| Full name: defensin alpha 5 | Alias Symbol: HD-5 | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 1670 | HGNC ID: HGNC:2764 | Ensembl Gene: ENSG00000164816 | OMIM ID: 600472 |
| Drug and gene relationship at DGIdb | |||
Expression of DEFA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFA5 | 1670 | 207529_at | -0.2854 | 0.2363 | |
| GSE20347 | DEFA5 | 1670 | 207529_at | -0.1202 | 0.1791 | |
| GSE23400 | DEFA5 | 1670 | 207529_at | -0.2399 | 0.0000 | |
| GSE26886 | DEFA5 | 1670 | 207529_at | -0.2726 | 0.0142 | |
| GSE29001 | DEFA5 | 1670 | 207529_at | -0.3555 | 0.0090 | |
| GSE38129 | DEFA5 | 1670 | 207529_at | -0.1977 | 0.0107 | |
| GSE45670 | DEFA5 | 1670 | 207529_at | 0.0440 | 0.7927 | |
| GSE63941 | DEFA5 | 1670 | 207529_at | 0.0265 | 0.8972 | |
| GSE77861 | DEFA5 | 1670 | 207529_at | -0.3712 | 0.0099 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFA5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DEFA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFA5 | 1670 | 4 | 11 | 15 | |
| GSE20123 | DEFA5 | 1670 | 4 | 11 | 15 | |
| GSE43470 | DEFA5 | 1670 | 4 | 10 | 29 | |
| GSE46452 | DEFA5 | 1670 | 12 | 14 | 33 | |
| GSE47630 | DEFA5 | 1670 | 8 | 9 | 23 | |
| GSE54993 | DEFA5 | 1670 | 3 | 14 | 53 | |
| GSE54994 | DEFA5 | 1670 | 10 | 19 | 24 | |
| GSE60625 | DEFA5 | 1670 | 3 | 0 | 8 | |
| GSE74703 | DEFA5 | 1670 | 4 | 8 | 24 | |
| GSE74704 | DEFA5 | 1670 | 3 | 7 | 10 | |
| TCGA | DEFA5 | 1670 | 13 | 40 | 43 |
Total number of gains: 68; Total number of losses: 143; Total Number of normals: 277.
Somatic mutations of DEFA5:
Generating mutation plots.
Highly correlated genes for DEFA5:
Showing top 20/882 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFA5 | KLK4 | 0.696083 | 4 | 0 | 3 |
| DEFA5 | OPTN | 0.689142 | 3 | 0 | 3 |
| DEFA5 | ST3GAL3 | 0.687842 | 3 | 0 | 3 |
| DEFA5 | FUT9 | 0.68141 | 4 | 0 | 4 |
| DEFA5 | APBB1IP | 0.678726 | 3 | 0 | 3 |
| DEFA5 | OAZ3 | 0.667854 | 3 | 0 | 3 |
| DEFA5 | MCHR1 | 0.660572 | 4 | 0 | 4 |
| DEFA5 | OR2H2 | 0.656862 | 4 | 0 | 4 |
| DEFA5 | ZC4H2 | 0.656322 | 6 | 0 | 5 |
| DEFA5 | ZFAND2B | 0.653971 | 3 | 0 | 3 |
| DEFA5 | LINC01366 | 0.653804 | 3 | 0 | 3 |
| DEFA5 | PHF7 | 0.65332 | 7 | 0 | 6 |
| DEFA5 | SAMD5 | 0.651789 | 3 | 0 | 3 |
| DEFA5 | ZBTB7A | 0.651235 | 4 | 0 | 3 |
| DEFA5 | CAMK1G | 0.650808 | 5 | 0 | 5 |
| DEFA5 | MVK | 0.650603 | 8 | 0 | 7 |
| DEFA5 | GNRH2 | 0.649505 | 4 | 0 | 4 |
| DEFA5 | ASIC4 | 0.644006 | 4 | 0 | 4 |
| DEFA5 | LINC00557 | 0.643451 | 4 | 0 | 4 |
| DEFA5 | CYP3A43 | 0.64321 | 6 | 0 | 6 |
For details and further investigation, click here
