| Full name: tenascin R | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q25.1 | ||
| Entrez ID: 7143 | HGNC ID: HGNC:11953 | Ensembl Gene: ENSG00000116147 | OMIM ID: 601995 |
| Drug and gene relationship at DGIdb | |||
TNR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of TNR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNR | 7143 | 1564897_at | -0.3302 | 0.3441 | |
| GSE20347 | TNR | 7143 | 213841_at | 0.0329 | 0.6951 | |
| GSE23400 | TNR | 7143 | 206990_at | -0.0695 | 0.0399 | |
| GSE26886 | TNR | 7143 | 1564897_at | -0.6081 | 0.0004 | |
| GSE29001 | TNR | 7143 | 213841_at | 0.0074 | 0.9682 | |
| GSE38129 | TNR | 7143 | 213841_at | -0.1233 | 0.1862 | |
| GSE45670 | TNR | 7143 | 1564897_at | 0.0533 | 0.7139 | |
| GSE53622 | TNR | 7143 | 24338 | -0.1866 | 0.0001 | |
| GSE53624 | TNR | 7143 | 24338 | -0.4111 | 0.0000 | |
| GSE63941 | TNR | 7143 | 1564897_at | -0.0900 | 0.5424 | |
| GSE77861 | TNR | 7143 | 1564897_at | -0.3163 | 0.0093 | |
| GSE97050 | TNR | 7143 | A_23_P45864 | -0.0746 | 0.7433 | |
| SRP133303 | TNR | 7143 | RNAseq | 0.1256 | 0.4818 | |
| SRP193095 | TNR | 7143 | RNAseq | 0.2789 | 0.1451 | |
| SRP219564 | TNR | 7143 | RNAseq | -0.0304 | 0.9570 | |
| TCGA | TNR | 7143 | RNAseq | -1.4761 | 0.1513 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TNR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNR | 7143 | 11 | 0 | 19 | |
| GSE20123 | TNR | 7143 | 11 | 0 | 19 | |
| GSE43470 | TNR | 7143 | 7 | 2 | 34 | |
| GSE46452 | TNR | 7143 | 3 | 1 | 55 | |
| GSE47630 | TNR | 7143 | 14 | 0 | 26 | |
| GSE54993 | TNR | 7143 | 0 | 6 | 64 | |
| GSE54994 | TNR | 7143 | 15 | 0 | 38 | |
| GSE60625 | TNR | 7143 | 0 | 0 | 11 | |
| GSE74703 | TNR | 7143 | 7 | 2 | 27 | |
| GSE74704 | TNR | 7143 | 5 | 0 | 15 | |
| TCGA | TNR | 7143 | 40 | 3 | 53 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of TNR:
Generating mutation plots.
Highly correlated genes for TNR:
Showing top 20/1047 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNR | GDF7 | 0.771971 | 3 | 0 | 3 |
| TNR | TDGF1 | 0.768926 | 3 | 0 | 3 |
| TNR | ZBTB45 | 0.75064 | 3 | 0 | 3 |
| TNR | INSC | 0.750104 | 3 | 0 | 3 |
| TNR | CST11 | 0.742353 | 4 | 0 | 4 |
| TNR | POLM | 0.741849 | 5 | 0 | 5 |
| TNR | SH2D1B | 0.735785 | 3 | 0 | 3 |
| TNR | WAS | 0.732504 | 5 | 0 | 5 |
| TNR | NXPE4 | 0.730471 | 5 | 0 | 5 |
| TNR | KCNT1 | 0.729319 | 4 | 0 | 4 |
| TNR | KRTAP6-1 | 0.72823 | 3 | 0 | 3 |
| TNR | PABPN1L | 0.721902 | 3 | 0 | 3 |
| TNR | NXPH3 | 0.720914 | 5 | 0 | 4 |
| TNR | ERCC5 | 0.720323 | 3 | 0 | 3 |
| TNR | TPRX1 | 0.719982 | 3 | 0 | 3 |
| TNR | CXCL17 | 0.71539 | 4 | 0 | 4 |
| TNR | NICN1 | 0.71412 | 3 | 0 | 3 |
| TNR | ZNF497 | 0.714033 | 3 | 0 | 3 |
| TNR | BSX | 0.711023 | 3 | 0 | 3 |
| TNR | ACSBG2 | 0.70723 | 5 | 0 | 5 |
For details and further investigation, click here
