Full name: mitogen-activated protein kinase 3	Alias Symbol: ERK1|p44mapk|p44erk1
Type: protein-coding gene	Cytoband: 16p11.2
Entrez ID: 5595	HGNC ID: HGNC:6877	Ensembl Gene: ENSG00000102882	OMIM ID: 601795
Drug and gene relationship at DGIdb

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MAPK3 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04012	ErbB signaling pathway	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04068	FoxO signaling pathway	View
hsa04071	Sphingolipid signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04150	mTOR signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04210	Apoptosis	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04270	Vascular smooth muscle contraction	View
hsa04360	Axon guidance	View
hsa04370	VEGF signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04510	Focal adhesion	View
hsa04520	Adherens junction	View
hsa04540	Gap junction	View
hsa04550	Signaling pathways regulating pluripotency of stem cells	View
hsa04611	Platelet activation	View
hsa04620	Toll-like receptor signaling pathway	View
hsa04621	NOD-like receptor signaling pathway	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04664	Fc epsilon RI signaling pathway	View
hsa04666	Fc gamma R-mediated phagocytosis	View
hsa04668	TNF signaling pathway	View
hsa04713	Circadian entrainment	View
hsa04720	Long-term potentiation	View
hsa04722	Neurotrophin signaling pathway	View
hsa04723	Retrograde endocannabinoid signaling	View
hsa04724	Glutamatergic synapse	View
hsa04725	Cholinergic synapse	View
hsa04726	Serotonergic synapse	View
hsa04730	Long-term depression	View
hsa04810	Regulation of actin cytoskeleton	View
hsa04910	Insulin signaling pathway	View
hsa04912	GnRH signaling pathway	View
hsa04914	Progesterone-mediated oocyte maturation	View
hsa04915	Estrogen signaling pathway	View
hsa04916	Melanogenesis	View
hsa04917	Prolactin signaling pathway	View
hsa04919	Thyroid hormone signaling pathway	View
hsa04921	Oxytocin signaling pathway	View
hsa04930	Type II diabetes mellitus	View
hsa04933	AGE-RAGE signaling pathway in diabetic complications	View
hsa05020	Prion diseases	View
hsa05034	Alcoholism	View
hsa05131	Shigellosis	View
hsa05132	Salmonella infection	View
hsa05133	Pertussis	View
hsa05140	Leishmaniasis	View
hsa05142	Chagas disease (American trypanosomiasis)	View
hsa05145	Toxoplasmosis	View
hsa05152	Tuberculosis	View
hsa05160	Hepatitis C	View
hsa05161	Hepatitis B	View
hsa05164	Influenza A	View
hsa05200	Pathways in cancer	View
hsa05205	Proteoglycans in cancer	View
hsa05210	Colorectal cancer	View
hsa05211	Renal cell carcinoma	View
hsa05212	Pancreatic cancer	View
hsa05213	Endometrial cancer	View
hsa05214	Glioma	View
hsa05215	Prostate cancer	View
hsa05216	Thyroid cancer	View
hsa05218	Melanoma	View
hsa05219	Bladder cancer	View
hsa05220	Chronic myeloid leukemia	View
hsa05221	Acute myeloid leukemia	View
hsa05223	Non-small cell lung cancer	View
hsa05231	Choline metabolism in cancer	View

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Expression of MAPK3:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	MAPK3	5595	212046_x_at	-0.6841	0.0824	Show
GSE20347	MAPK3	5595	212046_x_at	-0.7870	0.0000	Show
GSE23400	MAPK3	5595	212046_x_at	-0.6625	0.0000	Show
GSE26886	MAPK3	5595	212046_x_at	-1.1034	0.0000	Show
GSE29001	MAPK3	5595	212046_x_at	-0.9499	0.0000	Show
GSE38129	MAPK3	5595	212046_x_at	-0.7509	0.0000	Show
GSE45670	MAPK3	5595	212046_x_at	-0.5068	0.0015	Show
GSE53622	MAPK3	5595	27711	-1.3505	0.0000	Show
GSE53624	MAPK3	5595	27711	-1.3777	0.0000	Show
GSE63941	MAPK3	5595	212046_x_at	-0.1411	0.5454	Show
GSE77861	MAPK3	5595	212046_x_at	-0.6228	0.0064	Show
GSE97050	MAPK3	5595	A_23_P37910	-0.5387	0.1398	Show
SRP007169	MAPK3	5595	RNAseq	-3.3518	0.0000	Show
SRP008496	MAPK3	5595	RNAseq	-3.0500	0.0000	Show
SRP064894	MAPK3	5595	RNAseq	-1.7250	0.0000	Show
SRP133303	MAPK3	5595	RNAseq	-1.5299	0.0000	Show
SRP159526	MAPK3	5595	RNAseq	-1.6113	0.0000	Show
SRP193095	MAPK3	5595	RNAseq	-1.7313	0.0000	Show
SRP219564	MAPK3	5595	RNAseq	-1.6466	0.0011	Show
TCGA	MAPK3	5595	RNAseq	-0.1598	0.0064	Show

Upregulated datasets: 0; Downregulated datasets: 10.  Download Data

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Survival by MAPK3 expression:

 

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Copy number change of MAPK3:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	MAPK3	5595	5	5	20	Show
GSE20123	MAPK3	5595	5	4	21	Show
GSE43470	MAPK3	5595	3	3	37	Show
GSE46452	MAPK3	5595	38	1	20	Show
GSE47630	MAPK3	5595	11	7	22	Show
GSE54993	MAPK3	5595	2	5	63	Show
GSE54994	MAPK3	5595	5	9	39	Show
GSE60625	MAPK3	5595	4	0	7	Show
GSE74703	MAPK3	5595	3	2	31	Show
GSE74704	MAPK3	5595	3	2	15	Show
TCGA	MAPK3	5595	20	11	65	Show

Total number of gains: 99; Total number of losses: 49; Total Number of normals: 340.  Download Data

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Somatic mutations of MAPK3:

 

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Highly correlated genes for MAPK3:

 

Showing top 20/1883 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
MAPK3	ENDOU	0.873513	11	0	11
MAPK3	SNORA68	0.868812	4	0	4
MAPK3	SCNN1B	0.865745	11	0	11
MAPK3	CYSRT1	0.861811	6	0	6
MAPK3	SLC35C1	0.861645	10	0	10
MAPK3	SASH1	0.859338	11	0	11
MAPK3	FAM3D	0.858305	7	0	7
MAPK3	TRIP10	0.856929	11	0	11
MAPK3	PPL	0.856027	11	0	11
MAPK3	SH3BGRL2	0.851351	7	0	7
MAPK3	GYS2	0.850111	10	0	10
MAPK3	HCG22	0.845621	6	0	6
MAPK3	SFTA2	0.844216	4	0	4
MAPK3	EPGN	0.842459	3	0	3
MAPK3	CRISP3	0.841201	11	0	11
MAPK3	ASPG	0.840838	6	0	6
MAPK3	SMIM5	0.839399	6	0	6
MAPK3	SLURP1	0.838274	11	0	11
MAPK3	VSIG10L	0.836303	7	0	7
MAPK3	ATG9B	0.832555	7	0	7

For details and further investigation, click here