGIdb | |||
Expression of CBX8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBX8 | 57332 | 219755_at | 0.1685 | 0.6235 | |
| GSE20347 | CBX8 | 57332 | 219755_at | 0.0813 | 0.2947 | |
| GSE23400 | CBX8 | 57332 | 219755_at | -0.1410 | 0.0001 | |
| GSE26886 | CBX8 | 57332 | 219755_at | -0.1883 | 0.0744 | |
| GSE29001 | CBX8 | 57332 | 219755_at | -0.0984 | 0.5697 | |
| GSE38129 | CBX8 | 57332 | 219755_at | 0.1141 | 0.2903 | |
| GSE45670 | CBX8 | 57332 | 219755_at | 0.0241 | 0.8595 | |
| GSE53622 | CBX8 | 57332 | 32231 | 0.6513 | 0.0000 | |
| GSE53624 | CBX8 | 57332 | 32231 | 0.6592 | 0.0000 | |
| GSE63941 | CBX8 | 57332 | 219755_at | 0.5653 | 0.0243 | |
| GSE77861 | CBX8 | 57332 | 219755_at | -0.1194 | 0.3162 | |
| GSE97050 | CBX8 | 57332 | A_23_P55421 | 0.2190 | 0.4148 | |
| SRP007169 | CBX8 | 57332 | RNAseq | 0.5721 | 0.2844 | |
| SRP064894 | CBX8 | 57332 | RNAseq | 1.4306 | 0.0000 | |
| SRP133303 | CBX8 | 57332 | RNAseq | 1.0669 | 0.0000 | |
| SRP159526 | CBX8 | 57332 | RNAseq | 1.6672 | 0.0003 | |
| SRP193095 | CBX8 | 57332 | RNAseq | 0.8642 | 0.0000 | |
| SRP219564 | CBX8 | 57332 | RNAseq | 1.7211 | 0.0003 | |
| TCGA | CBX8 | 57332 | RNAseq | 0.5182 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by CBX8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBX8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBX8 | 57332 | 4 | 3 | 23 | |
| GSE20123 | CBX8 | 57332 | 4 | 3 | 23 | |
| GSE43470 | CBX8 | 57332 | 3 | 5 | 35 | |
| GSE46452 | CBX8 | 57332 | 34 | 0 | 25 | |
| GSE47630 | CBX8 | 57332 | 9 | 1 | 30 | |
| GSE54993 | CBX8 | 57332 | 2 | 5 | 63 | |
| GSE54994 | CBX8 | 57332 | 10 | 5 | 38 | |
| GSE60625 | CBX8 | 57332 | 6 | 0 | 5 | |
| GSE74703 | CBX8 | 57332 | 3 | 3 | 30 | |
| GSE74704 | CBX8 | 57332 | 4 | 3 | 13 | |
| TCGA | CBX8 | 57332 | 29 | 9 | 58 |
Total number of gains: 108; Total number of losses: 37; Total Number of normals: 343.
Somatic mutations of CBX8:
Generating mutation plots.
Highly correlated genes for CBX8:
Showing top 20/648 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBX8 | PSMB11 | 0.753737 | 3 | 0 | 3 |
| CBX8 | MS4A18 | 0.745972 | 3 | 0 | 3 |
| CBX8 | CDK5R2 | 0.731742 | 4 | 0 | 4 |
| CBX8 | OPN4 | 0.730525 | 3 | 0 | 3 |
| CBX8 | TMEM102 | 0.728412 | 4 | 0 | 4 |
| CBX8 | SHISA8 | 0.728323 | 3 | 0 | 3 |
| CBX8 | RAB44 | 0.721095 | 3 | 0 | 3 |
| CBX8 | GPRIN1 | 0.720961 | 3 | 0 | 3 |
| CBX8 | RIMS4 | 0.716514 | 3 | 0 | 3 |
| CBX8 | SMPD4 | 0.714037 | 3 | 0 | 3 |
| CBX8 | OR7D4 | 0.711672 | 3 | 0 | 3 |
| CBX8 | IFITM5 | 0.710762 | 3 | 0 | 3 |
| CBX8 | RASSF7 | 0.70708 | 7 | 0 | 7 |
| CBX8 | OR2G2 | 0.703773 | 3 | 0 | 3 |
| CBX8 | TSPAN11 | 0.701076 | 3 | 0 | 3 |
| CBX8 | NPM2 | 0.6993 | 4 | 0 | 4 |
| CBX8 | CELA3B | 0.699208 | 4 | 0 | 3 |
| CBX8 | C12orf54 | 0.695149 | 3 | 0 | 3 |
| CBX8 | CORO2A | 0.690838 | 4 | 0 | 3 |
| CBX8 | ZSWIM3 | 0.68751 | 5 | 0 | 4 |
For details and further investigation, click here
